SUPERFAMILY 1.75 HMM library and genome assignments server

Myosin rod fragments superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Myosin rod fragments [ 90257]
Families:   Myosin rod fragments [ 90258] (2)


Superfamily statistics
Genomes (678) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,016 13,032 6
Proteins 4,000 6,222 4


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000000000007347 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000000002093 Least Informative Direct
Biological Process (BP) developmental process 0.000000000004126 Least Informative Direct
Biological Process (BP) localization 0.000003598 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00001327 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.03936 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.09986 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2086 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.116 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.3999 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6166 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.004294 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.000000000000001938 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000000000001938 Moderately Informative Direct
Biological Process (BP) system process 0.00000000001214 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000001439 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000006871 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000006713 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000001624 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000001661 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000005005 Moderately Informative Direct
Biological Process (BP) tissue development 0.000005988 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000008851 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0006379 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.001117 Moderately Informative Inherited
Biological Process (BP) organ development 0.1248 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05714 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001417 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1638 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5778 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.08054 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.007153 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1145 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2078 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9249 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.04337 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.003223 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002834 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) muscle tissue development 0 Informative Direct
Biological Process (BP) organelle assembly 0.000000000000003755 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000000000000003755 Informative Direct
Biological Process (BP) locomotion 0.000000000000003755 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0000000000008224 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000000000192 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000000000002574 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000000000005886 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000000001482 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000000001744 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0000000008303 Informative Direct
Biological Process (BP) localization of cell 0.000000005585 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000008115 Informative Direct
Biological Process (BP) cell cycle process 0.00000004724 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000009292 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0000001181 Informative Direct
Biological Process (BP) cell projection organization 0.0000002769 Informative Direct
Biological Process (BP) blood circulation 0.000002252 Informative Direct
Biological Process (BP) response to wounding 0.000004919 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0000529 Informative Direct
Biological Process (BP) organelle localization 0.00005328 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00009915 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0001193 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0001834 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0003133 Informative Direct
Biological Process (BP) regulation of system process 0.0003393 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0004807 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0004905 Informative Direct
Biological Process (BP) generation of neurons 0.0005415 Informative Direct
Biological Process (BP) regulation of growth 0.08461 Informative Inherited
Biological Process (BP) sensory organ development 0.6829 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1025 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.004286 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1022 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.0206 Informative Inherited
Biological Process (BP) microtubule-based process 0.03757 Informative Inherited
Biological Process (BP) leukocyte activation 0.01232 Informative Inherited
Biological Process (BP) proteolysis 0.1633 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.6188 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.7569 Informative Inherited
Biological Process (BP) central nervous system development 0.5851 Informative Inherited
Biological Process (BP) biological adhesion 0.001947 Informative Inherited
Biological Process (BP) secretion by cell 0.002912 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.3838 Informative Inherited
Biological Process (BP) cardiocyte differentiation 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.000000000000001938 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00000000000007678 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00000000000009263 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0000000000001705 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0000000000001797 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.0000000000002358 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.0000000000002643 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.0000000001426 Highly Informative Direct
Biological Process (BP) cell division 0.000000000239 Highly Informative Direct
Biological Process (BP) wound healing 0.0000000005325 Highly Informative Direct
Biological Process (BP) muscle organ development 0.000000003748 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000002544 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.000004358 Highly Informative Direct
Biological Process (BP) exocytosis 0.0002902 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0003509 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0004353 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0005279 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000716 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0007584 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.1031 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.001074 Highly Informative Inherited
Biological Process (BP) muscle fiber development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1605 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.04052 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9944 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.003159 Highly Informative Inherited
Biological Process (BP) spindle organization 0.02665 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00000000008512 Least Informative Direct
Molecular Function (MF) binding 0.00000007312 Least Informative Direct
Molecular Function (MF) structural molecule activity 0.00000007184 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001136 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000007151 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000001606 Informative Direct
Molecular Function (MF) nucleotide binding 0.00005613 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0006501 Informative Direct
Molecular Function (MF) protein dimerization activity 0.1642 Informative Inherited
Molecular Function (MF) actin filament binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000001572 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0008442 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000000000001758 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0002302 Least Informative Direct
Cellular Component (CC) membrane 0.00534 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000000000003095 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.005918 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.1224 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell leading edge 0.0000008621 Informative Direct
Cellular Component (CC) cell junction 0.00000506 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.7267 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.9537 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell division site part 0.000000000002548 Highly Informative Direct
Cellular Component (CC) adherens junction 0.000001136 Highly Informative Direct
Cellular Component (CC) growth cone 0.000001911 Highly Informative Direct
Cellular Component (CC) spindle 0.0002536 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.1892 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.3869 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscular disease0.01412Moderately InformativeInherited
Disease Ontology (DO)heart disease0.035InformativeInherited
Disease Ontology (DO)dilated cardiomyopathy0.0006777Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3744Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.03571Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.1199Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.3815Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.003165InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.01452InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium0.07578InformativeInherited
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.00001127Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the coronary arteries0.0002594Highly InformativeDirect
Phenotypic Abnormality (PA)Lipoatrophy0.0002594Highly InformativeDirect
Phenotypic Abnormality (PA)Dilated cardiomyopathy0.0003109Highly InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0.0007292Highly InformativeDirect
Phenotypic Abnormality (PA)Arterial stenosis1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0804Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.008299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7629Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0002368InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.2041InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.04875Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.07034Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0004565Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0007731Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.00883Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.009077Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.000005188InformativeDirect
Worm Phenotype (WP)drug resistant0.000388InformativeDirect
Worm Phenotype (WP)activity level variant0.004914InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective0.000006034Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.00008565Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00000191Moderately InformativeDirect
Biological processDifferentiation0.0009526Moderately InformativeDirect
Biological processCell adhesion0.00000005749InformativeDirect
Biological processCell shape0.0000007119InformativeDirect
Cellular componentCytoplasm0.00000000002853Least InformativeDirect
Cellular componentCell projection0.000000000009036Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000003216Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000368Moderately InformativeDirect
Cellular componentMicrotubule0.00005123InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationAcetylation0.00065Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000000007666Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000002363Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin rod fragments domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Myosin rod fragments superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]