SUPERFAMILY 1.75 HMM library and genome assignments server


Troponin coil-coiled subunits superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Troponin coil-coiled subunits [ 90250] (2)
Families:   Troponin T [ 90251]
  Troponin I [ 90254]


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,254 1,563 7
Proteins 1,243 1,546 7


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.62340.00983Least InformativeInherited
Biological Process (BP)developmental process0.0076960.0000000000003724Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0038460.00000000000003095Least InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.000071380.000000000005416Moderately InformativeDirect
Biological Process (BP)tissue development0.004470.00001001Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.005370Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.0044430.00000006446Moderately InformativeInherited
Biological Process (BP)organ development0.081540.007453Moderately InformativeInherited
Biological Process (BP)muscle structure development0.0000000035070InformativeDirect
Biological Process (BP)muscle tissue development0.000000021460InformativeDirect
Biological Process (BP)cardiovascular system development0.0000023780InformativeDirect
Biological Process (BP)tissue morphogenesis0.000033620.000000000001159InformativeDirect
Biological Process (BP)regulation of system process0.000036880InformativeDirect
Biological Process (BP)actin filament-based process0.000070040InformativeDirect
Biological Process (BP)organ morphogenesis0.00021040.00000001379InformativeDirect
Biological Process (BP)cardiac muscle tissue development0.00000000048370.00000000000002434Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.0000000012890.00000000000003095Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction0.000000050210Highly InformativeDirect
Biological Process (BP)muscle organ development0.0000061480Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.42640.000000000000003132Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.17080.000001874Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.031530Least InformativeInherited
Cellular Component (CC)protein complex0.061490.00000000000001492Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0018990.00000006093Moderately InformativeInherited
Cellular Component (CC)contractile fiber part0.0000041540InformativeDirect
Cellular Component (CC)actin cytoskeleton0.000059880InformativeDirect
Cellular Component (CC)myofilament0.000000036510Highly InformativeDirect
Cellular Component (CC)sarcomere0.0000017760Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000000000003095 Least Informative Direct
Biological Process (BP) developmental process 0.0000000000003724 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00983 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7702 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.005925 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.000000000005416 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.00000006446 Moderately Informative Direct
Biological Process (BP) tissue development 0.00001001 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.000000001258 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000003489 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000001492 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000001598 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0005737 Moderately Informative Direct
Biological Process (BP) organelle organization 0.001898 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.03999 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.004929 Moderately Informative Inherited
Biological Process (BP) organ development 0.007453 Moderately Informative Inherited
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) muscle tissue development 0 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000000000001159 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) organ morphogenesis 0.00000001379 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000000007765 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0000000000001259 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0000000000003679 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000000000003059 Informative Direct
Biological Process (BP) blood circulation 0.0000000004902 Informative Direct
Biological Process (BP) response to inorganic substance 0.000000002597 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0000001368 Informative Direct
Biological Process (BP) cellular component movement 0.0000006201 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00004463 Informative Direct
Biological Process (BP) metal ion homeostasis 0.00007534 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.00008616 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001171 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.001279 Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.00000000000002434 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.00000000000003095 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.00000000000007131 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000000000002733 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0000000003886 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00000303 Highly Informative Direct
Molecular Function (MF) binding 0.005389 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.00001367 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000000001492 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000001874 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000000003132 Least Informative Direct
Cellular Component (CC) cytoskeleton 0.00000006093 Moderately Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) myofilament 0 Highly Informative Direct
Cellular Component (CC) sarcomere 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008466Moderately InformativeInherited
Disease Ontology (DO)coronary artery disease0.0003681InformativeDirect
Disease Ontology (DO)cardiomyopathy0.0395InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.314Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal joint morphology0.0597Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1164InformativeInherited
Phenotypic Abnormality (PA)Limb joint contracture0.001875Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001488Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0004144Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0007785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.02022Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.07927Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.00000006022InformativeDirect
Worm Phenotype (WP)copulation variant0.00001657InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.000017InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.00009908InformativeDirect
Worm Phenotype (WP)neuron development variant0.0002413InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004504InformativeDirect
Worm Phenotype (WP)body length variant0.001979InformativeInherited
Worm Phenotype (WP)body width variant0.002389InformativeInherited
Worm Phenotype (WP)egg laying variant0.2117InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)axon development variant0.0000004442Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.000008179Highly InformativeDirect
Worm Phenotype (WP)body vacuole0.00003634Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0008842Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.1134Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.1278Highly InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Molecular functionMetal-binding0.0001374Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000000002823Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Troponin coil-coiled subunits domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Troponin coil-coiled subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]