SUPERFAMILY 1.75 HMM library and genome assignments server

Troponin coil-coiled subunits superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Troponin coil-coiled subunits [ 90250] (2)
Families:   Troponin T [ 90251]
  Troponin I [ 90254]


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,326 1,563 7
Proteins 1,314 1,546 7


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.93510.4456Least InformativeInherited
Biological Process (BP)developmental process0.0087520.0000000000009747Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0037440.0000000000000226Least InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.000086590.00000000000558Moderately InformativeDirect
Biological Process (BP)tissue development0.0038560.00001096Moderately InformativeInherited
Biological Process (BP)organ development0.079260.006083Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0048990Moderately InformativeInherited
Biological Process (BP)muscle structure development0.0000000030180InformativeDirect
Biological Process (BP)cardiovascular system development0.0000026710InformativeDirect
Biological Process (BP)regulation of system process0.000008260InformativeDirect
Biological Process (BP)tissue morphogenesis0.000014880.0000000000000406InformativeDirect
Biological Process (BP)actin filament-based process0.000077530InformativeDirect
Biological Process (BP)organ morphogenesis0.00010370.0000000004771InformativeDirect
Biological Process (BP)cardiac muscle tissue development0.00000000076290.000000000001091Highly InformativeDirect
Biological Process (BP)heart morphogenesis0.0000000017730.00000000000003411Highly InformativeDirect
Biological Process (BP)muscle organ development0.0000013980Highly InformativeDirect
Biological Process (BP)regulation of muscle system process0.000000086140.2051Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.44750.00000000000001325Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.039260Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.180.000001188Least InformativeInherited
Cellular Component (CC)protein complex0.065290.00000000000002857Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0021020.00000006635Moderately InformativeInherited
Cellular Component (CC)contractile fiber part0.0000042990InformativeDirect
Cellular Component (CC)actin cytoskeleton0.000062880InformativeDirect
Cellular Component (CC)sarcomere0.0000018610Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000000000000226 Least Informative Direct
Biological Process (BP) developmental process 0.0000000000009747 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.4456 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01146 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8455 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.00000000000558 Moderately Informative Direct
Biological Process (BP) tissue development 0.00001096 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.000000003141 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000002366 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0000002904 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000342 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000001631 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00005641 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0009536 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.8965 Moderately Informative Inherited
Biological Process (BP) organ development 0.006083 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02096 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.04159 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001228 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.007476 Moderately Informative Inherited
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000000000000406 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000000004771 Informative Direct
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000000001499 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0000000000002685 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0000000000004141 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00000000001776 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.00000000004244 Informative Direct
Biological Process (BP) blood circulation 0.0000000006524 Informative Direct
Biological Process (BP) cellular component movement 0.000000002742 Informative Direct
Biological Process (BP) response to inorganic substance 0.000000004327 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000103 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000003461 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001324 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001455 Informative Direct
Biological Process (BP) cation homeostasis 0.0002774 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.04195 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.08863 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.001262 Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.000000000001091 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.00000000000003411 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.00000000000006308 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000000000000373 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0000000004056 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.000003556 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.2051 Highly Informative Inherited
Molecular Function (MF) binding 0.01111 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0000164 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000000002857 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000001188 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000001325 Least Informative Direct
Cellular Component (CC) cytoskeleton 0.00000006635 Moderately Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) sarcomere 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008733Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.03457Moderately InformativeInherited
Disease Ontology (DO)heart disease0.00003257InformativeDirect
Disease Ontology (DO)coronary artery disease0.0003737InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3107Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal joint morphology0.05833Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1146InformativeInherited
Phenotypic Abnormality (PA)Limb joint contracture0.001783Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001488Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0004144Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0007785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.02022Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.07927Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.00000006022InformativeDirect
Worm Phenotype (WP)copulation variant0.00001657InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.000017InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.00009908InformativeDirect
Worm Phenotype (WP)neuron development variant0.0002413InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004504InformativeDirect
Worm Phenotype (WP)body length variant0.001979InformativeInherited
Worm Phenotype (WP)body width variant0.002389InformativeInherited
Worm Phenotype (WP)egg laying variant0.2117InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)axon development variant0.0000004442Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.000008179Highly InformativeDirect
Worm Phenotype (WP)body vacuole0.00003634Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0008842Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.1134Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.1278Highly InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Molecular functionMetal-binding0.000163Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000000002839Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Troponin coil-coiled subunits domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Troponin coil-coiled subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]