Troponin coil-coiled subunits superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Coiled coil proteins [ 57942] (7)
Fold:	Parallel coiled-coil [ 57943] (34)
Superfamily:	Troponin coil-coiled subunits [ 90250] (2)
Families:	Troponin T [ 90251]
	Troponin I [ 90254]

Superfamily statistics

	Genomes (126)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	1,228	1,286	7
Proteins	1,218	1,275	7

Functional annotation

General category	Processes_IC
Detailed category	Cell motility

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism cellular process	0.7228	0.0183	Least Informative	Inherited
Biological Process (BP)	developmental process	0.01198	3.756e-11	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	0.006717	4.342e-12	Least Informative	Inherited
Biological Process (BP)	anatomical structure morphogenesis	0.0001304	3.96e-11	Moderately Informative	Direct
Biological Process (BP)	tissue development	0.00337	3.53e-05	Moderately Informative	Inherited
Biological Process (BP)	regulation of multicellular organismal process	0.006105	0	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	0.004172	1.57e-07	Moderately Informative	Inherited
Biological Process (BP)	organ development	0.07374	0.01193	Moderately Informative	Inherited
Biological Process (BP)	muscle structure development	7.154e-09	0	Informative	Direct
Biological Process (BP)	muscle tissue development	3.512e-08	0	Informative	Direct
Biological Process (BP)	cardiovascular system development	3.612e-06	0	Informative	Direct
Biological Process (BP)	tissue morphogenesis	2.489e-05	5.115e-11	Informative	Direct
Biological Process (BP)	regulation of system process	3.305e-05	0	Informative	Direct
Biological Process (BP)	actin filament-based process	0.0001076	0	Informative	Direct
Biological Process (BP)	organ morphogenesis	0.0002444	2.023e-07	Informative	Direct
Biological Process (BP)	cardiac muscle tissue development	1.022e-09	7.878e-13	Highly Informative	Direct
Biological Process (BP)	heart morphogenesis	1.43e-09	1.856e-13	Highly Informative	Direct
Biological Process (BP)	regulation of muscle contraction	1.126e-07	0	Highly Informative	Direct
Biological Process (BP)	muscle organ development	8.779e-06	0	Highly Informative	Direct
Molecular Function (MF)	binding	0.8065	0.006131	Least Informative	Inherited
Molecular Function (MF)	protein binding	0.3528	0.000258	Moderately Informative	Inherited
Molecular Function (MF)	cytoskeletal protein binding	6.728e-05	0	Informative	Direct
Cellular Component (CC)	cytoplasmic part	0.5802	3.61e-12	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	0.08617	7.93e-07	Least Informative	Inherited
Cellular Component (CC)	intracellular non-membrane-bounded organelle	0.009943	0	Least Informative	Inherited
Cellular Component (CC)	protein complex	0.01631	2.274e-13	Least Informative	Inherited
Cellular Component (CC)	cytoskeleton	0.0002886	8.994e-08	Moderately Informative	Direct
Cellular Component (CC)	contractile fiber part	1.321e-07	0	Informative	Direct
Cellular Component (CC)	actin cytoskeleton	4.092e-06	0	Informative	Direct
Cellular Component (CC)	sarcomere	4.417e-08	0	Highly Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	multicellular organismal process	4.342e-12	Least Informative	Direct
Biological Process (BP)	developmental process	3.756e-11	Least Informative	Direct
Biological Process (BP)	single-organism cellular process	0.0183	Least Informative	Inherited
Biological Process (BP)	regulation of metabolic process	0.931	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	1	Least Informative	Inherited
Biological Process (BP)	response to stimulus	0.8572	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	0.0495	Least Informative	Inherited
Biological Process (BP)	anatomical structure morphogenesis	3.96e-11	Moderately Informative	Direct
Biological Process (BP)	tissue development	3.53e-05	Moderately Informative	Direct
Biological Process (BP)	single-organism developmental process	1.57e-07	Moderately Informative	Direct
Biological Process (BP)	regulation of multicellular organismal process	0	Moderately Informative	Direct
Biological Process (BP)	system process	7.487e-14	Moderately Informative	Direct
Biological Process (BP)	cell differentiation	5.089e-06	Moderately Informative	Direct
Biological Process (BP)	regulation of molecular function	0.0002249	Moderately Informative	Direct
Biological Process (BP)	regulation of nitrogen compound metabolic process	0.001244	Moderately Informative	Inherited
Biological Process (BP)	regulation of cellular metabolic process	0.01314	Moderately Informative	Inherited
Biological Process (BP)	organelle organization	0.006302	Moderately Informative	Inherited
Biological Process (BP)	homeostatic process	0.01128	Moderately Informative	Inherited
Biological Process (BP)	organ development	0.01193	Moderately Informative	Inherited
Biological Process (BP)	muscle structure development	0	Informative	Direct
Biological Process (BP)	muscle tissue development	0	Informative	Direct
Biological Process (BP)	cardiovascular system development	0	Informative	Direct
Biological Process (BP)	tissue morphogenesis	5.115e-11	Informative	Direct
Biological Process (BP)	regulation of system process	0	Informative	Direct
Biological Process (BP)	actin filament-based process	0	Informative	Direct
Biological Process (BP)	organ morphogenesis	2.023e-07	Informative	Direct
Biological Process (BP)	muscle system process	0	Informative	Direct
Biological Process (BP)	regulation of cellular catabolic process	1.352e-13	Informative	Direct
Biological Process (BP)	regulation of hydrolase activity	1.079e-11	Informative	Direct
Biological Process (BP)	cytoskeleton organization	5.57e-11	Informative	Direct
Biological Process (BP)	cellular component movement	6.528e-09	Informative	Direct
Biological Process (BP)	response to inorganic substance	8.513e-09	Informative	Direct
Biological Process (BP)	blood circulation	2.219e-08	Informative	Direct
Biological Process (BP)	negative regulation of molecular function	1.348e-06	Informative	Direct
Biological Process (BP)	anatomical structure formation involved in morphogenesis	4.281e-06	Informative	Direct
Biological Process (BP)	metal ion homeostasis	4.333e-05	Informative	Direct
Biological Process (BP)	cellular cation homeostasis	0.0001141	Informative	Direct
Biological Process (BP)	cellular component morphogenesis	0.0003265	Informative	Direct
Biological Process (BP)	positive regulation of catalytic activity	0.01343	Informative	Inherited
Biological Process (BP)	cardiac muscle tissue development	7.878e-13	Highly Informative	Direct
Biological Process (BP)	heart morphogenesis	1.856e-13	Highly Informative	Direct
Biological Process (BP)	regulation of muscle contraction	0	Highly Informative	Direct
Biological Process (BP)	muscle organ development	0	Highly Informative	Direct
Biological Process (BP)	response to calcium ion	0	Highly Informative	Direct
Biological Process (BP)	regulation of purine nucleotide catabolic process	0	Highly Informative	Direct
Biological Process (BP)	regulation of nucleoside metabolic process	4.008e-15	Highly Informative	Direct
Biological Process (BP)	actin filament-based movement	2.944e-13	Highly Informative	Direct
Biological Process (BP)	cellular component assembly involved in morphogenesis	1.761e-10	Highly Informative	Direct
Biological Process (BP)	actomyosin structure organization	1.713e-09	Highly Informative	Direct
Biological Process (BP)	cellular calcium ion homeostasis	4.282e-06	Highly Informative	Direct
Molecular Function (MF)	binding	0.006131	Least Informative	Inherited
Molecular Function (MF)	protein binding	0.000258	Moderately Informative	Direct
Molecular Function (MF)	cytoskeletal protein binding	0	Informative	Direct
Cellular Component (CC)	intracellular non-membrane-bounded organelle	0	Least Informative	Direct
Cellular Component (CC)	protein complex	2.274e-13	Least Informative	Direct
Cellular Component (CC)	intracellular organelle part	7.93e-07	Least Informative	Direct
Cellular Component (CC)	cytoplasmic part	3.61e-12	Least Informative	Direct
Cellular Component (CC)	cytoskeleton	8.994e-08	Moderately Informative	Direct
Cellular Component (CC)	contractile fiber part	0	Informative	Direct
Cellular Component (CC)	actin cytoskeleton	0	Informative	Direct
Cellular Component (CC)	sarcomere	0	Highly Informative	Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	heart disease	9.499e-05	Moderately Informative	Direct
Disease Ontology (DO)	myocardial infarction	0.0002045	Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of muscle morphology	0	Moderately Informative	Direct

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	Least Informative	Direct
Worm Phenotype (WP)	developmental timing variant	0	Least Informative	Direct
Worm Phenotype (WP)	organism environmental stimulus response variant	0.001488	Least Informative	Inherited
Worm Phenotype (WP)	locomotion variant	0.0004144	Moderately Informative	Direct
Worm Phenotype (WP)	organism segment morphology variant	0.0007785	Moderately Informative	Direct
Worm Phenotype (WP)	organ system development variant	0.02022	Moderately Informative	Inherited
Worm Phenotype (WP)	chemical response variant	0.07927	Moderately Informative	Inherited
Worm Phenotype (WP)	nicotine response variant	6.022e-08	Informative	Direct
Worm Phenotype (WP)	copulation variant	1.657e-05	Informative	Direct
Worm Phenotype (WP)	muscle cell morphology variant	1.7e-05	Informative	Direct
Worm Phenotype (WP)	body wall muscle morphology variant	9.908e-05	Informative	Direct
Worm Phenotype (WP)	neuron development variant	0.0002413	Informative	Direct
Worm Phenotype (WP)	exploded through vulva	0.0004504	Informative	Direct
Worm Phenotype (WP)	body length variant	0.001979	Informative	Inherited
Worm Phenotype (WP)	body width variant	0.002389	Informative	Inherited
Worm Phenotype (WP)	egg laying variant	0.2117	Informative	Inherited
Worm Phenotype (WP)	male behavior variant	1	Informative	Inherited
Worm Phenotype (WP)	axon development variant	4.442e-07	Highly Informative	Direct
Worm Phenotype (WP)	egg laying defective	8.179e-06	Highly Informative	Direct
Worm Phenotype (WP)	body vacuole	3.634e-05	Highly Informative	Direct
Worm Phenotype (WP)	alimentary system morphology variant	0.0008842	Highly Informative	Direct
Worm Phenotype (WP)	post hermaphrodite contact variant	0.1134	Highly Informative	Inherited
Worm Phenotype (WP)	male mating defective	0.1278	Highly Informative	Inherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	embryo	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	portion of tissue	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	musculoskeletal system	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	embryonic structure	0	Moderately Informative	Direct
Xenopus DEvelopment stage (XDE)	embryonic stage	0	Least Informative	Direct

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Molecular function	Metal-binding	5.681e-05	Least Informative	Direct
Molecular function	Calcium	0	Moderately Informative	Direct
Molecular function	Actin-binding	0	Informative	Direct
Post-translational modification	Muscle protein	0	Highly Informative	Direct
Post-translational modification	Phosphoprotein	1.746e-09	Least Informative	Direct
Post-translational modification	Acetylation	0	Moderately Informative	Direct

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Troponin coil-coiled subunits domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Troponin coil-coiled subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Troponin coil-coiled subunits superfamily