SUPERFAMILY 1.75 HMM library and genome assignments server


Troponin coil-coiled subunits superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Troponin coil-coiled subunits [ 90250] (2)
Families:   Troponin T [ 90251]
  Troponin I [ 90254]


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,254 0 7
Proteins 1,243 0 7


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.62340.00983Least InformativeInherited
Biological Process (BP)developmental process0.0076963.724e-13Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0038463.095e-14Least InformativeInherited
Biological Process (BP)anatomical structure morphogenesis7.138e-055.416e-12Moderately InformativeDirect
Biological Process (BP)tissue development0.004471.001e-05Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.005370Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.0044436.446e-08Moderately InformativeInherited
Biological Process (BP)organ development0.081540.007453Moderately InformativeInherited
Biological Process (BP)muscle structure development3.507e-090InformativeDirect
Biological Process (BP)muscle tissue development2.146e-080InformativeDirect
Biological Process (BP)cardiovascular system development2.378e-060InformativeDirect
Biological Process (BP)tissue morphogenesis3.362e-051.159e-12InformativeDirect
Biological Process (BP)regulation of system process3.688e-050InformativeDirect
Biological Process (BP)actin filament-based process7.004e-050InformativeDirect
Biological Process (BP)organ morphogenesis0.00021041.379e-08InformativeDirect
Biological Process (BP)cardiac muscle tissue development4.837e-102.434e-14Highly InformativeDirect
Biological Process (BP)heart morphogenesis1.289e-093.095e-14Highly InformativeDirect
Biological Process (BP)regulation of muscle contraction5.021e-080Highly InformativeDirect
Biological Process (BP)muscle organ development6.148e-060Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.42643.132e-15Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.17081.874e-06Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.031530Least InformativeInherited
Cellular Component (CC)protein complex0.061491.492e-14Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0018996.093e-08Moderately InformativeInherited
Cellular Component (CC)contractile fiber part4.154e-060InformativeDirect
Cellular Component (CC)actin cytoskeleton5.988e-050InformativeDirect
Cellular Component (CC)myofilament3.651e-080Highly InformativeDirect
Cellular Component (CC)sarcomere1.776e-060Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 3.095e-14 Least Informative Direct
Biological Process (BP) developmental process 3.724e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00983 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7702 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.005925 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 5.416e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 6.446e-08 Moderately Informative Direct
Biological Process (BP) tissue development 1.001e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1.258e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 3.489e-08 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.492e-07 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.598e-07 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0005737 Moderately Informative Direct
Biological Process (BP) organelle organization 0.001898 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.03999 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.004929 Moderately Informative Inherited
Biological Process (BP) organ development 0.007453 Moderately Informative Inherited
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) muscle tissue development 0 Informative Direct
Biological Process (BP) cardiovascular system development 0 Informative Direct
Biological Process (BP) tissue morphogenesis 1.159e-12 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) organ morphogenesis 1.379e-08 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 7.765e-14 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.259e-13 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 3.679e-13 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 3.059e-12 Informative Direct
Biological Process (BP) blood circulation 4.902e-10 Informative Direct
Biological Process (BP) response to inorganic substance 2.597e-09 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 1.368e-07 Informative Direct
Biological Process (BP) cellular component movement 6.201e-07 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.463e-05 Informative Direct
Biological Process (BP) metal ion homeostasis 7.534e-05 Informative Direct
Biological Process (BP) cellular cation homeostasis 8.616e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001171 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.001279 Informative Inherited
Biological Process (BP) cardiac muscle tissue development 2.434e-14 Highly Informative Direct
Biological Process (BP) heart morphogenesis 3.095e-14 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0 Highly Informative Direct
Biological Process (BP) actin filament-based movement 7.131e-14 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 2.733e-12 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 3.886e-10 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 3.03e-06 Highly Informative Direct
Molecular Function (MF) binding 0.005389 Least Informative Inherited
Molecular Function (MF) structural molecule activity 1.367e-05 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 1.492e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1.874e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 3.132e-15 Least Informative Direct
Cellular Component (CC) cytoskeleton 6.093e-08 Moderately Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) myofilament 0 Highly Informative Direct
Cellular Component (CC) sarcomere 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008466Moderately InformativeInherited
Disease Ontology (DO)coronary artery disease0.0003681InformativeDirect
Disease Ontology (DO)cardiomyopathy0.0395InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.314Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal joint morphology0.0597Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1164InformativeInherited
Phenotypic Abnormality (PA)Limb joint contracture0.001875Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001488Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0004144Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0007785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.02022Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.07927Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant6.022e-08InformativeDirect
Worm Phenotype (WP)copulation variant1.657e-05InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant1.7e-05InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant9.908e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.0002413InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004504InformativeDirect
Worm Phenotype (WP)body length variant0.001979InformativeInherited
Worm Phenotype (WP)body width variant0.002389InformativeInherited
Worm Phenotype (WP)egg laying variant0.2117InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)axon development variant4.442e-07Highly InformativeDirect
Worm Phenotype (WP)egg laying defective8.179e-06Highly InformativeDirect
Worm Phenotype (WP)body vacuole3.634e-05Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0008842Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.1134Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.1278Highly InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Molecular functionMetal-binding0.0001374Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein2.823e-10Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Troponin coil-coiled subunits domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Troponin coil-coiled subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]