SUPERFAMILY 1.75 HMM library and genome assignments server

Glycoside hydrolase/deacetylase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   7-stranded beta/alpha barrel [ 51988] (3)
Superfamily:   Glycoside hydrolase/deacetylase [ 88713] (8)
Families:   4-alpha-glucanotransferase, N-terminal domain [ 89554]
  alpha-mannosidase [ 88714] (2)
  AmyC N-terminal domain-like [ 102189] (2)
  NodB-like polysaccharide deacetylase [ 89559] (6)
  LamB/YcsF-like [ 117449] (3)
  PA1517-like [ 141965]
  Divergent polysaccharide deacetylase [ 141968]
  YdjC-like [ 159441]


Superfamily statistics
Genomes (2,946) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,594 84,476 25
Proteins 16,519 84,350 25


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)hydrolase activity0.7060.0000000001047Least InformativeInherited
Molecular Function (MF)deacetylase activity0.0000000049960.00000000000004834Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00000000006772 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.8615 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7757 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04468 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.0251 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6387 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.4853 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.8069 Moderately Informative Inherited
Biological Process (BP) hexose metabolic process 0.00002565 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00004796 Informative Direct
Biological Process (BP) organ morphogenesis 0.3166 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3489 Informative Inherited
Biological Process (BP) single-organism behavior 0.001799 Informative Inherited
Biological Process (BP) immune effector process 0.01018 Informative Inherited
Biological Process (BP) growth 0.05865 Informative Inherited
Biological Process (BP) response to light stimulus 0.03258 Informative Inherited
Biological Process (BP) protein glycosylation 0.0001776 Highly Informative Direct
Biological Process (BP) respiratory system development 0.000008063 Highly Informative Direct
Biological Process (BP) developmental growth 0.01352 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000001047 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0000149 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0000005747 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000001257 Informative Direct
Molecular Function (MF) deacetylase activity 0.00000000000004834 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0001774 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0.0004229 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0007628 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.002007Moderately InformativeInherited
Enzyme Commission (EC)Alpha-mannosidase0Highly InformativeDirect
Enzyme Commission (EC)Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase0.000000000006568Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)renal/urinary system phenotype0.0008992Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0009658Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00000000000001527Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.004347Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.07028InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.1534InformativeInherited
Enzyme Commission (EC)Transferring other glycosyl groups0.00004645Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0.0009641Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.000000000000003232Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processSporulation0.0000001006InformativeDirect
Biological processLipid biosynthesis0.0000003109InformativeDirect
Biological processPolysaccharide degradation0.001453InformativeInherited
Biological processLipid A biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processNodulation0Highly InformativeDirect
Cellular componentGolgi apparatus0.00000000843Moderately InformativeDirect
Cellular componentSecreted0.001283Moderately InformativeInherited
Cellular componentLysosome0.000000003058InformativeDirect
Cellular componentCell wall0.00003067Highly InformativeDirect
DomainSignal0.000000000000007214Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000000008067InformativeDirect
Molecular functionZinc0.000000115Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0.000000000000007428InformativeDirect
Post-translational modificationGlycosyltransferase0.00002824InformativeDirect
Post-translational modificationGlycoprotein0.00000000004879Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)biopolymer biosynthesis2.278e-16Moderately InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0InformativeDirect
UniPathway (UP)protein glycosylation0.00000002956InformativeDirect
UniPathway (UP)glycolipid biosynthesis1InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011330 SSF88713 Protein matches
Abstract

This entry represents a structural motif found in glycoside hydrolase families 38 (, e.g. alpha-mannosidase) [PubMed12960159] and 57 (, e.g. 4-alpha-glucanotransferase, N-terminal) [PubMed12618437], as well as in NodB-like polysaccharide deacetylase and in some hypothetical proteins (e.g. TT1467, N-terminal domain). This domain consists of a 7-stranded beta/alpha barrel, although in some families the beta-barrels may be distorted and may vary in the number of strands.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycoside hydrolase/deacetylase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Glycoside hydrolase/deacetylase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]