SUPERFAMILY 1.75 HMM library and genome assignments server

Apolipoprotein A-II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Apolipoprotein A-II [ 82935]
Superfamily:   Apolipoprotein A-II [ 82936]
Families:   Apolipoprotein A-II [ 82937]


Superfamily statistics
Genomes (39) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 49 54 1
Proteins 49 54 1


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0000000032960.0000005193Least InformativeDirect
Biological Process (BP)protein metabolic process0.00000033530.000002022Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.000014180.000006329Least InformativeDirect
Biological Process (BP)regulation of cellular process0.44950.672Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0000000005870.0000006005Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.0000000011830.0000008606Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000000027380.000001975Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000000000076240.000000001132Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000000011650.000000002914Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00024130.001377Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.000029460.000005001InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.0000000000021080.000000004023InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.0000000000044770.000000006529InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process0.00000000000094780.00000000004359InformativeDirect
Biological Process (BP)regulation of cytokine biosynthetic process00Highly InformativeDirect
Molecular Function (MF)binding0.000005330.00006818Least InformativeDirect
Molecular Function (MF)protein dimerization activity0.0000000000037980.00000000003345InformativeDirect
Molecular Function (MF)protein heterodimerization activity00.00000000000002331Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0000005193 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000002022 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000006329 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.672 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000006005 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0000008606 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000001975 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000001132 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000002914 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.001377 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.000005001 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000004023 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000006529 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.00000000004359 Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Molecular Function (MF) binding 0.00006818 Least Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000003345 Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000000000002331 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid transport0InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0.0000000000007613Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Apolipoprotein A-II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Apolipoprotein A-II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]