SUPERFAMILY 1.75 HMM library and genome assignments server

Fumarate reductase respiratory complex transmembrane subunits superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Heme-binding four-helical bundle [ 81344] (3)
Superfamily:   Fumarate reductase respiratory complex transmembrane subunits [ 81343] (2)
Families:   Fumarate reductase respiratory complex cytochrome b subunit, FrdC [ 56910]
  Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) [ 81373] (4)


Superfamily statistics
Genomes (2,304) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,957 28,220 9
Proteins 4,956 28,212 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000033370.000005981Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.97030.9349Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.2180.2363Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.86790.8313Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.87480.8616Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0024850.1437Least InformativeInherited
Biological Process (BP)oxidation-reduction process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.041430.02679Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0030650.0004046Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.010930.0001083Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0040420.0005465Moderately InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.00000013940.00000005408InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process0.000010720.0000004291InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.000019550.000001531InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds00InformativeDirect
Biological Process (BP)phosphorylation0.00010780.0001379InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00002890.0000009707InformativeDirect
Biological Process (BP)oxidative phosphorylation0.0001020.0000000379Highly InformativeDirect
Biological Process (BP)electron transport chain0.0000000000006710Highly InformativeDirect
Biological Process (BP)aerobic respiration0.55470.4461Highly InformativeInherited
Molecular Function (MF)binding0.000034540.1937Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.000000013960.0000000001461Moderately InformativeDirect
Molecular Function (MF)electron carrier activity0.0000000059790.000000001604InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)cofactor binding00InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane00.000000000000008925Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00000000084490.000001465Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00000023640.0000004277Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0062480.00002201Least InformativeInherited
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)mitochondrial membrane part00InformativeDirect
Cellular Component (CC)respiratory chain00InformativeDirect
Cellular Component (CC)oxidoreductase complex00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000005981 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.9349 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2363 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8313 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.8616 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1437 Least Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.0004046 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001083 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0005465 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.02679 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.00000005408 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0000004291 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.000001531 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0 Informative Direct
Biological Process (BP) phosphorylation 0.0001379 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0000009707 Informative Direct
Biological Process (BP) oxidative phosphorylation 0.0000000379 Highly Informative Direct
Biological Process (BP) electron transport chain 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.4461 Highly Informative Inherited
Molecular Function (MF) binding 0.1937 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0000000001461 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 0.000000001604 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0.000000000000008925 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000001465 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00002201 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000004277 Least Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0 Informative Direct
Cellular Component (CC) respiratory chain 0 Informative Direct
Cellular Component (CC) oxidoreductase complex 0 Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processElectron transport0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCell membrane0.0000002035Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0.000000000000643InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.0000001235Moderately InformativeDirect
Molecular functionMetal-binding0.000000006837Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fumarate reductase respiratory complex transmembrane subunits domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Fumarate reductase respiratory complex transmembrane subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]