SUPERFAMILY 1.75 HMM library and genome assignments server


Fumarate reductase respiratory complex transmembrane subunits superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Heme-binding four-helical bundle [ 81344] (3)
Superfamily:   Fumarate reductase respiratory complex transmembrane subunits [ 81343] (2)
Families:   Fumarate reductase respiratory complex cytochrome b subunit, FrdC [ 56910]
  Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) [ 81373] (4)


Superfamily statistics
Genomes (2,300) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,979 28,220 9
Proteins 4,978 28,212 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process6.794e-081.145e-08Least InformativeDirect
Biological Process (BP)oxidation-reduction process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.030760.0182Moderately InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds00InformativeDirect
Biological Process (BP)phosphorylation3.936e-055.26e-05InformativeDirect
Biological Process (BP)oxidative phosphorylation0.00027863.244e-07Highly InformativeDirect
Biological Process (BP)electron transport chain0.00018696.139e-05Highly InformativeDirect
Biological Process (BP)aerobic respiration0.57590.454Highly InformativeInherited
Molecular Function (MF)binding4.341e-050.1855Least InformativeInherited
Molecular Function (MF)oxidoreductase activity9.536e-081.041e-09Moderately InformativeDirect
Molecular Function (MF)electron carrier activity1.377e-101.399e-11InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)cofactor binding00InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane02.499e-14Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle1.952e-092.444e-06Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)intracellular organelle part2.385e-076.605e-07Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0052851.448e-05Least InformativeInherited
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)mitochondrial membrane part00InformativeDirect
Cellular Component (CC)respiratory chain00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 1.145e-08 Least Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0182 Moderately Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0 Informative Direct
Biological Process (BP) phosphorylation 5.26e-05 Informative Direct
Biological Process (BP) oxidative phosphorylation 3.244e-07 Highly Informative Direct
Biological Process (BP) electron transport chain 6.139e-05 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.454 Highly Informative Inherited
Molecular Function (MF) binding 0.1855 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1.041e-09 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 1.399e-11 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) membrane 2.499e-14 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 2.444e-06 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.448e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 6.605e-07 Least Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0 Informative Direct
Cellular Component (CC) respiratory chain 0 Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCell membrane2.281e-07Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane6.713e-13InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide1.05e-07Moderately InformativeDirect
Molecular functionMetal-binding3.145e-09Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fumarate reductase respiratory complex transmembrane subunits domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Fumarate reductase respiratory complex transmembrane subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]