SUPERFAMILY 1.75 HMM library and genome assignments server


Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (473) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 70,760 96,641 43
Proteins 69,777 95,800 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)regulation of cellular process7.996e-092.31e-13Least InformativeDirect
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.24440Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)system process00Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.75360.001551Moderately InformativeInherited
Biological Process (BP)homeostatic process0.49260Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.46580.06802Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.86030.3992Moderately InformativeInherited
Biological Process (BP)regulation of localization16.581e-10Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)ion transport10.5345Moderately InformativeInherited
Biological Process (BP)organic substance transport11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function10.9738Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process10.0279Moderately InformativeInherited
Biological Process (BP)gene expression11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)RNA metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance10.1449Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)immune system process0.48970.07388Moderately InformativeInherited
Biological Process (BP)positive regulation of signal transduction5.02e-050InformativeDirect
Biological Process (BP)positive regulation of phosphorus metabolic process0.00092690InformativeDirect
Biological Process (BP)regulation of protein localization10.08341InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.41740.03288InformativeInherited
Biological Process (BP)cellular cation homeostasis0.063778.164e-14InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound10.9315InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.0012060InformativeInherited
Biological Process (BP)positive regulation of transport0.57880InformativeInherited
Biological Process (BP)response to cytokine stimulus11InformativeInherited
Biological Process (BP)nitrogen compound transport11InformativeInherited
Biological Process (BP)secretion0.69192.304e-10InformativeInherited
Biological Process (BP)regulation of hormone levels0.89831InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.042630InformativeInherited
Biological Process (BP)regulation of intracellular transport0.41051InformativeInherited
Biological Process (BP)regulation of secretion0.0094220InformativeInherited
Biological Process (BP)transcription, DNA-dependent0.0058681InformativeInherited
Biological Process (BP)regulation of immune response0.42521InformativeInherited
Biological Process (BP)regulation of immune effector process0.7231InformativeInherited
Biological Process (BP)positive regulation of immune system process0.12890.919InformativeInherited
Biological Process (BP)regulation of cytokine production0.5863.867e-05InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.31211.925e-07InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.63280.01276InformativeInherited
Biological Process (BP)negative regulation of cellular metabolic process11InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)cell activation0.097990.003493InformativeInherited
Biological Process (BP)regulation of body fluid levels0.8821.374e-06InformativeInherited
Biological Process (BP)regulation of system process0.3980InformativeInherited
Biological Process (BP)response to light stimulus0.16370.007989InformativeInherited
Biological Process (BP)response to external stimulus11InformativeInherited
Biological Process (BP)locomotion0.0017856.253e-07InformativeInherited
Biological Process (BP)localization of cell0.10578.581e-05InformativeInherited
Biological Process (BP)cellular component movement0.48140.975InformativeInherited
Biological Process (BP)sexual reproduction0.72661InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.77980.7162InformativeInherited
Biological Process (BP)single organism reproductive process0.96081InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.99061InformativeInherited
Biological Process (BP)response to wounding0.016530InformativeInherited
Biological Process (BP)defense response0.81363.63e-12InformativeInherited
Biological Process (BP)metal ion homeostasis0.0050080InformativeInherited
Biological Process (BP)regulation of growth11InformativeInherited
Biological Process (BP)sensory perception00Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade8.389e-080Highly InformativeDirect
Biological Process (BP)regulation of ERK1 and ERK2 cascade1.643e-063.145e-13Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis1.832e-050Highly InformativeDirect
Biological Process (BP)germ cell migration2.94e-050.0001369Highly InformativeDirect
Biological Process (BP)inflammatory response7.44e-050Highly InformativeDirect
Biological Process (BP)regulation of protein secretion0.2291.469e-11Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus11Highly InformativeInherited
Biological Process (BP)positive regulation of secretion0.45581.822e-07Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway11Highly InformativeInherited
Biological Process (BP)response to drug11Highly InformativeInherited
Biological Process (BP)hormone transport0.0037871.3e-05Highly InformativeInherited
Biological Process (BP)signal release0.059670.1562Highly InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport11Highly InformativeInherited
Biological Process (BP)transcription from RNA polymerase II promoter1.832e-051Highly InformativeInherited
Biological Process (BP)positive regulation of immune effector process0.24640.2092Highly InformativeInherited
Biological Process (BP)positive regulation of cell activation0.43380.7755Highly InformativeInherited
Biological Process (BP)hemostasis0.051251Highly InformativeInherited
Biological Process (BP)coagulation0.55610.1282Highly InformativeInherited
Biological Process (BP)wound healing0.85531Highly InformativeInherited
Biological Process (BP)activation of immune response0.039470.9114Highly InformativeInherited
Biological Process (BP)immune response-regulating signaling pathway11Highly InformativeInherited
Biological Process (BP)regulation of multicellular organism growth0.069480.004118Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)organic cyclic compound binding11Moderately InformativeInherited
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)receptor activity00InformativeDirect
Molecular Function (MF)lipid binding0.96940.02357InformativeInherited
Molecular Function (MF)odorant binding00Highly InformativeDirect
Molecular Function (MF)G-protein coupled receptor activity4.579e-060Highly InformativeDirect
Molecular Function (MF)peptide binding0.00018750Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.21240.001377Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection0.0094091.58e-08Moderately InformativeInherited
Cellular Component (CC)integral to membrane00InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane04.867e-14InformativeDirect
Cellular Component (CC)cell projection part0.00055973.806e-05InformativeDirect
Cellular Component (CC)cilium part09.13e-15Highly InformativeDirect
Cellular Component (CC)nonmotile primary cilium00.02023Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.31e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.581e-10 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.5345 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001551 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.9738 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.0279 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07388 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1449 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.06802 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3992 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.7793 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03177 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 0 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0 Informative Direct
Biological Process (BP) locomotion 6.253e-07 Informative Direct
Biological Process (BP) metal ion homeostasis 0 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 8.164e-14 Informative Direct
Biological Process (BP) localization of cell 8.581e-05 Informative Direct
Biological Process (BP) regulation of locomotion 1.402e-13 Informative Direct
Biological Process (BP) regulation of ion transport 1.341e-06 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 1.925e-07 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 9.145e-10 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) regulation of cytokine production 3.867e-05 Informative Direct
Biological Process (BP) secretion 2.304e-10 Informative Direct
Biological Process (BP) multi-organism reproductive process 6.918e-05 Informative Direct
Biological Process (BP) defense response 3.63e-12 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.374e-06 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 8.333e-08 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 7.681e-13 Informative Direct
Biological Process (BP) regulation of nervous system development 0.02772 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.1136 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.03288 Informative Inherited
Biological Process (BP) regulation of protein localization 0.08341 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9315 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.00884 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.8215 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2004 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cell proliferation 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.01276 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) metal ion transport 0.1107 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.3198 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.4825 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.01091 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.5661 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7162 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.01117 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.09799 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.01675 Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1593 Informative Inherited
Biological Process (BP) cellular component movement 0.975 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.919 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) response to lipid 0.4562 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001904 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002609 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of response to stress 0.8458 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.9022 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.105 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) lipid transport 0.4926 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to other organism 0.01229 Informative Inherited
Biological Process (BP) response to light stimulus 0.007989 Informative Inherited
Biological Process (BP) protein transport 0.8914 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.08187 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.9271 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.004892 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) cell activation 0.003493 Informative Inherited
Biological Process (BP) immune effector process 0.1084 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.3608 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) protein phosphorylation 1 Informative Inherited
Biological Process (BP) sensory perception 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 3.145e-13 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) germ cell migration 0.0001369 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) hormone transport 1.3e-05 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 1.392e-08 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 2.212e-13 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 1.133e-10 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 1.752e-06 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 4.448e-11 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 4.351e-09 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.196e-08 Highly Informative Direct
Biological Process (BP) calcium ion transport 9.875e-11 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 1.387e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 4.032e-14 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00058 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 3.207e-11 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 1.469e-11 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 6.379e-10 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 7.137e-05 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 3.877e-09 Highly Informative Direct
Biological Process (BP) digestion 1.142e-11 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 1.822e-07 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 3.389e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.158e-14 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 8.55e-07 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) feeding behavior 3.439e-11 Highly Informative Direct
Biological Process (BP) response to alkaloid 2.19e-10 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 5.038e-10 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 8.069e-10 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.641e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0001872 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0003873 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0005967 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.2029 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01686 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.01559 Highly Informative Inherited
Biological Process (BP) cellular response to peptide hormone stimulus 0.3244 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 1 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.8235 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) lipid homeostasis 1 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.03073 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.4596 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.005277 Highly Informative Inherited
Biological Process (BP) adult behavior 0.00177 Highly Informative Inherited
Biological Process (BP) signal release 0.1562 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.02488 Highly Informative Inherited
Biological Process (BP) response to drug 1 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.131 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.1235 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.02585 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.2092 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.7755 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.08099 Highly Informative Inherited
Biological Process (BP) regulation of blood coagulation 0.361 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) coagulation 0.1282 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.09317 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.1956 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.002214 Highly Informative Inherited
Biological Process (BP) learning or memory 0.1188 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.8615 Highly Informative Inherited
Biological Process (BP) gastrulation 0.07978 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.1153 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1318 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.2897 Highly Informative Inherited
Biological Process (BP) protein import 0.4478 Highly Informative Inherited
Biological Process (BP) peptidyl-tyrosine phosphorylation 0.03427 Highly Informative Inherited
Biological Process (BP) diol metabolic process 0.01308 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.1493 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.0768 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.9114 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) T cell activation 0.00567 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.4096 Highly Informative Inherited
Biological Process (BP) vascular process in circulatory system 0.03301 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.004118 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.02357 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.8273 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.9553 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 4.083e-10 Highly Informative Direct
Molecular Function (MF) phospholipase activity 4.476e-06 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 2.728e-05 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0.001377 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.842 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.58e-08 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 4.867e-14 Informative Direct
Cellular Component (CC) cell projection part 3.806e-05 Informative Direct
Cellular Component (CC) cell surface 0.0001766 Informative Direct
Cellular Component (CC) synapse 0.01602 Informative Inherited
Cellular Component (CC) nuclear envelope 0.3266 Informative Inherited
Cellular Component (CC) cilium part 9.13e-15 Highly Informative Direct
Cellular Component (CC) receptor complex 7.12e-08 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0001403 Highly Informative Direct
Cellular Component (CC) nonmotile primary cilium 0.02023 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.716Least InformativeInherited
Disease Ontology (DO)lung disease0.0003656Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.01032Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.04906Moderately InformativeInherited
Disease Ontology (DO)brain disease0.3632Moderately InformativeInherited
Disease Ontology (DO)cognitive disorder0.653Moderately InformativeInherited
Disease Ontology (DO)overnutrition9.667e-06InformativeDirect
Disease Ontology (DO)migraine2.139e-05InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2299InformativeInherited
Disease Ontology (DO)substance dependence0.3515InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.5224InformativeInherited
Disease Ontology (DO)eating disorder3.451e-05Highly InformativeDirect
Disease Ontology (DO)anxiety disorder0.0004288Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.005484Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.0001799Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007518Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.05136Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1111Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2401Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype3.597e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level1.805e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology3.593e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0.09607Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.17Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2885Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.329Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.4201Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.5499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.5513Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.6557Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.6982Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid level0.7961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.8883Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception2.454e-07InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior1.229e-05InformativeDirect
Mammalian Phenotype (MP)abnormal circulating hormone level2.097e-05InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic7.162e-05InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.0009487InformativeDirect
Mammalian Phenotype (MP)abnormal cell migration0.005682InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.01055InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.02551InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.07453InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2025InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.2318InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.3143InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.9224InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.9747InformativeInherited
Mammalian Phenotype (MP)increased body weight7.659e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness6.9e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to addictive substance0.0003733Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.002373Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory lobe morphology0.004773Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.02192Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)sterile progeny0.0005795Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant1Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.0004204InformativeDirect
Worm Phenotype (WP)egg laying variant0.3517InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)locomotor coordination variant1InformativeInherited
Worm Phenotype (WP)pharyngeal pumping variant0.3662Highly InformativeInherited
Worm Phenotype (WP)egg laying defective1Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0001669Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage2.363e-07Least InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

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