SUPERFAMILY 1.75 HMM library and genome assignments server


Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (443) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,169 2,602 4
Proteins 3,134 2,589 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.308e-11 Least Informative Direct
Biological Process (BP) protein metabolic process 1.244e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 2.666e-07 Least Informative Direct
Biological Process (BP) developmental process 1.913e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.645e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00113 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.003394 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1058 Least Informative Inherited
Biological Process (BP) localization 0.4904 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 2.258e-14 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 1.302e-11 Moderately Informative Direct
Biological Process (BP) reproduction 2.691e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 4.599e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002878 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.4729 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4324 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1965 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5821 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.194 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1255 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1821 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.195 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.6921 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8549 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2001 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.002661 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02411 Moderately Informative Inherited
Biological Process (BP) system process 0.7132 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01127 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.6939 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 7.835e-15 Informative Direct
Biological Process (BP) cell cycle process 6.362e-11 Informative Direct
Biological Process (BP) apoptotic process 5.8e-09 Informative Direct
Biological Process (BP) single organism reproductive process 7.388e-05 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0001417 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0004903 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0008216 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.0387 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.0624 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.267 Informative Inherited
Biological Process (BP) actin filament-based process 0.0163 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1298 Informative Inherited
Biological Process (BP) synaptic transmission 0.03144 Informative Inherited
Biological Process (BP) regulation of growth 0.005912 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.007686 Informative Inherited
Biological Process (BP) sexual reproduction 0.1276 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.07636 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1611 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1652 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.01302 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01761 Informative Inherited
Biological Process (BP) regulation of cell development 0.8201 Informative Inherited
Biological Process (BP) cellular membrane organization 0.01317 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.007034 Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 1.468e-11 Highly Informative Direct
Biological Process (BP) nuclear division 2.595e-08 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 4.058e-08 Highly Informative Direct
Biological Process (BP) vesicle organization 3.2e-07 Highly Informative Direct
Biological Process (BP) cell division 7.597e-07 Highly Informative Direct
Biological Process (BP) cell cycle phase 4.205e-06 Highly Informative Direct
Biological Process (BP) organelle localization 7.11e-06 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 4.469e-05 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001247 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0003643 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.000612 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.1055 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3205 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.0113 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.1511 Highly Informative Inherited
Molecular Function (MF) binding 1.464e-05 Least Informative Direct
Molecular Function (MF) protein binding 1.006e-09 Moderately Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3025 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5782 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7822 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.02741 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1455 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0007402 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 2.033e-08 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0004125 Highly Informative Direct
Cellular Component (CC) spindle 0.001175 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.5694Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.08872InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0002785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001038Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.5049Moderately InformativeInherited
Worm Phenotype (WP)life span variant4.34e-08InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis4.848e-05InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased4.147e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.02273Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.009259InformativeInherited
Fly Anatomy (FA)germline cyst0.01952InformativeInherited
Fly Anatomy (FA)follicle cell0.0003434Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8044Least InformativeInherited
Biological processCell cycle1.764e-09Moderately InformativeDirect
Biological processHost-virus interaction0.0001387Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis7.254e-06InformativeDirect
Biological processER-Golgi transport1.893e-11Highly InformativeDirect
Cellular componentNucleus1.197e-08Least InformativeDirect
Cellular componentGolgi apparatus3.744e-08Moderately InformativeDirect
Coding sequence diversityAlternative splicing2.722e-05Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]