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Frizzled cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Families:   Frizzled cysteine-rich domain [ 63502] (2)

Superfamily statistics
Genomes (149) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,061 2,002 2
Proteins 1,882 1,850 2

 Functional annotation
General category Regulation
Detailed category Signal transduction

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.163e-06 Least Informative Direct
Biological Process (BP) response to stimulus 5.152e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.07953 Least Informative Inherited
Biological Process (BP) localization 0.3205 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01974 Least Informative Inherited
Biological Process (BP) reproduction 0.0006725 Moderately Informative Direct
Biological Process (BP) signal transduction 8.734e-13 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.354e-05 Moderately Informative Direct
Biological Process (BP) tissue development 4.101e-05 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 6.252e-06 Moderately Informative Direct
Biological Process (BP) regulation of signaling 2.136e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 4.879e-10 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000756 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.394e-05 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 5.076e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.006804 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.007768 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5505 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.5658 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9319 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.3584 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.03036 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06692 Moderately Informative Inherited
Biological Process (BP) immune system process 0.05971 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1201 Moderately Informative Inherited
Biological Process (BP) gene expression 0.8003 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5212 Moderately Informative Inherited
Biological Process (BP) organ development 0.1268 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1085 Moderately Informative Inherited
Biological Process (BP) cell activation 0.0003667 Informative Direct
Biological Process (BP) sensory organ development 1.906e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 9.445e-08 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0007847 Informative Direct
Biological Process (BP) biological adhesion 0.0008442 Informative Direct
Biological Process (BP) negative regulation of signaling 4.784e-08 Informative Direct
Biological Process (BP) cellular component morphogenesis 7.216e-05 Informative Direct
Biological Process (BP) response to lipid 5.407e-05 Informative Direct
Biological Process (BP) growth 2.426e-05 Informative Direct
Biological Process (BP) locomotion 1.2e-05 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00027 Informative Direct
Biological Process (BP) regulation of apoptotic process 6.902e-05 Informative Direct
Biological Process (BP) embryonic organ development 0.0007958 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.333e-06 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.156e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 3.18e-07 Informative Direct
Biological Process (BP) generation of neurons 3.931e-09 Informative Direct
Biological Process (BP) tissue morphogenesis 3.822e-09 Informative Direct
Biological Process (BP) epithelium development 5.275e-05 Informative Direct
Biological Process (BP) cardiovascular system development 0.0002041 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2701 Informative Inherited
Biological Process (BP) regulation of protein localization 0.3573 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.6709 Informative Inherited
Biological Process (BP) cell proliferation 0.01619 Informative Inherited
Biological Process (BP) tube development 0.006053 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6011 Informative Inherited
Biological Process (BP) regulation of response to stress 0.3491 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.01709 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4169 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1206 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5493 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.03282 Informative Inherited
Biological Process (BP) central nervous system development 0.1129 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01076 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.009707 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.03886 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.002577 Informative Inherited
Biological Process (BP) cellular component movement 0.07968 Informative Inherited
Biological Process (BP) localization of cell 0.00107 Informative Inherited
Biological Process (BP) reproductive system development 0.449 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.4317 Informative Inherited
Biological Process (BP) cell projection organization 0.08336 Informative Inherited
Biological Process (BP) chordate embryonic development 0.08038 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.0007699 Highly Informative Direct
Biological Process (BP) pattern specification process 2.07e-06 Highly Informative Direct
Biological Process (BP) axonogenesis 0.0001223 Highly Informative Direct
Biological Process (BP) gonad development 0.0001497 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.0003765 Highly Informative Direct
Biological Process (BP) protein processing 9.829e-06 Highly Informative Direct
Biological Process (BP) hair cycle process 1.437e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 4.453e-05 Highly Informative Direct
Biological Process (BP) lymphocyte differentiation 1.503e-06 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 2.07e-05 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 4.774e-05 Highly Informative Direct
Biological Process (BP) tube formation 4.218e-05 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.0003839 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 2.554e-05 Highly Informative Direct
Biological Process (BP) developmental growth 0.0002162 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 2.049e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.108e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0002888 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 3.132e-05 Highly Informative Direct
Biological Process (BP) gastrulation 0.5086 Highly Informative Inherited
Biological Process (BP) T cell activation 0.1048 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.01551 Highly Informative Inherited
Biological Process (BP) stem cell development 0.01228 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.01515 Highly Informative Inherited
Biological Process (BP) epidermis development 0.4376 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.08246 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.9445 Highly Informative Inherited
Biological Process (BP) ossification 0.002791 Highly Informative Inherited
Molecular Function (MF) binding 0.0001786 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.5911 Least Informative Inherited
Molecular Function (MF) protein binding 1.285e-08 Moderately Informative Direct
Molecular Function (MF) receptor activity 1.754e-14 Informative Direct
Molecular Function (MF) peptidase activity 3.422e-05 Informative Direct
Molecular Function (MF) molecular transducer activity 7.525e-14 Informative Direct
Cellular Component (CC) membrane 2.155e-13 Least Informative Direct
Cellular Component (CC) extracellular region 3.67e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 3.218e-10 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.6187 Moderately Informative Inherited
Cellular Component (CC) cell surface 6.624e-07 Informative Direct
Cellular Component (CC) integral to membrane 1.612e-06 Informative Direct
Cellular Component (CC) extracellular matrix 9.294e-07 Informative Direct
Cellular Component (CC) cell leading edge 2.398e-05 Informative Direct
Cellular Component (CC) cell projection part 6.918e-06 Informative Direct
Cellular Component (CC) neuron part 0.0006932 Informative Direct
Cellular Component (CC) cell projection membrane 9.298e-08 Highly Informative Direct
Cellular Component (CC) leading edge membrane 3.411e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08138Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.005928Moderately InformativeInherited
Disease Ontology (DO)myeloma0.0001478InformativeDirect
Disease Ontology (DO)myeloid leukemia0.0009517InformativeDirect
Disease Ontology (DO)multiple myeloma1.289e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0009474Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.004719Least InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype0.002377Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.245Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3639Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.5153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5241Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.6596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.0005335InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.0005335InformativeDirect
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.001717InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01961InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.02028InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.04944InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue morphology0.09567InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.6519InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure7.443e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles5.928e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal somite size0.0001124Highly InformativeDirect
Mammalian Phenotype (MP)impaired somite development0.001863Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.007713Highly InformativeInherited
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.01065Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gastrulation0.1194Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.03905Least InformativeInherited
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)cell migration variant6.718e-05InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001549InformativeDirect
Worm Phenotype (WP)nervous system development variant0Highly InformativeDirect
Worm Phenotype (WP)neuron migration variant1.244e-11Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)thoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)anatomical group0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)prepupa0InformativeDirect
Fly Anatomy (FA)pupa0InformativeDirect
Fly Anatomy (FA)germline cyst0InformativeDirect
Fly Anatomy (FA)ovariole0InformativeDirect
Fly Anatomy (FA)mechanosensory sensory organ0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)eye photoreceptor cell0InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0InformativeDirect
Fly Anatomy (FA)imaginal disc0Highly InformativeDirect
Fly Anatomy (FA)follicle cell0Highly InformativeDirect
Fly Anatomy (FA)mechanosensory chaeta0Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.003597Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.05194Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.09966Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.211Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2676Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.6513Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure6.224e-08Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.001283Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.001627Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.01399Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.04566Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate7.372e-13InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle1.135e-09InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction7.885e-09InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm9.027e-09InformativeDirect
Xenopus ANatomical entity (XAN)primordium3.843e-07InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region2.575e-05InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0001394InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0003751InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003922InformativeDirect
Xenopus ANatomical entity (XAN)tail0.2507InformativeInherited
Xenopus ANatomical entity (XAN)liver and biliary system0.593InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.6144InformativeInherited
Xenopus ANatomical entity (XAN)midbrain4.387e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme2.197e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field4.325e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate2.689e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain2.71e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm7.462e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal arch2.268e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain2.834e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut3.609e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)fin3.923e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric duct5.142e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium5.544e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region8.321e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0001044Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.000142Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0002969Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0003108Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0005733Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted2.572e-12Moderately InformativeDirect
Cellular componentCell membrane2.736e-05Moderately InformativeDirect
Cellular componentGolgi apparatus0.0003949Moderately InformativeDirect
Cellular componentExtracellular matrix0.000705InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1.053e-11Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationUbl conjugation3.026e-13Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000024 SSF63501 Protein matches
Abstract The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases [PubMed9637908, PubMed9684897, PubMed9852758]. In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases, which have roles in development include the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges. These are shown in schematic form below: 
        +--------------+
        |              |
--C--C--C--C--C--C--C--C--C--C--
  |  |     |  |  |  |     |  |
  |  +-----+  |  |  +-----+  |
  +-----------+  +-----------+

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Frizzled cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.