SUPERFAMILY 1.75 HMM library and genome assignments server

Frizzled cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Families:   Frizzled cysteine-rich domain [ 63502] (2)


Superfamily statistics
Genomes (174) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,204 2,436 2
Proteins 2,063 2,270 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00002196 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000007609 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.06328 Least Informative Inherited
Biological Process (BP) localization 0.2034 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02231 Least Informative Inherited
Biological Process (BP) reproduction 0.0005007 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000000000001275 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00001183 Moderately Informative Direct
Biological Process (BP) tissue development 0.000003847 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000004318 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00001149 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0026 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01826 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8624 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1859 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2571 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3797 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.5238 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.04059 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.03453 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.03124 Moderately Informative Inherited
Biological Process (BP) immune system process 0.06642 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0937 Moderately Informative Inherited
Biological Process (BP) gene expression 0.645 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.09126 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1129 Moderately Informative Inherited
Biological Process (BP) sensory organ development 0.00002711 Informative Direct
Biological Process (BP) response to wounding 0.0004858 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000005947 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0004369 Informative Direct
Biological Process (BP) biological adhesion 0.0006746 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000002782 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001516 Informative Direct
Biological Process (BP) response to lipid 0.00005769 Informative Direct
Biological Process (BP) growth 0.00001905 Informative Direct
Biological Process (BP) locomotion 0.000002195 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00003919 Informative Direct
Biological Process (BP) embryonic organ development 0.000007048 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000000533 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0000008941 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00004433 Informative Direct
Biological Process (BP) generation of neurons 0.0000000002053 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000000004063 Informative Direct
Biological Process (BP) localization of cell 0.00005567 Informative Direct
Biological Process (BP) epithelium development 0.0001713 Informative Direct
Biological Process (BP) cardiovascular system development 0.0001185 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.349 Informative Inherited
Biological Process (BP) regulation of protein localization 0.2285 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.6541 Informative Inherited
Biological Process (BP) cell projection organization 0.1008 Informative Inherited
Biological Process (BP) tube development 0.003346 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5785 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.007201 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.02059 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3366 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1794 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6354 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.06557 Informative Inherited
Biological Process (BP) central nervous system development 0.05309 Informative Inherited
Biological Process (BP) regulation of locomotion 0.02327 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02208 Informative Inherited
Biological Process (BP) leukocyte activation 0.004579 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.09275 Informative Inherited
Biological Process (BP) cellular component movement 0.0266 Informative Inherited
Biological Process (BP) reproductive system development 0.5399 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.5767 Informative Inherited
Biological Process (BP) organ morphogenesis 0.001671 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8589 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0002221 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0001197 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0007793 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00000176 Highly Informative Direct
Biological Process (BP) gonad development 0.0002121 Highly Informative Direct
Biological Process (BP) protein processing 0.000004419 Highly Informative Direct
Biological Process (BP) neural tube development 0.0000001805 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.00002901 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.00001495 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.00003478 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.0001429 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0003708 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00001147 Highly Informative Direct
Biological Process (BP) developmental growth 0.0003817 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0000148 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000001694 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0005946 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.00006207 Highly Informative Direct
Biological Process (BP) neuron projection development 0.2255 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.03505 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.0178 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1253 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.01069 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.03512 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.01168 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.1089 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.003228 Highly Informative Inherited
Biological Process (BP) ossification 0.004606 Highly Informative Inherited
Molecular Function (MF) binding 0.00000001943 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.3048 Least Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0.000003284 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000000000000001562 Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000003238 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0004317 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.1331 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000000000004673 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000001225 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.1189 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.002553 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.0000001562 Informative Direct
Cellular Component (CC) integral to membrane 0.00000004949 Informative Direct
Cellular Component (CC) extracellular matrix 0.000000184 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1094Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.003743Moderately InformativeInherited
Disease Ontology (DO)myeloma0.00009432InformativeDirect
Disease Ontology (DO)myeloid leukemia0.0006426InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.002031Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007233Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.06602Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.07639Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3515Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5548Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.6338Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.0007308InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.0007308InformativeDirect
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.002175InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.01022InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.04752InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.05667InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.612InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.000001174Highly InformativeDirect
Mammalian Phenotype (MP)fused somites0.000002076Highly InformativeDirect
Mammalian Phenotype (MP)diluted coat color0.000007904Highly InformativeDirect
Mammalian Phenotype (MP)decreased somite size0.00005451Highly InformativeDirect
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.0000839Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0002487Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension0.000512Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.01046Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.03905Least InformativeInherited
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)cell migration variant0.00006718InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001549InformativeDirect
Worm Phenotype (WP)nervous system development variant0Highly InformativeDirect
Worm Phenotype (WP)neuron migration variant0.00000000001244Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)thoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0Moderately InformativeDirect
Fly Anatomy (FA)adult sense organ0Moderately InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)external sensory organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)sensillum0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)epithelial cell0InformativeDirect
Fly Anatomy (FA)prepupa0InformativeDirect
Fly Anatomy (FA)pupa0InformativeDirect
Fly Anatomy (FA)optic lobe neuron0InformativeDirect
Fly Anatomy (FA)ommatidium0InformativeDirect
Fly Anatomy (FA)germline cyst0InformativeDirect
Fly Anatomy (FA)ovariole0InformativeDirect
Fly Anatomy (FA)imaginal precursor0InformativeDirect
Fly Anatomy (FA)mechanosensory sensory organ0InformativeDirect
Fly Anatomy (FA)sensory organ cell0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0InformativeDirect
Fly Anatomy (FA)rhabdomeric photoreceptor cell0InformativeDirect
Fly Anatomy (FA)histaminergic neuron0InformativeDirect
Fly Anatomy (FA)follicle cell0Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.004333Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.0525Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.104Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.2203Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.267Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.6495Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0000001591Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.001913Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.002071Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0501Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9652Moderately InformativeInherited
Xenopus ANatomical entity (XAN)intestine1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.000000000009928InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0000000004801InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.00000001982InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000004746InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.00000008734InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0000001561InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0000004438InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0000006719InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00001325InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0000157InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000828InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001152InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0006353InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.000639InformativeDirect
Xenopus ANatomical entity (XAN)tail0.2707InformativeInherited
Xenopus ANatomical entity (XAN)liver and biliary system0.5938InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.6265InformativeInherited
Xenopus ANatomical entity (XAN)stomodeal-hypophyseal primordium0.0000000004468Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0000002829Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.0000003999Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000003599Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.000003675Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.00001332Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.00006321Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric duct0.0001185Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0001853Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.000294Highly InformativeDirect
Xenopus ANatomical entity (XAN)blood vessel0.0004282Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0004849Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0007121Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0.000000000002337Moderately InformativeDirect
Cellular componentCell membrane0.0000007569Moderately InformativeDirect
Cellular componentGolgi apparatus0.0004507Moderately InformativeDirect
Cellular componentExtracellular matrix0.0006644InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.0000000000003881Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000008844Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000024 SSF63501 Protein matches
Abstract The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases [PubMed9637908, PubMed9684897, PubMed9852758]. In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases, which have roles in development include the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges. These are shown in schematic form below:
        +--------------+
        |              |
--C--C--C--C--C--C--C--C--C--C--
  |  |     |  |  |  |     |  |
  |  +-----+  |  |  +-----+  |
  +-----------+  +-----------+

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Frizzled cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]