SUPERFAMILY 1.75 HMM library and genome assignments server

Apolipoprotein A-I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Apolipoprotein A-I [ 58112]
Superfamily:   Apolipoprotein A-I [ 58113]
Families:   Apolipoprotein A-I [ 58114]


Superfamily statistics
Genomes (1,444) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,262 10,308 2
Proteins 2,879 9,318 2


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0000286 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00004393 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00008865 Least Informative Direct
Biological Process (BP) developmental process 0.1331 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8573 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.0807 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3453 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1844 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.005216 Least Informative Inherited
Biological Process (BP) localization 0.008255 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.226 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.0000000007169 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00000001001 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00000004466 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0000001434 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000002008 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000002091 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000008057 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00001931 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0006092 Moderately Informative Direct
Biological Process (BP) cellular localization 0.01323 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.009161 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.00194 Moderately Informative Inherited
Biological Process (BP) system process 0.07287 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.004801 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.06155 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01321 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.04505 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.07636 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4276 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000000002729 Informative Direct
Biological Process (BP) lipid catabolic process 0.0000001285 Informative Direct
Biological Process (BP) response to inorganic substance 0.000000251 Informative Direct
Biological Process (BP) cell projection organization 0.000001153 Informative Direct
Biological Process (BP) blood circulation 0.000002072 Informative Direct
Biological Process (BP) generation of neurons 0.000009195 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000112 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00002549 Informative Direct
Biological Process (BP) regulation of growth 0.0001565 Informative Direct
Biological Process (BP) response to wounding 0.0003416 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0004494 Informative Direct
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.5161 Informative Inherited
Biological Process (BP) cardiovascular system development 0.009897 Informative Inherited
Biological Process (BP) regulation of system process 0.01754 Informative Inherited
Biological Process (BP) protein catabolic process 0.01492 Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.000000000000005594 Highly Informative Direct
Biological Process (BP) response to axon injury 0.0000000000003256 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.00000000003934 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.0000000005942 Highly Informative Direct
Biological Process (BP) steroid catabolic process 0.000000004249 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00000003892 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000005352 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.000001132 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.00005583 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.00007783 Highly Informative Direct
Molecular Function (MF) binding 0.09623 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0000001309 Moderately Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) lipid binding 0.000001176 Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.000000000000203 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) endosome 0.001434 Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.002359Moderately InformativeInherited
Disease Ontology (DO)heart disease0InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0InformativeDirect
Disease Ontology (DO)atherosclerosis0InformativeDirect
Disease Ontology (DO)coronary artery disease0InformativeDirect
Disease Ontology (DO)overnutrition0InformativeDirect
Disease Ontology (DO)glucose metabolism disease1InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cholesterol level0InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0InformativeDirect
Mammalian Phenotype (MP)decreased cholesterol level0.2359Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)kidney0InformativeDirect
Xenopus ANatomical entity (XAN)stomach0Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesonephric kidney0Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001592InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainCoiled coil0.0003906Moderately InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationGlycoprotein0.000001602Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Apolipoprotein A-I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Apolipoprotein A-I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]