SUPERFAMILY 1.75 HMM library and genome assignments server

Bacterial hemolysins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Antiparallel coiled-coil [ 58086] (17)
Superfamily:   Bacterial hemolysins [ 58100] (2)
Families:   Hemolysin E (HlyE, ClyA, SheA) [ 58101]
  HBL-like [ 161263]

Superfamily statistics
Genomes (625) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,146 6,550 2
Proteins 1,130 6,530 2

Functional annotation
General category coiled coil
Detailed category The code refers to a 3-helix_alpha_sheet in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Function annotation of SCOP domain superfamilies

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCytolysis0.0000000000001083InformativeDirect
Biological processHemolysis0.00000000000001495Highly InformativeDirect
Cellular componentMembrane0.00002492Least InformativeDirect
Cellular componentSecreted0.000324Moderately InformativeDirect
Cellular componentHost membrane0.0000003529InformativeDirect
DomainTransmembrane0.003827Least InformativeInherited
Post-translational modificationToxin0.000000000002616InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Bacterial hemolysins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Bacterial hemolysins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · UniProtKB KeyWords (KW) · Internal database links ]