SUPERFAMILY 1.75 HMM library and genome assignments server

Clostridium neurotoxins, "coiled-coil" domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Antiparallel coiled-coil [ 58086] (17)
Superfamily:   Clostridium neurotoxins, "coiled-coil" domain [ 58091]
Families:   Clostridium neurotoxins, "coiled-coil" domain [ 58092]


Superfamily statistics
Genomes (15) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 30 248 2
Proteins 30 248 2


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000005048 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0001086 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002729 Least Informative Inherited
Biological Process (BP) system process 0.000000001119 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000000597 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00008616 Moderately Informative Direct
Biological Process (BP) secretion by cell 0.00000000000001435 Informative Direct
Biological Process (BP) synaptic transmission 0.0000000000004892 Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) signal release 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00000327 Least Informative Direct
Molecular Function (MF) peptidase activity 0.0000000001468 Informative Direct
Molecular Function (MF) metallopeptidase activity 0.000000000000001562 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.000000000001518 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Bontoxilysin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0InformativeDirect
Cellular componentMembrane0.000009951Least InformativeDirect
Cellular componentSecreted0.000000000001572Moderately InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
DomainTransmembrane0.00000009223Least InformativeDirect
Molecular functionZinc0.00000000001169Least InformativeDirect
Molecular functionMetal-binding0.000002829Least InformativeDirect
Post-translational modificationHydrolase0.0000001706Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationDisulfide bond0.000000000005725Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Clostridium neurotoxins, "coiled-coil" domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Clostridium neurotoxins, "coiled-coil" domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]