SUPERFAMILY 1.75 HMM library and genome assignments server

SNARE fusion complex superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   SNARE fusion complex [ 58038]
Families:   SNARE fusion complex [ 58039] (11)


Superfamily statistics
Genomes (508) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,388 11,953 29
Proteins 10,359 10,894 29


Functional annotation
General category coiled coil
Detailed category The code refers to 4-helix bundles. These are a type of structure which frequently contain coiled-coils.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.00000032080Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.000000000054120Least InformativeDirect
Biological Process (BP)regulation of cellular process0.29861Least InformativeInherited
Biological Process (BP)response to stimulus0.15711Least InformativeInherited
Biological Process (BP)multicellular organismal process0.017570.9935Least InformativeInherited
Biological Process (BP)system process0.000043430.0000001522Moderately InformativeDirect
Biological Process (BP)cellular localization0.0000000000070370Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.62331Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.27611Moderately InformativeInherited
Biological Process (BP)regulation of localization0.13930.0008132Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.2050.557Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.75861Moderately InformativeInherited
Biological Process (BP)organic substance transport11Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.061970.1241Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.058040.4913Moderately InformativeInherited
Biological Process (BP)organelle organization0.010190.00000001282Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.010790.002093Moderately InformativeInherited
Biological Process (BP)synaptic transmission0.00000024390InformativeDirect
Biological Process (BP)protein transport0.0000029930.0000000000008197InformativeDirect
Biological Process (BP)cellular membrane organization0.000000069470InformativeDirect
Biological Process (BP)vesicle-mediated transport0.000000000031880InformativeDirect
Biological Process (BP)response to nutrient levels0.000085360.00006792InformativeDirect
Biological Process (BP)secretion by cell0.000000000020960InformativeDirect
Biological Process (BP)regulation of system process0.00047070.000002259InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.00070310.0000000000001225InformativeDirect
Biological Process (BP)organelle localization0.2680.08149InformativeInherited
Biological Process (BP)cytoplasmic transport0.90010.003857InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.00000042360Highly InformativeDirect
Biological Process (BP)neurotransmitter transport0.000074990.0000000000006516Highly InformativeDirect
Biological Process (BP)exocytosis0.000021210.00000000000003956Highly InformativeDirect
Biological Process (BP)autophagy0.00000015560Highly InformativeDirect
Biological Process (BP)cellular response to starvation0.0000067460.00000002785Highly InformativeDirect
Biological Process (BP)vesicle organization0.00000000036140Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport0.00019340Highly InformativeDirect
Biological Process (BP)organelle fusion0.000000000000046520Highly InformativeDirect
Biological Process (BP)membrane fusion00Highly InformativeDirect
Biological Process (BP)establishment of synaptic vesicle localization0.000000012660.7973Highly InformativeInherited
Biological Process (BP)signal release0.32420.3483Highly InformativeInherited
Molecular Function (MF)binding0.000033990.000001051Least InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)protein complex0.0000000017280Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00013240Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00066421Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.21360.00001802Least InformativeInherited
Cellular Component (CC)plasma membrane0.000071540.000001015Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.00000015860Moderately InformativeDirect
Cellular Component (CC)vesicle0.0000009730Moderately InformativeDirect
Cellular Component (CC)endosome0.000000069850InformativeDirect
Cellular Component (CC)vacuolar part0.00000036350.000000000000008984InformativeDirect
Cellular Component (CC)synapse part0.0000044670InformativeDirect
Cellular Component (CC)lytic vacuole0.0000000068660.002663InformativeInherited
Cellular Component (CC)trans-Golgi network0.00091950.00000000009335Highly InformativeDirect
Cellular Component (CC)endosomal part0.000017510.00000000000007907Highly InformativeDirect
Cellular Component (CC)late endosome0.29690.0008542Highly InformativeInherited
Cellular Component (CC)lysosome0.62691Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9935 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) system process 0.0000001522 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000001282 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0008132 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.557 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002093 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1241 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4913 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) protein transport 0.0000000000008197 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.00006792 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) regulation of system process 0.000002259 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000000000001225 Informative Direct
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.05838 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1108 Informative Inherited
Biological Process (BP) regulation of secretion 0.01032 Informative Inherited
Biological Process (BP) organelle localization 0.08149 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.003857 Informative Inherited
Biological Process (BP) single-organism behavior 0.3738 Informative Inherited
Biological Process (BP) immune response 0.3458 Informative Inherited
Biological Process (BP) leukocyte activation 0.03495 Informative Inherited
Biological Process (BP) immune effector process 0.01431 Informative Inherited
Biological Process (BP) cell cycle process 0.9354 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000005509 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0000224 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.0000000000006516 Highly Informative Direct
Biological Process (BP) exocytosis 0.00000000000003956 Highly Informative Direct
Biological Process (BP) autophagy 0 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.00000002785 Highly Informative Direct
Biological Process (BP) vesicle organization 0 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.000000004283 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00000000007758 Highly Informative Direct
Biological Process (BP) membrane fusion 0 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.7973 Highly Informative Inherited
Biological Process (BP) signal release 0.3483 Highly Informative Inherited
Biological Process (BP) learning or memory 0.01329 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.6455 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.003399 Highly Informative Inherited
Biological Process (BP) cell division 0.07116 Highly Informative Inherited
Molecular Function (MF) binding 0.000001051 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.00439 Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001802 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00002846 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000001015 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000000005134 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.01168 Moderately Informative Inherited
Cellular Component (CC) cytosol 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) integral to membrane 0.00000005613 Informative Direct
Cellular Component (CC) neuron projection 0.0000001279 Informative Direct
Cellular Component (CC) vacuolar part 0.000000000000008984 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) coated vesicle 0.004307 Informative Inherited
Cellular Component (CC) lytic vacuole 0.002663 Informative Inherited
Cellular Component (CC) late endosome 0.0008542 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.00000000009335 Highly Informative Direct
Cellular Component (CC) endosomal part 0.00000000000007907 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.1577 Highly Informative Inherited
Cellular Component (CC) lysosome 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.03305Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.002081InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.03372Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.775Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.04081Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3933Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.4697Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.09515InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0000001015InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.000001874Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processNeurotransmitter transport0.0000000000001474Highly InformativeDirect
Biological processAutophagy0.000000000002345Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentSynaptosome0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0002857Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationAcetylation0.000000007043Least InformativeDirect
Post-translational modificationPhosphoprotein0.000008568Least InformativeDirect
Post-translational modificationMethylation0.000000188Moderately InformativeDirect
Post-translational modificationPalmitate0.00002435Moderately InformativeDirect
Post-translational modificationPrenylation0.0000000001248InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 20 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SNARE fusion complex domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 20 hidden Markov models representing the SNARE fusion complex superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]