SUPERFAMILY 1.75 HMM library and genome assignments server

Tropomyosin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Tropomyosin [ 57997]
Families:   Tropomyosin [ 57998]


Superfamily statistics
Genomes (1,711) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,895 22,668 8
Proteins 9,970 21,617 8


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00.00000002115Least InformativeDirect
Biological Process (BP)developmental process0.00000000029650.0001885Least InformativeDirect
Biological Process (BP)response to stimulus0.74341Least InformativeInherited
Biological Process (BP)single-organism cellular process0.97920.008357Least InformativeInherited
Biological Process (BP)regulation of cellular process0.7851Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.14160.000005382Least InformativeInherited
Biological Process (BP)tissue development0.90530.5754Moderately InformativeInherited
Biological Process (BP)regulation of localization0.089790.3132Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.038630.22Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.049270.8308Moderately InformativeInherited
Biological Process (BP)response to organic substance0.30331Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.047240.7139Moderately InformativeInherited
Biological Process (BP)cell differentiation0.049930.9154Moderately InformativeInherited
Biological Process (BP)organ development11Moderately InformativeInherited
Biological Process (BP)signal transduction0.39291Moderately InformativeInherited
Biological Process (BP)organelle organization0.0030080.00001534Moderately InformativeInherited
Biological Process (BP)system process0.0038870.0000008576Moderately InformativeInherited
Biological Process (BP)muscle system process00InformativeDirect
Biological Process (BP)cytoskeleton organization0.00032380.00007057InformativeDirect
Biological Process (BP)embryo development ending in birth or egg hatching0.000082180.0004311InformativeDirect
Biological Process (BP)actin filament-based process0.00000000065860.00000000007576InformativeDirect
Biological Process (BP)muscle tissue development0.0000011310.0000000006912InformativeDirect
Biological Process (BP)response to organic cyclic compound0.0046130.03835InformativeInherited
Biological Process (BP)single-organism behavior0.64160.7569InformativeInherited
Biological Process (BP)response to organonitrogen compound0.003130.1991InformativeInherited
Biological Process (BP)regulation of ion transport0.0040160.01253InformativeInherited
Biological Process (BP)positive regulation of transport0.011010.1762InformativeInherited
Biological Process (BP)muscle structure development0.011570.00000002562InformativeInherited
Biological Process (BP)cellular component movement0.0027370.0007033InformativeInherited
Biological Process (BP)muscle organ development0.00011720.00000004048Highly InformativeDirect
Biological Process (BP)actin filament-based movement0.00035610.0000001549Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.000097650.0002419Highly InformativeDirect
Biological Process (BP)response to alkaloid0.00000045120.00001749Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue0.000000036710.00000002275Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport0.00013540.00004995Highly InformativeDirect
Biological Process (BP)adult behavior0.0063490.02096Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.0010730.02911Highly InformativeInherited
Molecular Function (MF)binding0.0068550.01279Least InformativeInherited
Molecular Function (MF)structural molecule activity00Moderately InformativeDirect
Molecular Function (MF)cytoskeletal protein binding0.000026430.00008818InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0000001390.00001921Least InformativeDirect
Cellular Component (CC)intracellular organelle part00Least InformativeDirect
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection0.0000022920.000001017Moderately InformativeDirect
Cellular Component (CC)cell cortex0.0000000000046850.00000000005648InformativeDirect
Cellular Component (CC)actin cytoskeleton0.0000000000000014340InformativeDirect
Cellular Component (CC)contractile fiber part00InformativeDirect
Cellular Component (CC)neuron projection0.00021760.1593InformativeInherited
Cellular Component (CC)synapse part0.0015980.000000000001801InformativeInherited
Cellular Component (CC)growth cone0.00000010670.00000008795Highly InformativeDirect
Cellular Component (CC)cell division site part00Highly InformativeDirect
Cellular Component (CC)dendrite0.81581Highly InformativeInherited
Cellular Component (CC)sarcomere0.0010480.09229Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000002115 Least Informative Direct
Biological Process (BP) developmental process 0.0001885 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000005382 Least Informative Direct
Biological Process (BP) localization 0.03153 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.008357 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) system process 0.0000008576 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00001534 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000152 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.099 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1772 Moderately Informative Inherited
Biological Process (BP) tissue development 0.5754 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9154 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3132 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.22 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8308 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7139 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) cellular component movement 0.0007033 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00007057 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0004311 Informative Direct
Biological Process (BP) cell cycle process 0.0005539 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000007576 Informative Direct
Biological Process (BP) muscle tissue development 0.0000000006912 Informative Direct
Biological Process (BP) muscle structure development 0.00000002562 Informative Direct
Biological Process (BP) organelle localization 0.007611 Informative Inherited
Biological Process (BP) chromosome organization 0.6726 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.03777 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01104 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.004764 Informative Inherited
Biological Process (BP) synaptic transmission 0.02475 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.03835 Informative Inherited
Biological Process (BP) single-organism behavior 0.7569 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.1991 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01253 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1762 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07807 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2669 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.6412 Informative Inherited
Biological Process (BP) DNA metabolic process 0.07545 Informative Inherited
Biological Process (BP) chromosome segregation 0.00001025 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00000004048 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0006519 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.0000001549 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.0002097 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.0002419 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.00001749 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 0.00000002275 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00004995 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 0.0003413 Highly Informative Direct
Biological Process (BP) meiosis 0.1341 Highly Informative Inherited
Biological Process (BP) adult behavior 0.02096 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.02911 Highly Informative Inherited
Biological Process (BP) mitosis 0.04265 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.3611 Highly Informative Inherited
Molecular Function (MF) binding 0.01279 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00008818 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000623 Informative Direct
Molecular Function (MF) lipid binding 0.1283 Informative Inherited
Molecular Function (MF) enzyme binding 0.3551 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0.00000363 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.00000008244 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001921 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000001017 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.481 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.00000000005648 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) synapse part 0.000000000001801 Informative Direct
Cellular Component (CC) neuron projection 0.1593 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell junction 0.0186 Informative Inherited
Cellular Component (CC) extracellular matrix 0.005475 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) growth cone 0.00000008795 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0003455 Highly Informative Direct
Cellular Component (CC) dendrite 1 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.001354 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.09229 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.001961 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscular disease0.005608Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4824Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5123Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.000193Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.002956Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.06206Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.07432Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.08483Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.3641Moderately InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.00006323InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.003864InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.007143InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium0.01628InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.02409InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.03449InformativeInherited
Phenotypic Abnormality (PA)Abnormality of facial skeleton0.08697InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1127InformativeInherited
Phenotypic Abnormality (PA)Distal arthrogryposis0.000000199Highly InformativeDirect
Phenotypic Abnormality (PA)Trismus0.0000014Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.0000014Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip joint0.00006746Highly InformativeDirect
Phenotypic Abnormality (PA)Dilated cardiomyopathy0.0001904Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0009607Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the metatarsal bones0.004894Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.145Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0005167Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01922Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.0004163InformativeDirect
Worm Phenotype (WP)drug resistant0.0009293InformativeDirect
Worm Phenotype (WP)activity level variant0.04337InformativeInherited
Worm Phenotype (WP)embryonic arrest0.0002105Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.4594Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7864Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.8915Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.09402Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.3195Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.04495InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.1285InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.00001004Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome0.00002933Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0003157Moderately InformativeDirect
Biological processMitosis0.00000000001411InformativeDirect
Biological processMeiosis0.000006704InformativeDirect
Biological processDNA condensation0.00000000003122Highly InformativeDirect
Cellular componentCytoplasm0.000000000008606Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0.000007428Moderately InformativeDirect
Cellular componentChromosome0.0000403InformativeDirect
DiseaseAllergen0.00000001234Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationMyosin0.00000000001253Highly InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000001536Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0008695Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tropomyosin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Tropomyosin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]