SUPERFAMILY 1.75 HMM library and genome assignments server

Leucine zipper domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Leucine zipper domain [ 57959]
Families:   Leucine zipper domain [ 57960] (16)


Superfamily statistics
Genomes (473) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,720 16,585 97
Proteins 15,670 16,533 97


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.000066560Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0001440Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0025960.000000006657Least InformativeInherited
Biological Process (BP)cell differentiation0.0000020630.00000000000002458Moderately InformativeDirect
Biological Process (BP)immune system process0.000039760.00000001033Moderately InformativeDirect
Biological Process (BP)organ development0.14220.0007102Moderately InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00000017250.000002764InformativeDirect
Molecular Function (MF)binding0.0012560Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00000002390Moderately InformativeDirect
Molecular Function (MF)DNA binding0.00000000074310InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000006657 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000001465 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000001085 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000001433 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000092 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00003102 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001819 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.02166 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cell differentiation 0.00000000000002458 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000001033 Moderately Informative Direct
Biological Process (BP) organ development 0.0007102 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000000105 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000000009735 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.09549 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9338 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1061 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9906 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2044 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001489 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.6858 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.000002764 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.000000000000007347 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00000000002048 Informative Direct
Biological Process (BP) response to inorganic substance 0.0003788 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0006103 Informative Direct
Biological Process (BP) regulation of cytokine production 0.001319 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3637 Informative Inherited
Biological Process (BP) response to lipid 0.6531 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.08753 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.06844 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9322 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.4304 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.926 Informative Inherited
Biological Process (BP) single-organism behavior 0.1451 Informative Inherited
Biological Process (BP) regulation of immune response 0.1372 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.2144 Informative Inherited
Biological Process (BP) immune effector process 0.9373 Informative Inherited
Biological Process (BP) immune response 0.2429 Informative Inherited
Biological Process (BP) response to oxidative stress 0.3503 Informative Inherited
Biological Process (BP) leukocyte activation 0.01472 Informative Inherited
Biological Process (BP) cell cycle process 0.5599 Informative Inherited
Biological Process (BP) muscle structure development 0.8446 Informative Inherited
Biological Process (BP) muscle tissue development 0.3069 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) generation of neurons 0.1136 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2536 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.4016 Informative Inherited
Biological Process (BP) DNA metabolic process 0.1062 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.1893 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001599 Informative Inherited
Biological Process (BP) sexual reproduction 0.03945 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.007371 Informative Inherited
Biological Process (BP) hexose metabolic process 0.004463 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.33 Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000000002308 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.00000001693 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.0000002928 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0000005194 Highly Informative Direct
Biological Process (BP) mitosis 0.000003488 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.000006305 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000009259 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.000009432 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 0.00003778 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.00003884 Highly Informative Direct
Biological Process (BP) placenta development 0.0001089 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0002505 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.0002641 Highly Informative Direct
Biological Process (BP) aging 0.0004214 Highly Informative Direct
Biological Process (BP) B cell activation 0.0004827 Highly Informative Direct
Biological Process (BP) response to axon injury 0.0008664 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0009354 Highly Informative Direct
Biological Process (BP) response to alcohol 0.08392 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.07773 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.1097 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.001647 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.007953 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.7686 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.00111 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.2822 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.001454 Highly Informative Inherited
Biological Process (BP) DNA replication 0.05956 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.04648 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3959 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.1281 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3669 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.005351 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01618 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.8808 Highly Informative Inherited
Biological Process (BP) innate immune response 0.7936 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.08673 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.2114 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000000004904 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.000000004999 Highly Informative Direct
Molecular Function (MF) kinase binding 0.01227 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.01063 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7105 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02152 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.0000000000000232 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002565Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0006869Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.03209Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.07032Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.07305Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.006994InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.2033InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.3034InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.5228InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.9888InformativeInherited
Mammalian Phenotype (MP)hyperkeratosis0.005168Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.2124Least InformativeInherited
Worm Phenotype (WP)RNA expression variant0.01942InformativeInherited
Worm Phenotype (WP)mRNA expression variant0.0008196Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.02436Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.005865Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of larval stage0.0005115InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0003113Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.1635Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2128Least InformativeInherited
Fly Anatomy (FA)adult0.3292Least InformativeInherited
Fly Anatomy (FA)organ system0.4577Least InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.273Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.3867Moderately InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.09821InformativeInherited
Fly Anatomy (FA)circulatory system0.1034InformativeInherited
Fly Anatomy (FA)adult heart0.0002581Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.02021Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.01852Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1865Least InformativeInherited
Xenopus ANatomical entity (XAN)intestine0.00006606Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1293Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.4486Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.02421InformativeInherited
Plant ANatomical entity (PAN)primary root0.0007648Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nasal preparations0.000000000007778Moderately InformativeDirect
Drugbank ATC_code (DB)pseudoephedrine0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.00000000000001855Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0000004491Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseTumor suppressor0.0008998Moderately InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.000000000555Moderately InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leucine zipper domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Leucine zipper domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]