SUPERFAMILY 1.75 HMM library and genome assignments server

Triple coiled coil domain of C-type lectins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Triple coiled coil domain of C-type lectins [ 57944]
Families:   Triple coiled coil domain of C-type lectins [ 57945] (3)


Superfamily statistics
Genomes (62) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 196 252 16
Proteins 196 252 16


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.000000002828 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000001784 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.07594 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00000000000004447 Moderately Informative Direct
Biological Process (BP) organ development 0.0002167 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.4513 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001704 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.09227 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.002443 Moderately Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.000000316 Informative Direct
Biological Process (BP) tube development 0.006622 Informative Inherited
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) ossification 0 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 0.00000000000001264 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.00001752 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0008904 Highly Informative Direct
Molecular Function (MF) binding 0.000003607 Least Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001369 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000000002262 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.00002785 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00006191 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.001875 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000000007823 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000000001768 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) nucleolar part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.006551Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.01019Moderately InformativeInherited
Disease Ontology (DO)obstructive lung disease0.4621Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis0.00000002304InformativeDirect
Disease Ontology (DO)chronic obstructive pulmonary disease0.00008923InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.00009973InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.000424InformativeDirect
Disease Ontology (DO)asthma0.000444InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0000004079Highly InformativeDirect
Disease Ontology (DO)cystic fibrosis0.00001851Highly InformativeDirect
Disease Ontology (DO)tuberculosis0.00002697Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.06291Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07758Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.0991Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.002396Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.004829Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01336Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.01515Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.000419InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0.001194InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInnate immunity0InformativeDirect
Biological processComplement pathway0.00000001115Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0.000000000000003815InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.000000001441Least InformativeDirect
DomainCoiled coil0.0000000001511Moderately InformativeDirect
DomainCollagen0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.0001491Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationS-nitrosylation0.000000004068InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Triple coiled coil domain of C-type lectins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Triple coiled coil domain of C-type lectins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]