SUPERFAMILY 1.75 HMM library and genome assignments server

Blood coagulation inhibitor (disintegrin) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Blood coagulation inhibitor (disintegrin) [ 57551]
Superfamily:   Blood coagulation inhibitor (disintegrin) [ 57552]
Families:   Blood coagulation inhibitor (disintegrin) [ 57553] (6)


Superfamily statistics
Genomes (297) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,584 3,448 13
Proteins 2,464 3,353 13


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological adhesion0.00000090070.000000000000007248InformativeDirect
Biological Process (BP)cell adhesion0.00000069530.000000000000003707Highly InformativeDirect
Molecular Function (MF)binding0.003140.0007379Least InformativeInherited
Molecular Function (MF)protein complex binding0.00017320.00000001344InformativeDirect
Molecular Function (MF)receptor binding0.0011870.00000001398InformativeInherited
Molecular Function (MF)cell adhesion molecule binding0.000000040470Highly InformativeDirect
Cellular Component (CC)cell surface0.0000031620InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00001341 Least Informative Direct
Biological Process (BP) developmental process 0.4383 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1067 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.004273 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5796 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multi-organism process 0.0000000002446 Moderately Informative Direct
Biological Process (BP) reproductive process 0.00000001213 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.5273 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5707 Moderately Informative Inherited
Biological Process (BP) organ development 0.8739 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02373 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4442 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.4434 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05672 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5219 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.55 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01726 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6815 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6973 Moderately Informative Inherited
Biological Process (BP) tissue development 0.211 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2006 Moderately Informative Inherited
Biological Process (BP) biological adhesion 0.000000000000007248 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) sexual reproduction 0.00000000000001071 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000002632 Informative Direct
Biological Process (BP) cardiovascular system development 0.0001216 Informative Direct
Biological Process (BP) muscle structure development 0.008027 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.006316 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.003435 Informative Inherited
Biological Process (BP) gland development 0.01882 Informative Inherited
Biological Process (BP) single-organism behavior 0.003842 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.06812 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.079 Informative Inherited
Biological Process (BP) regulation of cell development 0.1562 Informative Inherited
Biological Process (BP) regulation of growth 0.00378 Informative Inherited
Biological Process (BP) localization of cell 0.005797 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.00539 Informative Inherited
Biological Process (BP) locomotion 0.08946 Informative Inherited
Biological Process (BP) cellular component movement 0.09725 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00223 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8733 Informative Inherited
Biological Process (BP) organ morphogenesis 0.0809 Informative Inherited
Biological Process (BP) epithelium development 0.4314 Informative Inherited
Biological Process (BP) cell adhesion 0.000000000000003707 Highly Informative Direct
Biological Process (BP) fertilization 0.00000000001069 Highly Informative Direct
Biological Process (BP) cell recognition 0.0000000002949 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000001318 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.000004277 Highly Informative Direct
Biological Process (BP) adult behavior 0.000005672 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.0000391 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00008522 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0001544 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0004528 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.001429 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.02601 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.07307 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002185 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001789 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001765 Highly Informative Inherited
Biological Process (BP) germ cell development 0.4184 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5669 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.003649 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.00662 Highly Informative Inherited
Molecular Function (MF) binding 0.0007379 Least Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) cation binding 0.00015 Moderately Informative Direct
Molecular Function (MF) protein complex binding 0.00000001344 Informative Direct
Molecular Function (MF) receptor binding 0.00000001398 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.000000004885 Informative Direct
Molecular Function (MF) enzyme binding 0.03011 Informative Inherited
Molecular Function (MF) cell adhesion molecule binding 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00005752 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.000000589 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane region 0.1258 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.2101 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01327 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.02129 Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.00000001031 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.009539Least InformativeInherited
Disease Ontology (DO)artery disease0.001429Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.00009064InformativeDirect
Disease Ontology (DO)breast carcinoma0.000242InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.377Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05723Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.2298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2665Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.08974InformativeInherited
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.000001083Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.000001281Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.000002212Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.00006234Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0002368Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart and great vessel attachment0.00844Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.1892Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.2162Least InformativeInherited
Xenopus DEvelopment stage (XDE)late tailbud stage0.0007707InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis4.711e-16Moderately InformativeDirect
Biological processDifferentiation0.00000004533Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processAngiogenesis0.000000000006185InformativeDirect
Biological processNotch signaling pathway0.00000000000007372Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.0006419Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1345Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0004018Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.000000007879Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001762 SSF57552 Protein matches
Abstract

Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion [PubMed15578957, PubMed15974889]. Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. Disintegrins act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and collagen [PubMed12050803]. The role of disintegrin in preventing blood coagulation renders it of medical interest, particularly with regard to its use as an anti-coagulant [PubMed16918409].

Disintegrins from different snake species have been characterised: albolabrin, applagin, barbourin, batroxostatin, bitistatin, obtustatin [PubMed12742023], schistatin [PubMed16101289], echistatin [PubMed15535803], elegantin, eristicophin, flavoridin [PubMed14499613], halysin, kistrin, tergeminin, salmosin [PubMed14661951] and triflavin.

Disintegrin-like proteins are found in various species ranging from slime mold to humans. Some other proteins known to contain a disintegrin domain are:

  • Some snake venom zinc metalloproteinases [PubMed15962120] consist of an N-terminal catalytic domain fused to a disintegrin domain. Such is the case for trimerelysin I (HR1B), atrolysin-e (Ht-e) and trigramin. It has been suggested that these proteinases are able to cleave themselves from the disintegrin domains and that the latter may arise from such a post-translational processing.
  • The beta-subunit of guinea pig sperm surface protein PH30 [PubMed1552944]. PH30 is a protein involved in sperm-egg fusion. The beta subunit contains a disintegrin at the N-terminal extremity.
  • Mammalian epididymial apical protein 1 (EAP I) [PubMed1417724]. EAP I is associated with the sperm membrane and may play a role in sperm maturation. Structurally, EAP I consists of an N-terminal domain, followed by a zinc metalloproteinase domain, a disintegrin domain, and a large C-terminal domain that contains a transmembrane region.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Blood coagulation inhibitor (disintegrin) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Blood coagulation inhibitor (disintegrin) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]