SUPERFAMILY 1.75 HMM library and genome assignments server


omega toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   omega toxin-like [ 57059] (5)
Families:   Conotoxin [ 57060]
  Spider toxins [ 57072] (25)
  Insect toxins [ 69930] (2)
  Albumin 1 [ 90134] (2)
  Vhv1.1, polydnaviral gene product [ 118237]


Superfamily statistics
Genomes (19) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 38 664 52
Proteins 38 652 52


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multi-organism process1.248e-122.711e-12Moderately InformativeDirect
Biological Process (BP)pathogenesis00Highly InformativeDirect
Molecular Function (MF)channel regulator activity00Highly InformativeDirect
Cellular Component (CC)extracellular region04.667e-15Moderately InformativeDirect
Cellular Component (CC)extracellular space5.129e-087.45e-08InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multi-organism process 2.711e-12 Moderately Informative Direct
Biological Process (BP) pathogenesis 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region 4.667e-15 Moderately Informative Direct
Cellular Component (CC) extracellular space 7.45e-08 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainKnottin0Highly InformativeDirect
Molecular functionLectin1.632e-05InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationIon channel impairing toxin0Highly InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationStorage protein5.037e-13Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues8.364e-08Moderately InformativeDirect
Post-translational modificationAmidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a omega toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the omega toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]