SUPERFAMILY 1.75 HMM library and genome assignments server


SRCR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRCR-like [ 56486] (2)
Superfamily:   SRCR-like [ 56487] (2)
Families:   Scavenger receptor cysteine-rich (SRCR) domain [ 56488]
  Hepsin, N-terminal domain [ 103355]


Superfamily statistics
Genomes (147) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 10,728 10,776 3
Proteins 3,699 3,568 3


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 6.756e-10 Least Informative Direct
Biological Process (BP) localization 2.017e-08 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.038e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.002555 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1717 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.5142 Least Informative Inherited
Biological Process (BP) developmental process 0.02407 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.08566 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02409 Least Informative Inherited
Biological Process (BP) regulation of developmental process 1.431e-09 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 5.39e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.116e-07 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 8.133e-07 Moderately Informative Direct
Biological Process (BP) system process 8.995e-07 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001592 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0002312 Moderately Informative Direct
Biological Process (BP) organ development 0.0006333 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0006996 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.3246 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.003453 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.0166 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.04254 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.008488 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03237 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01418 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2587 Moderately Informative Inherited
Biological Process (BP) tissue development 0.064 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1109 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03231 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.009429 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4296 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.3063 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3896 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.09876 Moderately Informative Inherited
Biological Process (BP) cellular component disassembly 5.974e-12 Informative Direct
Biological Process (BP) metal ion transport 1.053e-11 Informative Direct
Biological Process (BP) proteolysis 1.06e-11 Informative Direct
Biological Process (BP) transmembrane transport 6.449e-11 Informative Direct
Biological Process (BP) regulation of reproductive process 1.622e-08 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 3.187e-08 Informative Direct
Biological Process (BP) embryonic organ development 5.195e-08 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 5.694e-08 Informative Direct
Biological Process (BP) cell proliferation 1.566e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 4.152e-06 Informative Direct
Biological Process (BP) positive regulation of developmental process 3.516e-05 Informative Direct
Biological Process (BP) regulation of growth 5.874e-05 Informative Direct
Biological Process (BP) embryonic morphogenesis 8.351e-05 Informative Direct
Biological Process (BP) single-organism behavior 9.02e-05 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001278 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0001458 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0002114 Informative Direct
Biological Process (BP) sensory organ development 0.0002729 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2519 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.002403 Informative Inherited
Biological Process (BP) response to external stimulus 0.06998 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3168 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.4325 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01099 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.02046 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.03848 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01574 Informative Inherited
Biological Process (BP) secretion 0.006173 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4518 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.04603 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.009972 Informative Inherited
Biological Process (BP) cardiovascular system development 0.005544 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04131 Informative Inherited
Biological Process (BP) locomotion 0.0106 Informative Inherited
Biological Process (BP) cellular component movement 0.01204 Informative Inherited
Biological Process (BP) localization of cell 0.09305 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.006384 Informative Inherited
Biological Process (BP) ion transmembrane transport 0 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 7.835e-15 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 6.802e-14 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 9.858e-14 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 3.005e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.423e-11 Highly Informative Direct
Biological Process (BP) stem cell development 4.321e-11 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1.603e-10 Highly Informative Direct
Biological Process (BP) inner ear development 3.391e-10 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 6.037e-10 Highly Informative Direct
Biological Process (BP) response to hypoxia 3.622e-09 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 1.7e-08 Highly Informative Direct
Biological Process (BP) learning or memory 2.652e-08 Highly Informative Direct
Biological Process (BP) angiogenesis 8.918e-08 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.418e-07 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 4.328e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 4.938e-07 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 3.096e-06 Highly Informative Direct
Biological Process (BP) exocytosis 5.752e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 6.253e-06 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0002633 Highly Informative Direct
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 0.0005543 Highly Informative Direct
Biological Process (BP) sensory perception 0.005741 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.02521 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.04246 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 5.549e-05 Least Informative Direct
Molecular Function (MF) binding 0.7256 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0005783 Moderately Informative Direct
Molecular Function (MF) protein binding 0.1797 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.00105 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 1.909e-09 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.915e-08 Informative Direct
Molecular Function (MF) receptor activity 0.0003192 Informative Direct
Molecular Function (MF) enzyme binding 0.002054 Informative Inherited
Molecular Function (MF) serine-type peptidase activity 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.935e-10 Highly Informative Direct
Molecular Function (MF) ion channel activity 3.845e-09 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.003101 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.742 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.011e-10 Moderately Informative Direct
Cellular Component (CC) extracellular region 9.362e-10 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 3.875e-06 Moderately Informative Direct
Cellular Component (CC) organelle membrane 4.378e-06 Moderately Informative Direct
Cellular Component (CC) organelle envelope 2.509e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0003574 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.2454 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.01124 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1713 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) neuron part 3.129e-15 Informative Direct
Cellular Component (CC) extracellular matrix 1.494e-14 Informative Direct
Cellular Component (CC) integral to membrane 2.426e-12 Informative Direct
Cellular Component (CC) nuclear envelope 6.286e-11 Informative Direct
Cellular Component (CC) cell junction 2.661e-06 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 1.548e-05 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 3.008e-05 Informative Direct
Cellular Component (CC) secretory granule 0.002733 Informative Inherited
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 2.595e-12 Highly Informative Direct
Cellular Component (CC) cell body 1.051e-11 Highly Informative Direct
Cellular Component (CC) cell-cell junction 7.933e-08 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 9.464e-07 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1.678e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 2.26e-05 Highly Informative Direct
Cellular Component (CC) vesicle membrane 3.317e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases9.514e-05Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.000234Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)7.843e-14Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Enteropeptidase6.957e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0001068Moderately InformativeDirect
Biological processInnate immunity2.955e-15InformativeDirect
Biological processCell adhesion8.449e-12InformativeDirect
Biological processInflammatory response8.366e-10InformativeDirect
Biological processAcute phase3.308e-14Highly InformativeDirect
Cellular componentMembrane3.512e-08Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000221Moderately InformativeDirect
Cellular componentExtracellular matrix2.885e-10InformativeDirect
Cellular componentChromosome3.201e-09InformativeDirect
Cellular componentBasement membrane0.0002639Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat1.477e-12Least InformativeDirect
DomainTransmembrane0.002403Least InformativeInherited
DomainSignal-anchor0Moderately InformativeDirect
DomainKringle0Highly InformativeDirect
DomainCollagen1.061e-09Highly InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHydrolase1.075e-07Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor4.881e-11Moderately InformativeDirect
Post-translational modificationRepressor4.633e-07Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00012Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationChromatin regulator5.215e-12InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRCR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the SRCR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]