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ADC synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ADC synthase [ 56321]
Superfamily:   ADC synthase [ 56322]
Families:   ADC synthase [ 56323] (5)

Superfamily statistics
Genomes (1,991) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,187 18,762 8
Proteins 5,172 18,744 8

 Functional annotation
General category Metabolism
Detailed category Other enzymes

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process1.78e-058.059e-07Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00062284.277e-07Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.0083720.008375Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.015220.014Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.010750.01042Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00081351.643e-07Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.00095127.979e-05Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00016110.0003148Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00038475.463e-06Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00033575.203e-07Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.00098620.0001303Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.0019040.0001122Moderately InformativeInherited
Biological Process (BP)amine biosynthetic process0.00028731.354e-06InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process1.122e-061.776e-10Highly InformativeDirect
Molecular Function (MF)transferase activity0.58750.6148Least InformativeInherited
Molecular Function (MF)lyase activity0.00013092.624e-05Moderately InformativeDirect
Molecular Function (MF)isomerase activity1.644e-051.867e-07Moderately InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity1.612e-091.222e-11InformativeDirect
Molecular Function (MF)transaminase activity4.423e-066.003e-11Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity3.48e-120Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity5.033e-121.562e-15Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 8.059e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 4.277e-07 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.008375 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.014 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01042 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1.643e-07 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 7.979e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0003148 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 5.463e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 5.203e-07 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001122 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0001303 Moderately Informative Direct
Biological Process (BP) amine biosynthetic process 1.354e-06 Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 1.776e-10 Highly Informative Direct
Molecular Function (MF) transferase activity 0.6148 Least Informative Inherited
Molecular Function (MF) lyase activity 2.624e-05 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1.867e-07 Moderately Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1.222e-11 Informative Direct
Molecular Function (MF) transaminase activity 6.003e-11 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 1.562e-15 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0005844Least InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups1.323e-07InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.0007488Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)2.503e-10InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups1.275e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis3.394e-07Highly InformativeDirect
DomainGlutamine amidotransferase1.077e-06Highly InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationIsomerase4.726e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.908Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)tryptophan metabolism0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis8.351e-06InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism1.627e-05InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0.004068InformativeInherited
UniPathway (UP)pteridine biosynthesis1InformativeInherited
UniPathway (UP)L-tryptophan biosynthesis0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate biosynthesis8.668e-13Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis8.013e-05Highly InformativeDirect
UniPathway (UP)siderophore biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005801 SSF56322 Protein matches
Abstract This entry represents the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. Anthranilate synthase catalyses the reaction: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate. The enzyme is a tetramer comprising 2 I and 2 II components: this entry is restricted to component I that catalyses the formation of anthranilate using ammonia rather than glutamine, while component II provides glutamine amidotransferase activity .

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADC synthase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the ADC synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.