SUPERFAMILY 1.75 HMM library and genome assignments server


Bactericidal permeability-increasing protein, BPI superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Aha1/BPI domain-like [ 55393] (2)
Superfamily:   Bactericidal permeability-increasing protein, BPI [ 55394]
Families:   Bactericidal permeability-increasing protein, BPI [ 55395]


Superfamily statistics
Genomes (322) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,262 2,336 4
Proteins 1,428 1,467 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.043060.003113Least InformativeInherited
Biological Process (BP)single-organism cellular process0.18181Least InformativeInherited
Biological Process (BP)cellular component movement1.904e-054.983e-06InformativeDirect
Biological Process (BP)locomotion3.412e-055.233e-05InformativeDirect
Biological Process (BP)localization of cell4.815e-064.476e-05InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.003113 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3301 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.2177 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3893 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3628 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multi-organism process 0.02397 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07397 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.001059 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.003173 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.007761 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001576 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 1.541e-06 Informative Direct
Biological Process (BP) vitamin metabolic process 7.614e-09 Informative Direct
Biological Process (BP) cellular component movement 4.983e-06 Informative Direct
Biological Process (BP) defense response 8.122e-05 Informative Direct
Biological Process (BP) immune response 0.0003491 Informative Direct
Biological Process (BP) locomotion 5.233e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0002205 Informative Direct
Biological Process (BP) localization of cell 4.476e-05 Informative Direct
Biological Process (BP) response to other organism 0.001052 Informative Inherited
Biological Process (BP) response to wounding 0.001555 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.007866 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0003013 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0006172 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) lipid binding 2.333e-11 Informative Direct
Cellular Component (CC) extracellular region 7.84e-09 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.0001524 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.001756Least InformativeInherited
Biological processLipid metabolism0.00401Moderately InformativeInherited
Biological processLipid transport0InformativeDirect
Biological processSteroid metabolism4.846e-10InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bactericidal permeability-increasing protein, BPI domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Bactericidal permeability-increasing protein, BPI superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · UniProtKB KeyWords (KW) · Internal database links ]