SUPERFAMILY 1.75 HMM library and genome assignments server

FAD-linked oxidases, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   FAD-linked oxidases, C-terminal domain [ 55103] (4)
Families:   Vanillyl-alcohol oxidase-like [ 55104] (2)
  D-lactate dehydrogenase [ 55109]
  Cholesterol oxidase [ 64284]
  Cytokinin dehydrogenase 1 [ 110990]


Superfamily statistics
Genomes (2,312) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,593 33,662 15
Proteins 8,501 33,498 15


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0004392 Least Informative Direct
Biological Process (BP) biosynthetic process 0.3358 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.002113 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4353 Moderately Informative Inherited
Biological Process (BP) regulation of hormone levels 0.000004445 Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0000007118 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.9645 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000242 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.00000000000003169 Informative Direct
Molecular Function (MF) cofactor binding 0.0000000000001339 Informative Direct
Molecular Function (MF) nucleotide binding 0.00000001562 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0001056 Informative Direct
Cellular Component (CC) cytoplasmic part 0.0002236 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.01325 Least Informative Inherited
Cellular Component (CC) microbody 0.0000004056 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.000000000000002328Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.03305Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.000209Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.00002173Moderately InformativeDirect
Biological processLipid biosynthesis0.000001704InformativeDirect
Cellular componentMitochondrion0.0000000002345Moderately InformativeDirect
Cellular componentSecreted0.00000001919Moderately InformativeDirect
Cellular componentPeroxisome0.000000000000002231InformativeDirect
DomainTransit peptide0.0000000000001255Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationGlycoprotein0.00001503Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.00000003698Least InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.000000003001Moderately InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)glycerolipid biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-linked oxidases, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the FAD-linked oxidases, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]