SUPERFAMILY 1.75 HMM library and genome assignments server


GMP synthetase C-terminal dimerisation domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Alpha-lytic protease prodomain-like [ 54805] (10)
Superfamily:   GMP synthetase C-terminal dimerisation domain [ 54810]
Families:   GMP synthetase C-terminal dimerisation domain [ 54811]


Superfamily statistics
Genomes (2,141) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,429 6,696 1
Proteins 2,259 6,476 1


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.00846 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.004587 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.006543 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.004494 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.009767 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.003705 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.551e-10 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 2.397e-07 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 5.879e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 1.024e-05 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 2.051e-05 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 2.185e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.58e-05 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.962e-05 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 5.17e-05 Moderately Informative Direct
Biological Process (BP) ribonucleoside metabolic process 8.482e-08 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 6.406e-07 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 2.967e-06 Informative Direct
Biological Process (BP) purine nucleoside metabolic process 0.4177 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.1759 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.009106 Informative Inherited
Biological Process (BP) guanosine-containing compound metabolic process 5.105e-10 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 1.74e-07 Highly Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.724e-11 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect
UniPathway (UP)GMP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GMP synthetase C-terminal dimerisation domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the GMP synthetase C-terminal dimerisation domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]