SUPERFAMILY 1.75 HMM library and genome assignments server

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [ 54592]
Superfamily:   Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [ 54593] (10)
Families:   Glyoxalase I (lactoylglutathione lyase) [ 54594]
  Antibiotic resistance proteins [ 54598] (7)
  Methylmalonyl-CoA epimerase [ 64257]
  Hypothetical protein YecM (EC4020) [ 75396]
  Extradiol dioxygenases [ 54602] (4)
  Hypothetical protein BC1747 [ 110880]
  3-demethylubiquinone-9 3-methyltransferase [ 110883] (4)
  Hypothetical protein YycE [ 110888]
  Hypothetical protein At5g48480 [ 117876]
  BC1024-like [ 143129]


Superfamily statistics
Genomes (2,743) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 29,835 172,604 46
Proteins 27,384 154,850 43


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.72240.0001697Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.3163Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.28010.000000005806Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.11780.03399Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.004050.0000000000008024InformativeInherited
Biological Process (BP)peptide metabolic process0.0015060.001666InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.050490.7747InformativeInherited
Biological Process (BP)glutathione metabolic process0.00015450.00001008Highly InformativeDirect
Biological Process (BP)methylglyoxal metabolic process0.000039070Highly InformativeDirect
Molecular Function (MF)lyase activity0.0000060470.000000003332Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.0011790.006744Moderately InformativeInherited
Molecular Function (MF)racemase and epimerase activity0.00000044350.0000004169InformativeDirect
Molecular Function (MF)carbon-sulfur lyase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0001697 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.3163 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4554 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3876 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.000000005806 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0002255 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00003473 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.03399 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.03219 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.0000000000008024 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0004618 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.04352 Informative Inherited
Biological Process (BP) peptide metabolic process 0.001666 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.7747 Informative Inherited
Biological Process (BP) lactate metabolic process 0.000001456 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00001008 Highly Informative Direct
Biological Process (BP) methylglyoxal metabolic process 0 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.00003151 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0.000001918 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.000000003332 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.006744 Moderately Informative Inherited
Molecular Function (MF) racemase and epimerase activity 0.0000004169 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0 Highly Informative Direct
Molecular Function (MF) carbon-sulfur lyase activity 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.000003428Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.2277Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.05007Moderately InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0InformativeDirect
Enzyme Commission (EC)Carbon-sulfur lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00002803Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.1559Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.3158Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.7031Moderately InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.0007641InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Carbon-sulfur lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPhenylalanine catabolism0Highly InformativeDirect
Biological processDetoxification0.000000003274Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionMagnesium0.000149Moderately InformativeDirect
Molecular functionNickel0.000000000004738InformativeDirect
Molecular functionCobalt0.00007758InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationLyase0.0000003132Moderately InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.0158Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.9014Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.00001016Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0002543InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0.01122InformativeInherited
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]