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  Home > SCOP hierarchy > Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily


Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [ 54592]
Superfamily:   Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [ 54593] (10)
Families:   Glyoxalase I (lactoylglutathione lyase) [ 54594]
  Antibiotic resistance proteins [ 54598] (7)
  Methylmalonyl-CoA epimerase [ 64257]
  Hypothetical protein YecM (EC4020) [ 75396]
  Extradiol dioxygenases [ 54602] (4)
  Hypothetical protein BC1747 [ 110880]
  3-demethylubiquinone-9 3-methyltransferase [ 110883] (4)
  Hypothetical protein YycE [ 110888]
  Hypothetical protein At5g48480 [ 117876]
  BC1024-like [ 143129]

 Superfamily statistics
Genomes (2,113) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 22,748 68,312 46
Proteins 20,875 63,200 43

 Functional annotation
General category Metabolism
Detailed category Redox

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.92030.2059Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.58015.493e-05Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.25635.15e-09Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.038390.6053InformativeInherited
Biological Process (BP)cellular amide metabolic process0.014250.0009057InformativeInherited
Biological Process (BP)glutathione metabolic process9.243e-052.877e-06Highly InformativeDirect
Molecular Function (MF)lyase activity1.432e-058.645e-07Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.00028210.0009818Moderately InformativeDirect
Molecular Function (MF)racemase and epimerase activity1.173e-081.972e-09InformativeDirect
Molecular Function (MF)carbon-sulfur lyase activity1.539e-140Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 5.493e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.2059 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3214 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2984 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 5.15e-09 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0004238 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 1.07e-05 Moderately Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0009057 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 5.803e-06 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0101 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.6053 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 8.774e-10 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 2.877e-06 Highly Informative Direct
Biological Process (BP) aromatic amino acid family catabolic process 6.051e-13 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 7.708e-05 Moderately Informative Direct
Molecular Function (MF) lyase activity 8.645e-07 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0009818 Moderately Informative Direct
Molecular Function (MF) racemase and epimerase activity 1.972e-09 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0 Highly Informative Direct
Molecular Function (MF) carbon-sulfur lyase activity 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases3.428e-06Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.2277Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.05007Moderately InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0InformativeDirect
Enzyme Commission (EC)Carbon-sulfur lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases9.345e-06Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.2496Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.4587Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.8441Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.003947InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Carbon-sulfur lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPhenylalanine catabolism0Highly InformativeDirect
Biological processTyrosine catabolism0Highly InformativeDirect
Biological processDetoxification2.5e-09Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionMagnesium8.974e-05Moderately InformativeDirect
Molecular functionNickel1.288e-09InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationLyase1.91e-07Moderately InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.005118Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.9152Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0001303Moderately InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0.007994InformativeInherited
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.