SUPERFAMILY 1.75 HMM library and genome assignments server

Chitinase insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FKBP-like [ 54533] (3)
Superfamily:   Chitinase insertion domain [ 54556]
Families:   Chitinase insertion domain [ 54557] (10)


Superfamily statistics
Genomes (775) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,396 7,757 39
Proteins 3,203 7,550 39


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.3887 Least Informative Inherited
Biological Process (BP) developmental process 0.006459 Least Informative Inherited
Biological Process (BP) localization 0.06441 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1847 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2049 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.002774 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.002505 Least Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000000009583 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000002563 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000005401 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.000000002574 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000006449 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000000008228 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000009944 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000000101 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000000145 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000001489 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000001591 Moderately Informative Direct
Biological Process (BP) organ development 0.0000009102 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000001173 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000002612 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000002814 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000004708 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000006866 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00002081 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0002755 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0008071 Moderately Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) regulation of kinase activity 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000000000000001938 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.000000000000003755 Informative Direct
Biological Process (BP) tube development 0.00000000000002119 Informative Direct
Biological Process (BP) protein transport 0.00000000000003788 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.0000000000001052 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0000000000001333 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000000000002131 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0000000000002146 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000002521 Informative Direct
Biological Process (BP) defense response 0.000000000002964 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000000000007501 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000002358 Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00000003634 Least Informative Direct
Molecular Function (MF) binding 0.2174 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) receptor binding 0.00005191 Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0000000000001721 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.7124 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.000000000000003095 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000000000005785 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)obstructive lung disease0.0003147Moderately InformativeDirect
Disease Ontology (DO)asthma0.0001178InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processFertilization0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000004Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000005215Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionLectin0.000000000000002286InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase4.449e-16Least InformativeDirect
Post-translational modificationDevelopmental protein0.000000000008182Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationAntimicrobial0.00000000000002605InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00001232Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Chitinase insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 14 hidden Markov models representing the Chitinase insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]