SUPERFAMILY 1.75 HMM library and genome assignments server

FKBP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FKBP-like [ 54533] (3)
Superfamily:   FKBP-like [ 54534] (3)
Families:   FKBP immunophilin/proline isomerase [ 54535] (16)
  GreA transcript cleavage factor, C-terminal domain [ 54549]
  3-mercaptopyruvate sulfurtransferase, C-terminal domain [ 102868]


Superfamily statistics
Genomes (3,240) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 26,607 120,408 48
Proteins 23,903 112,838 44


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.02630.1957Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00028210.8137Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.091890.6793Least InformativeInherited
Biological Process (BP)response to stimulus0.01170.01289Least InformativeInherited
Biological Process (BP)multicellular organismal process0.15830.2219Least InformativeInherited
Biological Process (BP)protein metabolic process0.0013720.000000000004511Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0031370.00000000000002793Least InformativeInherited
Biological Process (BP)single-organism cellular process0.18260.9093Least InformativeInherited
Biological Process (BP)regulation of biological quality0.13620.6973Moderately InformativeInherited
Biological Process (BP)regulation of localization0.013340.2512Moderately InformativeInherited
Biological Process (BP)immune system process0.00052680.09625Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0001773Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.12110.1421Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.020970.2676Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.26340.5537Moderately InformativeInherited
Biological Process (BP)ion transport0.0033770.0439Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000021760.1081Moderately InformativeInherited
Biological Process (BP)signal transduction0.045580.07673Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.027120.4378Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0000076440.5051Moderately InformativeInherited
Biological Process (BP)cellular localization0.0057620.0493Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0093460.1886Moderately InformativeInherited
Biological Process (BP)system process0.00010470.1032Moderately InformativeInherited
Biological Process (BP)muscle system process0.0000000002240.00000003909InformativeDirect
Biological Process (BP)cytoplasmic transport0.0000023510.00016InformativeDirect
Biological Process (BP)peptidyl-amino acid modification0.0000000000072280InformativeDirect
Biological Process (BP)metal ion transport0.000000082660.00000974InformativeDirect
Biological Process (BP)leukocyte activation0.000000018320.000002978InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process0.0000046160.0005744InformativeDirect
Biological Process (BP)cation homeostasis0.00000034480.00000652InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.00000032720.005078InformativeInherited
Biological Process (BP)response to organonitrogen compound0.017970.3451InformativeInherited
Biological Process (BP)response to cytokine stimulus0.0031610.01654InformativeInherited
Biological Process (BP)response to organic cyclic compound0.032010.1881InformativeInherited
Biological Process (BP)protein folding0.00028510Highly InformativeDirect
Biological Process (BP)calcium ion transport0.000000000095180.00000001051Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis0.0000000002240.0000000006238Highly InformativeDirect
Biological Process (BP)response to purine-containing compound0.0000000008250.0000009986Highly InformativeDirect
Biological Process (BP)peptidyl-proline modification00Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.000000012550.000004283Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00000011390.000167Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.000000027130.0008647Highly InformativeDirect
Biological Process (BP)response to alkaloid0.00000000026090.0000002925Highly InformativeDirect
Biological Process (BP)leukocyte proliferation0.00000000000030870.000000000004309Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis0.00000000029660.0000000001732Highly InformativeDirect
Molecular Function (MF)binding0.0075230.002921Least InformativeInherited
Molecular Function (MF)isomerase activity0.000000000017580Moderately InformativeDirect
Molecular Function (MF)drug binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.015330.008874Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.062070.1944Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.006530.2131Least InformativeInherited
Cellular Component (CC)membrane0.018010.3884Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.000000000001460.0000000002936Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0000015610.000003747Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.00086490.07537Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.0000000011170.00000000344InformativeDirect
Cellular Component (CC)sarcoplasmic reticulum0.0000033080.00000001133Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000000004511 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000000002793 Least Informative Direct
Biological Process (BP) localization 0.1957 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6793 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8137 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01289 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2219 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9093 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.0001773 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.6973 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2512 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0493 Moderately Informative Inherited
Biological Process (BP) immune system process 0.09625 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2212 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1304 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4161 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1421 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5537 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2676 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9342 Moderately Informative Inherited
Biological Process (BP) ion transport 0.0439 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4378 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1081 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.07673 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5051 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1886 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6982 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2199 Moderately Informative Inherited
Biological Process (BP) system process 0.1032 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) muscle system process 0.00000003909 Informative Direct
Biological Process (BP) cytoplasmic transport 0.00016 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) metal ion transport 0.00000974 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0001832 Informative Direct
Biological Process (BP) leukocyte activation 0.000002978 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0005744 Informative Direct
Biological Process (BP) cation homeostasis 0.00000652 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.005078 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.3451 Informative Inherited
Biological Process (BP) sexual reproduction 0.1658 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02183 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3435 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.3288 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.005267 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01769 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.08372 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.6152 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.01654 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1881 Informative Inherited
Biological Process (BP) generation of neurons 0.8622 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.09195 Informative Inherited
Biological Process (BP) regulation of cell development 0.1612 Informative Inherited
Biological Process (BP) regulation of ion transport 0.003794 Informative Inherited
Biological Process (BP) regulation of system process 0.1097 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00000001051 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0000000006238 Highly Informative Direct
Biological Process (BP) response to heat 0.0004265 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000009986 Highly Informative Direct
Biological Process (BP) peptidyl-proline modification 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000004283 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.000004812 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000167 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0008647 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.0000002925 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00001186 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.000000000004309 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000000001732 Highly Informative Direct
Biological Process (BP) DNA modification 0.0233 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.01581 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.002627 Highly Informative Inherited
Biological Process (BP) gene silencing 0.005338 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002024 Highly Informative Inherited
Molecular Function (MF) binding 0.002921 Least Informative Inherited
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0.00008119 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.008874 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1944 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2131 Least Informative Inherited
Cellular Component (CC) membrane 0.3884 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.8404 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0000000002936 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000003747 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.07537 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.0793 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.9691 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00000000344 Informative Direct
Cellular Component (CC) plastid 0.0001373 Informative Direct
Cellular Component (CC) neuron projection 0.02186 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.05185 Informative Inherited
Cellular Component (CC) chromosome 0.2743 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 0.00000001133 Highly Informative Direct
Cellular Component (CC) growth cone 0.000000008197 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.01774 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2065Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.006957InformativeInherited
Phenotypic Abnormality (PA)Kyphosis0.0004248Highly InformativeDirect
Phenotypic Abnormality (PA)Reduced bone mineral density0.0006166Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00006652Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0.2644Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0000000132Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000006993Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.0005109Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processRNA-mediated gene silencing0.00025Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentPeriplasm0InformativeDirect
Cellular componentCell outer membrane0.000423InformativeDirect
DomainSignal0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FKBP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 30 hidden Markov models representing the FKBP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]