SUPERFAMILY 1.75 HMM library and genome assignments server

FAD-linked reductases, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FAD-linked reductases, C-terminal domain [ 54372]
Superfamily:   FAD-linked reductases, C-terminal domain [ 54373] (7)
Families:   GMC oxidoreductases [ 54374] (5)
  PHBH-like [ 54378] (4)
  D-aminoacid oxidase-like [ 54384] (3)
  UDP-galactopyranose mutase [ 69670]
  L-aminoacid/polyamine oxidase [ 54394] (6)
  GDI-like [ 54399] (2)
  Electron transfer flavoprotein-ubiquinone oxidoreductase-like [ 142988]


Superfamily statistics
Genomes (2,796) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 27,321 96,614 74
Proteins 27,235 96,524 74


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000008113 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.534 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7677 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000295 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000004724 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0000001156 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.001795 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2202 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.6469 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.2382 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.6724 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.6731 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.6669 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7762 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1731 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.0000000000003004 Informative Direct
Biological Process (BP) regulation of hormone levels 0.000000002413 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000000000000336 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0005064 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000001639 Informative Direct
Biological Process (BP) secondary metabolic process 0.3048 Informative Inherited
Biological Process (BP) pigment metabolic process 0.002901 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0575 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1815 Informative Inherited
Biological Process (BP) chromosome organization 0.7077 Informative Inherited
Biological Process (BP) polyamine metabolic process 0.0000783 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.0000007164 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0000007173 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000000002654 Highly Informative Direct
Biological Process (BP) heme metabolic process 0.00003033 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0001718 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0008512 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.000002875 Highly Informative Direct
Biological Process (BP) histone modification 0.01741 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.2096 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.0919 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.009192 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001662 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.0000004622 Informative Direct
Molecular Function (MF) electron carrier activity 0.0000004434 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.46 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0.00007913 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.6008 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.00001018 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.00000002867 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.08334 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0.00006037 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.00913 Informative Inherited
Cellular Component (CC) organelle outer membrane 0.0005356 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.006288 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.01911Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.000005291Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.00001959Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000000007149InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.005472InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.2536InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.9537InformativeInherited
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.0000000000001719Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000009264Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.0004287Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.04523Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.00000004968InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.000009556InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.0000000000005727Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000000000008345Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00000000004487Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.002354Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.227Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.000000000003553Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processAromatic hydrocarbons catabolism0.0000000004635InformativeDirect
Biological processtRNA processing0.000000008033InformativeDirect
Biological processNitrogen fixation0.0004008InformativeDirect
Biological processGlycerol metabolism9.345e-16Highly InformativeDirect
Biological processHeme biosynthesis0.000000000000001398Highly InformativeDirect
Biological processAuxin biosynthesis0.00000000000003945Highly InformativeDirect
Biological processPorphyrin biosynthesis0.0000003383Highly InformativeDirect
Biological processHemolysis0.0009076Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane0.000000001027InformativeDirect
DomainTransit peptide0.000000000004641Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionUbiquinone0.000001002Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationMethyltransferase0.000000009574InformativeDirect
Post-translational modificationChromatin regulator0.00000189InformativeDirect
Post-translational modificationGTPase activation0.000003242InformativeDirect
Post-translational modificationToxin0.000006538InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAcetylation0.0005008Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.0008258Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.00000000000446Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0.04291Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism0.04357Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.2158Moderately InformativeInherited
UniPathway (UP)energy metabolism0.6006Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)choline metabolism0InformativeDirect
UniPathway (UP)polyol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.0000000000006087InformativeDirect
UniPathway (UP)plant hormone metabolism0.00000005187InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0.0001433InformativeDirect
UniPathway (UP)heterocycle biosynthesis0.02034InformativeInherited
UniPathway (UP)pigment biosynthesis0.06822InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)auxin metabolism0.0000000000008152Highly InformativeDirect
UniPathway (UP)opine metabolism0.00000004284Highly InformativeDirect
UniPathway (UP)sarcosine degradation0.0000002296Highly InformativeDirect
UniPathway (UP)LPS O-antigen biosynthesis0.0001467Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis0.0006913Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-linked reductases, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 30 hidden Markov models representing the FAD-linked reductases, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]