SUPERFAMILY 1.75 HMM library and genome assignments server


FAD-linked reductases, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FAD-linked reductases, C-terminal domain [ 54372]
Superfamily:   FAD-linked reductases, C-terminal domain [ 54373] (7)
Families:   GMC oxidoreductases [ 54374] (5)
  PHBH-like [ 54378] (4)
  D-aminoacid oxidase-like [ 54384] (3)
  UDP-galactopyranose mutase [ 69670]
  L-aminoacid/polyamine oxidase [ 54394] (6)
  GDI-like [ 54399] (2)
  Electron transfer flavoprotein-ubiquinone oxidoreductase-like [ 142988]


Superfamily statistics
Genomes (2,142) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 22,843 45,657 74
Proteins 22,801 45,613 74


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 1.516e-13 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.03953 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1.192e-07 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 1.059e-06 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 1.877e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 2.556e-06 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 1.284e-05 Moderately Informative Direct
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6993 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02856 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.002917 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.003728 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01531 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01987 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.04394 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 2.539e-09 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 5.102e-09 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 3.254e-05 Informative Direct
Biological Process (BP) pigment metabolic process 0.0001492 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) chromosome organization 0.02318 Informative Inherited
Biological Process (BP) polyamine metabolic process 0 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 4.153e-10 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 3.634e-08 Highly Informative Direct
Biological Process (BP) heme metabolic process 3.004e-07 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 6.847e-06 Highly Informative Direct
Biological Process (BP) histone modification 3.319e-05 Highly Informative Direct
Biological Process (BP) diol metabolic process 0.0002374 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0006598 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 5.856e-05 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.3504 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.5086 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 1.496e-09 Informative Direct
Molecular Function (MF) nucleotide binding 2.336e-08 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0001937 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.06069 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1692 Least Informative Inherited
Cellular Component (CC) membrane 0.6594 Least Informative Inherited
Cellular Component (CC) mitochondrial part 3.129e-15 Moderately Informative Direct
Cellular Component (CC) organelle envelope 1.03e-12 Moderately Informative Direct
Cellular Component (CC) organelle membrane 5.324e-07 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) microbody 7.091e-07 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.001812 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.01911Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors5.291e-06Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases1.959e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation7.149e-10InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.005472InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.2536InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.9537InformativeInherited
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor2.558e-15Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen1.719e-13Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor9.264e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.001814Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.02597Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors5.47e-06InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen2.76e-13Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen3.056e-10Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.001873Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.2696Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.11e-12Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processAromatic hydrocarbons catabolism2.921e-10InformativeDirect
Biological processtRNA processing2.38e-09InformativeDirect
Biological processNitrogen fixation0.0003919InformativeDirect
Biological processGlycerol metabolism4.622e-16Highly InformativeDirect
Biological processHeme biosynthesis2.729e-15Highly InformativeDirect
Biological processAuxin biosynthesis3.329e-14Highly InformativeDirect
Biological processPorphyrin biosynthesis4.472e-06Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane2.215e-10InformativeDirect
DomainTransit peptide4.337e-11Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionFlavoprotein0InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0005783InformativeDirect
Molecular functionUbiquinone2.056e-05Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationMethyltransferase4.05e-08InformativeDirect
Post-translational modificationToxin2.472e-06InformativeDirect
Post-translational modificationGTPase activation2.848e-06InformativeDirect
Post-translational modificationChromatin regulator6.122e-06InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAcetylation0.0004964Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.0005006Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism2.342e-11Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.337Moderately InformativeInherited
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)alcohol degradation1.767e-15InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis4.188e-13InformativeDirect
UniPathway (UP)hormone metabolism2.553e-07InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0.0008215InformativeDirect
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)alanine metabolism0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)auxin metabolism6.777e-13Highly InformativeDirect
UniPathway (UP)opine metabolism3.877e-08Highly InformativeDirect
UniPathway (UP)sarcosine degradation2.226e-07Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-linked reductases, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 30 hidden Markov models representing the FAD-linked reductases, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]