SUPERFAMILY 1.75 HMM library and genome assignments server

Interleukin 8-like chemokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   IL8-like [ 54116] (2)
Superfamily:   Interleukin 8-like chemokines [ 54117]
Families:   Interleukin 8-like chemokines [ 54118] (24)


Superfamily statistics
Genomes (65) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,033 2,955 51
Proteins 2,029 2,935 51


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000028220.0008207Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.51011Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0028490.02683Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.000053350.0974Least InformativeInherited
Biological Process (BP)protein metabolic process0.0011010.2569Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.020231Least InformativeInherited
Biological Process (BP)developmental process0.000000024760.01908Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)ion transport0.00000003410.00000001157Moderately InformativeDirect
Biological Process (BP)signal transduction0.00000029980.0000000009119Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0000024770.00009689Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000019270.00001711Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000048590.000587Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0000000000000032610Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00052380.0005772Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.00021930.00004016Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus00Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000000000021450.000000000001869Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.000021850.00000124Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000000015860.000000005546Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.00073420.00004318Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.60681Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.97851Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.24310.8635Moderately InformativeInherited
Biological Process (BP)cellular localization0.0084020.04168Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.080910.00008299Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.054931Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.045980.6994Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.000042730.005948Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.00000000002047Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00094210.6087Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.000000085210.001331Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)nervous system development0.00018650.01319Moderately InformativeInherited
Biological Process (BP)organelle organization0.51770.9533Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.000091080.009876Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0010560.006894Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.000330.00000006277InformativeDirect
Biological Process (BP)positive regulation of immune system process0.000000083360.00000000000009575InformativeDirect
Biological Process (BP)cellular component movement00InformativeDirect
Biological Process (BP)defense response0.000000022280.00000000000002119InformativeDirect
Biological Process (BP)immune response0.000015920.0000001297InformativeDirect
Biological Process (BP)cytoskeleton organization0.0000000000014140.00000000008651InformativeDirect
Biological Process (BP)response to wounding00InformativeDirect
Biological Process (BP)negative regulation of biosynthetic process0.00000020270.0003218InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.000037130.0003099InformativeDirect
Biological Process (BP)positive regulation of gene expression0.0000000059420.00002187InformativeDirect
Biological Process (BP)negative regulation of gene expression0.000011070.0004941InformativeDirect
Biological Process (BP)vesicle-mediated transport0.0000014130.00001196InformativeDirect
Biological Process (BP)phosphorylation0.0000000009450.0000001352InformativeDirect
Biological Process (BP)cytoplasmic transport0.000000000000030450.0000000000003954InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.000000003920.000000001733InformativeDirect
Biological Process (BP)metal ion transport00InformativeDirect
Biological Process (BP)regulation of defense response0.00091350.0004732InformativeDirect
Biological Process (BP)regulation of response to external stimulus00InformativeDirect
Biological Process (BP)secretion by cell0.0000000000011480.000000000002232InformativeDirect
Biological Process (BP)response to lipid0.00053140.0000008492InformativeDirect
Biological Process (BP)response to cytokine stimulus0.0000003170.000000003822InformativeDirect
Biological Process (BP)locomotion00InformativeDirect
Biological Process (BP)regulation of locomotion00InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0000092030.00000001909InformativeDirect
Biological Process (BP)regulation of ion transport0.0000000034110.0000000002892InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.0000018550.000004177InformativeDirect
Biological Process (BP)positive regulation of transport0.0000000000040030InformativeDirect
Biological Process (BP)negative regulation of developmental process00.00000000001324InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000020380.00002391InformativeDirect
Biological Process (BP)regulation of cellular component movement00InformativeDirect
Biological Process (BP)localization of cell00InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)cellular chemical homeostasis00.0000000002079InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process00InformativeDirect
Biological Process (BP)regulation of cell development10.9575InformativeInherited
Biological Process (BP)regulation of secretion0.0011420.004115InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.16430.1857InformativeInherited
Biological Process (BP)regulation of protein localization0.60880.4964InformativeInherited
Biological Process (BP)response to organic cyclic compound0.015430.07184InformativeInherited
Biological Process (BP)response to hormone stimulus11InformativeInherited
Biological Process (BP)regulation of intracellular transport0.56670.1647InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.30290.532InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.000050430.03761InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.64711InformativeInherited
Biological Process (BP)response to bacterium0.018540.05665InformativeInherited
Biological Process (BP)regulation of system process0.071090.1052InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.072720.5493InformativeInherited
Biological Process (BP)intracellular signal transduction0.60570.7377InformativeInherited
Biological Process (BP)regulation of body fluid levels0.0035820.0008749InformativeInherited
Biological Process (BP)cell cycle process0.36171InformativeInherited
Biological Process (BP)immune effector process0.12760.1416InformativeInherited
Biological Process (BP)leukocyte activation0.0014070.04948InformativeInherited
Biological Process (BP)cardiovascular system development0.37850.2963InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.060790.09588InformativeInherited
Biological Process (BP)MAPK cascade00Highly InformativeDirect
Biological Process (BP)ossification0.0000000000000032610.000000000000155Highly InformativeDirect
Biological Process (BP)angiogenesis0.00032540.000002862Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.000000042390.00000000000687Highly InformativeDirect
Biological Process (BP)myeloid leukocyte activation0.00000001670.0000000003722Highly InformativeDirect
Biological Process (BP)leukocyte activation involved in immune response0.000034160.00006448Highly InformativeDirect
Biological Process (BP)protein phosphorylation0.0000000000000032610.00000000215Highly InformativeDirect
Biological Process (BP)calcium ion transport00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)exocytosis00Highly InformativeDirect
Biological Process (BP)chemotaxis00Highly InformativeDirect
Biological Process (BP)inflammatory response0.00000000000010990Highly InformativeDirect
Biological Process (BP)hemostasis0.000000041030.00000004414Highly InformativeDirect
Biological Process (BP)response to toxic substance0.000079290.0000009794Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.000000027810.0000000004428Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.000015520.00000006271Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration00.000000000002805Highly InformativeDirect
Biological Process (BP)regulation of cyclic nucleotide metabolic process0.0000000068730.00000004224Highly InformativeDirect
Biological Process (BP)positive regulation of defense response0.00018820.00002059Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus00Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide00Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process0.00000000062130.0000000000006111Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death0.0000000035320.00001699Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport00Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade0.000089040.0001212Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.00021010.00004693Highly InformativeDirect
Biological Process (BP)regulation of multi-organism process00Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation00.00000000000004613Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation0.00000000000036870.0000000000001979Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0000013960.0000002228Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion0.0000000056240.0000000000008977Highly InformativeDirect
Biological Process (BP)regulation of behavior00Highly InformativeDirect
Biological Process (BP)coagulation0.00019210.000004676Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.00000000000046440Highly InformativeDirect
Biological Process (BP)leukocyte migration00Highly InformativeDirect
Biological Process (BP)regulation of striated muscle cell differentiation00Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus0.000020970.000005886Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction0.000000003650.000001655Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport0.0000064330.0000004544Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus00Highly InformativeDirect
Biological Process (BP)response to alcohol0.000014290.00001268Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.000000022860.00000001123Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis0.000014570.00000000008137Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration0.070950.001065Highly InformativeInherited
Biological Process (BP)regulation of hormone secretion0.00013960.001017Highly InformativeInherited
Biological Process (BP)regulation of peptide transport0.0078110.03761Highly InformativeInherited
Biological Process (BP)regulation of interleukin-1 beta production0.82450.1789Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.072270.001336Highly InformativeInherited
Biological Process (BP)response to ionizing radiation0.0017160.0007467Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle0.011150.02382Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.32190.006798Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)transferase activity0.0024180.05434Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0000000018690.00007925Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.000000000000069960.000000001175Moderately InformativeDirect
Molecular Function (MF)anion binding0.00023020.00773Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)enzyme activator activity0.00000000086340.00000001139InformativeDirect
Molecular Function (MF)kinase activity0.000000000082430.000008462InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.00000000000078590.000001785InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000010970.00000171InformativeDirect
Molecular Function (MF)sulfur compound binding0.0000000053210.0000002335InformativeDirect
Molecular Function (MF)protein kinase activity0.0000000000000057950.00000002595Highly InformativeDirect
Molecular Function (MF)cytokine activity00Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding00Highly InformativeDirect
Molecular Function (MF)heparin binding00.00000000000008254Highly InformativeDirect
Cellular Component (CC)membrane0.99131Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.25860.9669Moderately InformativeInherited
Cellular Component (CC)extracellular space0.00000000013870InformativeDirect
Cellular Component (CC)cell surface0.00000013030.000000013InformativeDirect
Cellular Component (CC)external side of plasma membrane0.00000000034760.0000001758Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0008207 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02683 Least Informative Inherited
Biological Process (BP) developmental process 0.01908 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0974 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2569 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0.00000001157 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000009119 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00009689 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00001711 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000000002047 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000587 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0005772 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00004016 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00008299 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000001869 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000124 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000005546 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00004318 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8635 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04168 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.6994 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.005948 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6087 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001331 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01319 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9533 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.009876 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.006894 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00000006277 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000000000009575 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) defense response 0.00000000000002119 Informative Direct
Biological Process (BP) immune response 0.0000001297 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000008651 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0003218 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0003099 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00002187 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0004941 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00001196 Informative Direct
Biological Process (BP) phosphorylation 0.0000001352 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0000000000003954 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000001733 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0004732 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) secretion by cell 0.000000000002232 Informative Direct
Biological Process (BP) response to lipid 0.0000008492 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.000000003822 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000001909 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000000002892 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000004177 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0008749 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00000000001324 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00002391 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000002079 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0.9586 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.532 Informative Inherited
Biological Process (BP) regulation of cell development 0.9575 Informative Inherited
Biological Process (BP) regulation of secretion 0.004115 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1857 Informative Inherited
Biological Process (BP) regulation of protein localization 0.4964 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1321 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.03404 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07184 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1647 Informative Inherited
Biological Process (BP) regulation of cell activation 0.1892 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.03761 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.1861 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.3898 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.835 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to bacterium 0.05665 Informative Inherited
Biological Process (BP) regulation of system process 0.1052 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.5493 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7377 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.3532 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) immune effector process 0.1416 Informative Inherited
Biological Process (BP) leukocyte activation 0.04948 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2963 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.09588 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) ossification 0.000000000000155 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000002862 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.00000000000687 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.0000000003722 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.00006448 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00000000215 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) exocytosis 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000004414 Highly Informative Direct
Biological Process (BP) response to virus 0.0002806 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0000009794 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.0007467 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0000000004428 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000006271 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000000000002805 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00000004224 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00002059 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.00003744 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0000000000006111 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.00001699 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0001212 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00004693 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00000000000004613 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0000000000001979 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0000002228 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.0000000000008977 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) coagulation 0.000004676 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0001328 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 0.000005886 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.000001655 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0000004544 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) response to alcohol 0.00001268 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00000001123 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00000000008137 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0.001065 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.1325 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.001017 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.03761 Highly Informative Inherited
Biological Process (BP) regulation of interleukin-1 beta production 0.1789 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.1372 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001336 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.001368 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.02382 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.006798 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.05434 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00007925 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000000001175 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00773 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00000001139 Informative Direct
Molecular Function (MF) kinase activity 0.000008462 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000001785 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000171 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000002335 Informative Direct
Molecular Function (MF) protein kinase activity 0.00000002595 Highly Informative Direct
Molecular Function (MF) cytokine activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000000008254 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.9669 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.000000013 Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000001758 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0189Least InformativeInherited
Disease Ontology (DO)immune system disease0.04037Least InformativeInherited
Disease Ontology (DO)nervous system disease0.9609Least InformativeInherited
Disease Ontology (DO)skin disease0.000000006929Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.000004271Moderately InformativeDirect
Disease Ontology (DO)bacterial infectious disease0.004646Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.07976Moderately InformativeInherited
Disease Ontology (DO)mouth disease0.2034Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.23Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3537Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.6153Moderately InformativeInherited
Disease Ontology (DO)obstructive lung disease0.9747Moderately InformativeInherited
Disease Ontology (DO)arthritis0.00000001801InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0000000326InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000006263InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0002925InformativeDirect
Disease Ontology (DO)periodontitis0.0005633InformativeDirect
Disease Ontology (DO)asthma0.0007629InformativeDirect
Disease Ontology (DO)lymphoma0.006647InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.01207InformativeInherited
Disease Ontology (DO)mature T-cell and NK-cell lymphoma0.0001735Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0003766Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000005775Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00000446Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.6281Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.0000798Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.068Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1006Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2414Moderately InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.000001059InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.00006554Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processChemotaxis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationAntimicrobial0.00005369InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationAntibiotic0.00000091Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001811 SSF54117 Protein matches
Abstract Synonym(s): cytokine, intecrine

Many low-molecular weight factors secreted by cells including fibroblasts, macrophages and endothelial cells, in response to a variety of stimuli such as growth factors, interferons, viral transformation and bacterial products, are structurally related [PubMed1910690, PubMed2149646, PubMed2687068]. Most members of this family of proteins seem to have mitogenic, chemotactic or inflammatory activities. These small cytokines are also called intercrines or chemokines. They are cationic proteins of 70 to 100 amino acid residues that share four conserved cysteine residues involved in two disulphide bonds, as shown in the following schematic representation:

                             +------------------------------------+
                             |                                    |
     xxxxxxxxxxxxxxxxxxxxxxCxCxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxCxxxxx
                           |                         |
                           +-------------------------+

'C': conserved cysteine involved in a disulphide bond.

These proteins can be sorted into two groups based on the spacing of the two amino-terminal cysteines. In the first group (see ), the two cysteines are separated by a single residue (C-x-C), while in the second group (see ), they are adjacent (C-C).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 31 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Interleukin 8-like chemokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 31 hidden Markov models representing the Interleukin 8-like chemokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]