SUPERFAMILY 1.75 HMM library and genome assignments server

Alpha and beta proteins (a+b) class

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Folds:   Microbial ribonucleases [ 53932]
  Lysozyme-like [ 53954]
  Cysteine proteinases [ 54000]
  His-Me finger endonucleases [ 54059]
  RNase A-like [ 54075]
  EndoU-like [ 142876]
  Prion-like [ 54097]
  LysM domain [ 54105]
  gpW/XkdW-like [ 64209] (2)
  Hypothetical protein MTH677 [ 110782]
  GTF2I-like repeat [ 117772]
  Urease, gamma-subunit [ 54110]
  IL8-like [ 54116] (2)
  DNA-binding domain [ 54170]
  Penicillin-binding protein 2x (pbp-2x), c-terminal domain [ 54183]
  Dodecin subunit-like [ 88797] (6)
  Ribosomal proteins S24e, L23 and L15e [ 54188]
  Ribosome binding domain-like [ 100965] (2)
  TFB5-like [ 142896]
  Obg GTP-binding protein C-terminal domain [ 102740]
  HIT-like [ 54196] (2)
  Secretion chaperone-like [ 69634] (5)
  DNA-binding domain of intron-encoded endonucleases [ 64495]
  MotA C-terminal domain-like [ 69651]
  YktB/PF0168-like [ 142912]
  Mago nashi protein [ 89816]
  WGR domain-like [ 142920]
  PH1570-like [ 159901]
  Ribosomal protein S5 domain 2-like [ 54210]
  beta-Grasp (ubiquitin-like) [ 54235] (14)
  MM3350-like [ 159940]
  WWE domain [ 117838]
  FAD-linked reductases, C-terminal domain [ 54372]
  Cystatin-like [ 54402] (7)
  Nuclease A inhibitor (NuiA) [ 82601]
  Colicin D/E5 nuclease domain [ 102823]
  RelE-like [ 143010]
  Hypothetical protein SAV1430 [ 110835]
  Ns1 effector domain-like [ 143020]
  YbaB-like [ 82606]
  Kinetochore globular domain-like [ 143025]
  L35p-like [ 143033]
  Cell division protein ZapA-like [ 102828]
  ssDNA-binding transcriptional regulator domain [ 54446]
  Photosystem I subunit PsaD [ 64233]
  GINS/PriA/YqbF domain [ 160058]
  MHC antigen-recognition domain [ 54451]
  UBC-like [ 54494]
  SAND domain-like [ 63762]
  NRDP1 C-terminal domain-like [ 160087]
  Coronavirus NSP8-like [ 143075]
  ParB/Sulfiredoxin [ 110848]
  Gamma-glutamyl cyclotransferase-like [ 110856]
  BB1717-like [ 143080]
  SARS Nsp1-like [ 160098]
  Acetoacetate decarboxylase-like [ 160103]
  AF0104/ALDC/Ptd012-like [ 117855]
  NSFL1 (p97 ATPase) cofactor p47, SEP domain [ 102847]
  TTHA1013/TTHA0281-like [ 143099]
  YegP-like [ 160112]
  Diaminopimelate epimerase-like [ 54505]
  GFP-like [ 54510]
  Tubby C-terminal domain-like [ 54517]
  Pili subunits [ 54522]
  Mitochondrial glycoprotein MAM33-like [ 54528]
  NAP-like [ 143112]
  Polo-box domain [ 82614]
  mRNA decapping enzyme DcpS N-terminal domain [ 102859]
  Inhibitor of vertebrate lysozyme, Ivy [ 89871]
  FKBP-like [ 54533] (3)
  Ribosomal protein S16 [ 54564]
  Ribosomal protein S19 [ 54569]
  YefM-like [ 143119]
  Ribosomal protein L31e [ 54574]
  Allophycocyanin linker chain (domain) [ 54579]
  Cdc48 domain 2-like [ 54584]
  Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [ 54592]
  Chromosomal protein MC1 [ 102874]
  CPE0013-like [ 160147]
  beta-hairpin-alpha-hairpin repeat [ 74651] (2)
  Proguanylin [ 89889]
  SecB-like [ 54610]
  MesJ substrate recognition domain-like [ 82828]
  FYSH domain [ 89894]
  VSV matrix protein [ 75403]
  DNA-binding domain of Mlu1-box binding protein MBP1 [ 54615]
  Heme-binding protein A (HasA) [ 54620]
  Chalcone isomerase [ 54625]
  Coproporphyrinogen III oxidase [ 102885]
  Hypothetical protein Ta1206 [ 102890]
  CBS-domain pair [ 54630]
  Thioesterase/thiol ester dehydrase-isomerase [ 54636]
  DLC [ 54647]
  CI-2 family of serine protease inhibitors [ 54653]
  Integrin beta tail domain [ 69686]
  YcgL-like [ 160190]
  alpha/beta-Hammerhead [ 54664] (5)
  POZ domain [ 54694]
  EF-Ts domain-like [ 54712] (2)
  Fe,Mn superoxide dismutase (SOD), C-terminal domain [ 54718]
  ClpS-like [ 54735]
  Hypothetical protein MTH1880 [ 75411]
  Ribosomal L11/L12e N-terminal domain [ 54746]
  Anti-LPS factor/recA domain [ 54751] (2)
  Signal recognition particle alu RNA binding heterodimer, SRP9/14 [ 54761]
  dsRBD-like [ 54767] (5)
  2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [ 110920]
  NMB0488-like [ 160206]
  SRP19 [ 69694]
  SufE/NifU [ 82648]
  FlaG-like [ 160213]
  AMPKBI-like [ 160218]
  DNA-binding protein Tfx [ 89914]
  Eukaryotic type KH-domain (KH-domain type I) [ 54790]
  Alpha-lytic protease prodomain-like [ 54805] (10)
  Nucleotidyltransferase [ 81302]
  Nqo5-like [ 143242]
  Ribosomal protein S3 C-terminal domain [ 54820]
  Transcription factor NusA, N-terminal domain [ 69704]
  Enolase N-terminal domain-like [ 54825]
  Ribosomal protein L22 [ 54842]
  Prokaryotic ribosomal protein L17 [ 64262]
  GroEL-intermediate domain like [ 54848]
  PX domain [ 64267]
  Shew3726-like [ 160271]
  DsrC, the gamma subunit of dissimilatory sulfite reductase [ 69720]
  DNA damage-inducible protein DinI [ 54856]
  HSP90 C-terminal domain [ 110941]
  Ferredoxin-like [ 54861] (59)
  PurS-like [ 109622]
  RplX-like [ 160373]
  Dystroglycan, domain 2 [ 111005]
  Pseudouridine synthase [ 100877]
  SP0830-like [ 160378]
  Folate-binding domain [ 103024]
  THUMP domain [ 143436]
  AMMECR1-like [ 143446]
  NosL/MerB-like [ 160386]
  YehU-like [ 118000]
  Hypothetical protein YwqG [ 103031]
  VC0467-like [ 143455]
  Lesion bypass DNA polymerase (Y-family), little finger domain [ 100878]
  ImmE5-like [ 143468]
  Ribosomal protein L30p/L7e [ 55128]
  Chorismate lyase-like [ 64287]
  YdfO-like [ 160418]
  TM1622-like [ 143476]
  BH3703-like [ 160423]
  Probable bacterial effector-binding domain [ 55135]
  CheC-like [ 103038]
  LigT-like [ 55143]
  Pepsin inhibitor-3 [ 55148]
  CYTH-like phosphatases [ 55153]
  Antiparallel beta/alpha barrel (PT-barrel) [ 143491]
  eIF1-like [ 55158] (2)
  Hedgehog/DD-peptidase [ 55165]
  Alpha-L RNA-binding motif [ 55173]
  RRF/tRNA synthetase additional domain-like [ 55185] (4)
  LuxS/MPP-like metallohydrolase [ 63410]
  IF3-like [ 55199] (8)
  PUG domain-like [ 143502]
  PG1857-like [ 160447]
  PB2 C-terminal domain-like [ 160452]
  Ribosome binding protein Y (YfiA homologue) [ 69753]
  TolA/TonB C-terminal domain [ 74652]
  Yeast killer toxins [ 55220]
  Cell division protein MinE topological specificity domain [ 55228]
  Hypothetical protein YoaG [ 103062]
  BLRF2-like [ 160458]
  Nucleocapsid protein dimerization domain [ 103067]
  Cyanase C-terminal domain [ 55233]
  Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [ 82713]
  RuBisCO, small subunit [ 55238]
  DCoH-like [ 55247] (5)
  TRCF domain-like [ 143516]
  NMB0513-like [ 160471]
  PA1123-like [ 160476]
  Hypothetical protein Yml108w [ 100886]
  MutS N-terminal domain-like [ 55266] (2)
  GYF/BRK domain-like [ 55276] (2)
  GTP cyclohydrolase I feedback regulatory protein, GFRP [ 69760]
  RL5-like [ 55281]
  RPB5-like RNA polymerase subunit [ 55286]
  Bacillus chorismate mutase-like [ 55297] (9)
  YjbQ-like [ 111037]
  Tautomerase/MIF [ 55330]
  FwdE/GAPDH domain-like [ 55346] (4)
  Ava3019-like [ 160531]
  Hypothetical protein PF0899 [ 111056]
  Major capsid protein gp5 [ 56562]
  MK0786-like [ 143559]
  YkuJ-like [ 143566]
  N domain of copper amine oxidase-like [ 55382] (5)
  Aha1/BPI domain-like [ 55393] (2)
  SpoVG-like [ 160536]
  Subtilisin inhibitor [ 55398]
  RNA bacteriophage capsid protein [ 55404]
  eIF4e-like [ 55417]
  CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
  SRF-like [ 55454]
  Origin of replication-binding domain, RBD-like [ 55463]
  SARS receptor-binding domain-like [ 143586]
  Hut operon positive regulatory protein HutP [ 111063]
  Hypothetical protein yfbM [ 111068]
  TTHA1528-like [ 143591]
  YojJ-like [ 143596]
  STIV B116-like [ 143601]
  Bacillus phage protein [ 111073]
  FMN-dependent nitroreductase-like [ 55468]
  N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [ 55480]
  EscU C-terminal domain-like [ 160543]
  Zincin-like [ 55485] (2)
  SH2-like [ 55549]
  HPr-like [ 55593] (2)
  TrkA C-terminal domain-like [ 116725]
  Hypothetical protein YjiA, C-terminal domain [ 90001]
  YggU-like [ 69785]
  Homing endonuclease-like [ 55603] (2)
  T-fold [ 55619] (2)
  Cell cycle regulatory proteins [ 55636]
  YonK-like [ 160569]
  BLIP-like [ 55647] (2)
  Ribosomal protein L9 C-domain [ 55652]
  MbtH/L9 domain-like [ 55657] (2)
  Tombusvirus P19 core protein, VP19 [ 103144]
  Ribonuclease PH domain 2-like [ 55665]
  Regulatory factor Nef [ 55670]
  CytB endotoxin-like [ 55675]
  Class II aaRS and biotin synthetases [ 55680]
  Subdomain of clathrin and coatomer appendage domain [ 55710]
  SCP-like [ 55717]
  Ta1353-like [ 103164]
  Mog1p/PsbP-like [ 55723]
  SMI1/KNR4-like [ 160630]
  Acyl-CoA N-acyltransferases (Nat) [ 55728]
  Gelsolin-like [ 55752] (3)
  PHP14-like [ 143723]
  Profilin-like [ 55769] (10)
  Ligand-binding domain in the NO signalling and Golgi transport [ 111125]
  Phage tail protein-like [ 143748]
  PR-1-like [ 55796]
  Phoshotransferase/anion transport protein [ 55803]
  Nudix [ 55810]
  5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [ 55815]
  YrdC/RibB [ 55820]
  GIY-YIG endonuclease [ 82770]
  YbaK/ProRS associated domain [ 55825]
  Thymidylate synthase/dCMP hydroxymethylase [ 55830]
  Thymidylate synthase-complementing protein Thy1 [ 69795]
  N-acetylmuramoyl-L-alanine amidase-like [ 55845]
  Cytochrome b5-like heme/steroid binding domain [ 55855]
  BTG domain-like [ 160695]
  DUSP-like [ 143790]
  DNA topoisomerase I domain [ 55868]
  ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
  YehR-like [ 160703]
  Sporulation response regulatory protein Spo0B [ 55889]
  Ribonuclease Rh-like [ 55894]
  YlxR-like [ 64375]
  YggX-like [ 111147]
  L28p-like [ 143799]
  YqaI-like [ 160712]
  Ornithine decarboxylase C-terminal domain [ 55903]
  Pentein, beta/alpha-propeller [ 55908]
  Creatinase/aminopeptidase [ 55919]
  gpW/gp25-like [ 160718]
  Glutamine synthetase/guanido kinase [ 55930]
  TBP-like [ 55944] (11)
  XisI-like [ 143846]
  S-adenosylmethionine synthetase [ 55972]
  DNA clamp [ 55978]
  Hypothetical protein TM0160 [ 103255]
  TTHC002-like [ 160760]
  Molybdenum cofactor-binding domain [ 56002]
  NE1680-like [ 160765]
  Nitrite and sulphite reductase 4Fe-4S domain-like [ 56013]
  DeoB insert domain-like [ 143855]
  The spindle assembly checkpoint protein mad2 [ 56018]
  Phospholipase D/nuclease [ 56023]
  CorA soluble domain-like [ 143864]
  Monooxygenase (hydroxylase) regulatory protein [ 56028]
  PurM C-terminal domain-like [ 56041]
  PF0523-like [ 143869]
  Chorismate synthase, AroC [ 103262]
  Hsp33 domain [ 64396]
  MTH1598-like [ 69818]
  Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [ 68929]
  OsmC-like [ 82783]
  Hypothetical protein HI1480 [ 103276]
  ERH-like [ 143874]
  Ribosomal protein S8 [ 56046]
  Ribosomal protein L6 [ 56052]
  NE0471 N-terminal domain-like [ 143879]
  Lp2179-like [ 160799]
  RGC domain-like [ 143884]
  Smc hinge domain [ 75552]
  DNA mismatch repair protein MutL [ 118115]
  ATP-grasp [ 56058] (2)
  SAICAR synthase-like [ 56103]
  Protein kinase-like (PK-like) [ 56111]
  FAD-binding/transporter-associated domain-like [ 56175]
  Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [ 56193]
  Methenyltetrahydromethanopterin cyclohydrolase [ 56198]
  Prim-pol domain [ 56746]
  Hect, E3 ligase catalytic domain [ 56203]
  Nitrile hydratase alpha chain [ 56208]
  4'-phosphopantetheinyl transferase [ 56213]
  DNase I-like [ 56218]
  Aldehyde ferredoxin oxidoreductase, N-terminal domain [ 56227]
  Ntn hydrolase-like [ 56234] (2)
  DmpA/ArgJ-like [ 56265]
  Pyruvoyl-dependent histidine and arginine decarboxylases [ 56270]
  S-adenosylmethionine decarboxylase [ 56275]
  Metallo-hydrolase/oxidoreductase [ 56280]
  PP2C-like [ 81607]
  Metallo-dependent phosphatases [ 56299]
  Carbon-nitrogen hydrolase [ 56316]
  CNF1/YfiH-like putative cysteine hydrolases [ 64437]
  ADC synthase [ 56321]
  Sulfolobus fructose-1,6-bisphosphatase-like [ 111248]
  LDH C-terminal domain-like [ 56326]
  DNA breaking-rejoining enzymes [ 56348]
  Replication modulator SeqA, C-terminal DNA-binding domain [ 82807]
  SMAD MH1 domain [ 56365]
  YopH tyrosine phosphatase N-terminal domain [ 64448]
  Rotavirus NSP2 fragment, N-terminal domain [ 75573]
  Rv2827c C-terminal domain-like [ 160886]
  Phosphoprotein oligomerization domain-like [ 160891]
  Taf5 N-terminal domain-like [ 160896]
  Jann2411-like [ 160903]
  ATP12-like [ 160908]
  Ribosome inactivating proteins (RIP) [ 56370]
  ADP-ribosylation [ 56398]
  Peptide deformylase [ 56419]
  LCCL domain [ 69847]
  Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [ 56424]
  C-type lectin-like [ 56435]
  Hemolytic lectin CEL-III, C-terminal domain [ 111264]
  SRCR-like [ 56486] (2)
  Fibrinogen C-terminal domain-like [ 56495]
  gp120 core [ 56501]
  Methionine synthase activation domain-like [ 56506]
  UbiD C-terminal domain-like [ 143967]
  Hypothetical protein TM0875 [ 90063]
  Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
  Suppressor of Fused, N-terminal domain [ 103358]
  Nitric oxide (NO) synthase oxygenase domain [ 56511]
  Penicillin binding protein dimerisation domain [ 56518]
  Oxidoreductase molybdopterin-binding domain [ 56523]
  FAH [ 56528]
  Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [ 56533]
  Substrate-binding domain of HMG-CoA reductase [ 56541]
  Argininosuccinate synthetase, C-terminal domain [ 69863]
  Hypothetical protein PH1602 [ 103364]
  IlvD/EDD N-terminal domain-like [ 143974]
  DNA methylase specificity domain [ 116733]
  GCM domain [ 90072]
  Conserved core of transcriptional regulatory protein vp16 [ 56547]
  Insert subdomain of RNA polymerase alpha subunit [ 56552]
  Baseplate structural protein gp11 [ 56557]
  Receptor-binding domain of short tail fibre protein gp12 [ 88873]
  Outer capsid protein sigma 3 [ 64464]
  Phosphoprotein M1, C-terminal domain [ 118172]
  L,D-transpeptidase pre-catalytic domain-like [ 143984]
  YbiA-like [ 143989]
  NinB [ 103369]
  AF2331-like [ 143994]
  SSo0622-like [ 111277]
  Putative modulator of DNA gyrase, PmbA/TldD [ 111282]
  PSTPO5379-like [ 160919]
  PG1388-like [ 160924]
  Oxysterol-binding protein-like [ 143999]
  ORC1-binding domain [ 144004]
  CofE-like [ 144009]
  Peptidoglycan deacetylase N-terminal noncatalytic region [ 144014]
  Non-globular alpha+beta subunits of globular proteins [ 56567]