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Fe-only hydrogenase superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | Other enzymes |
Document: Function annotation of SCOP domain superfamilies
Gene Ontology (high-coverage) (show details)
Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001
Document: GO annotation of SCOP domains
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: EC annotation of SCOP domains
UniProtKB KeyWords (KW) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: KW annotation of SCOP domains
InterPro annotation
| Cross references | IPR009016 SSF53920 Protein matches |
| Abstract | The iron-only hydrogenases catalyse the two-electron reduction of two protons to yield dihydrogen, as part of an energy cycle. Fe-only hydrogenases are restricted to strictly anaerobic microbes, and are often very sensitive to molecular oxygen. The cytoplasmic monomeric Fe hydrogenases are involved in hydrogen production, while the periplasmic, heterodimeric Fe hydrogenases are involved in hydrogen uptake. Fe hydrogenases consist of two, intertwined domains, the catalytic domain [ 9836629] and the larger subunit C domain [10368269]. The larger subunit C domain can be divided into three subdomains. There are five distinct metal clusters, one in the catalytic domain. This entry represents the two intertwined domains, the catalytic domain and the large subunit C domain. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 2 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Fe-only hydrogenase domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 2 hidden Markov models representing the Fe-only hydrogenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
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