SUPERFAMILY 1.75 HMM library and genome assignments server

PEP carboxykinase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PEP carboxykinase-like [ 53794]
Superfamily:   PEP carboxykinase-like [ 53795] (2)
Families:   PEP carboxykinase C-terminal domain [ 53796] (2)
  HPr kinase HprK C-terminal domain [ 64186]


Superfamily statistics
Genomes (2,726) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,457 26,424 10
Proteins 4,436 26,367 10


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.000003186 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.08376 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9411 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.595 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000000000001705 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0000001226 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.04525 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01123 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.07235 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.003107 Moderately Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0008882 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000005952 Informative Direct
Biological Process (BP) alcohol metabolic process 0.003744 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.001889 Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.000000005431 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.0000000001903 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0000001798 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0 Highly Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) carboxy-lyase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000001848 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationTransferase0.0004925Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)gluconeogenesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PEP carboxykinase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the PEP carboxykinase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]