SUPERFAMILY 1.75 HMM library and genome assignments server

SIS domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   SIS domain [ 53696]
Superfamily:   SIS domain [ 53697] (3)
Families:   mono-SIS domain [ 69599] (5)
  double-SIS domain [ 53698] (4)
  Phosphoglucose isomerase, PGI [ 53701]


Superfamily statistics
Genomes (3,208) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 19,185 140,746 25
Proteins 19,078 140,640 25


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.23291Least InformativeInherited
Biological Process (BP)biosynthetic process0.093170.00002197Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.13680.0005135Least InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0025270.000009547Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0037980Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.0082050.03706Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0016760.000000107Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.000033410.000000001482InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.000026980.000000000000001938InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000045470.00000004305InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process0.00000019960.0000000000009667Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.00000059880.0000000000006053Highly InformativeDirect
Molecular Function (MF)isomerase activity0.000000033410Moderately InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity0.20770.000000007957InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity, interconverting aldoses and ketoses0.00000022230Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00002197 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0005135 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6637 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000009547 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000107 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.03706 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.3399 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.001451 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.000000001482 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000000000000001938 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0000007959 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000004305 Informative Direct
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.000000002638 Highly Informative Direct
Biological Process (BP) glycolysis 0.000000007776 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.0000000000009667 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000003621 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0000000000006053 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000302 Highly Informative Direct
Molecular Function (MF) transferase activity 0.6623 Least Informative Inherited
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0.000000007957 Informative Direct
Molecular Function (MF) transaminase activity 0 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.5603 Least Informative Inherited
Cellular Component (CC) cytosol 0.0004324 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.000000002477Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)Glucokinase0.0000007307Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.00000002017Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processAngiogenesis0.00001699InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0000000000001092Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionZinc0.0000000000001125Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.0000000001816Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0.00004338Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.005716Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)glycolysis0InformativeDirect
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.5544InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0.0000004294Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism0.000001188Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0.0006297Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SIS domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the SIS domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]