SUPERFAMILY 1.75 HMM library and genome assignments server

Alkaline phosphatase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Alkaline phosphatase-like [ 53648]
Superfamily:   Alkaline phosphatase-like [ 53649] (5)
Families:   2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain [ 64162]
  Alkaline phosphatase [ 53650]
  Arylsulfatase [ 53653] (3)
  Phosphonoacetate hydrolase [ 102651]
  DeoB catalytic domain-like [ 142735]


Superfamily statistics
Genomes (3,029) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 24,286 122,139 33
Proteins 23,852 121,688 33


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.093970.8516Least InformativeInherited
Biological Process (BP)multicellular organismal process0.034480.2616Least InformativeInherited
Biological Process (BP)response to stimulus0.39461Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.036390.00000000000004613Least InformativeInherited
Biological Process (BP)protein metabolic process0.10950.0165Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.75731Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000072270.00000000000004773Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.0000032640Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000000013370Moderately InformativeDirect
Biological Process (BP)organ development0.10190.06209Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.026530.05426Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.83710.9017Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.20590.2149Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.000044450.003651Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.67440.3561Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000027810.3881Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.74350.5658Moderately InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.000000021460.0000000001935InformativeDirect
Biological Process (BP)membrane lipid metabolic process0.0000039280.0000000000008566InformativeDirect
Biological Process (BP)organ morphogenesis0.0000018740.0000009375InformativeDirect
Biological Process (BP)response to organic cyclic compound0.00000028720.0003562InformativeDirect
Biological Process (BP)dephosphorylation0.00000000052150.000000004451InformativeDirect
Biological Process (BP)alcohol metabolic process0.00041080.09244InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.050750.8845InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.30940.02215InformativeInherited
Biological Process (BP)skeletal system development0.00000000770Highly InformativeDirect
Biological Process (BP)ossification0.0000000000013070.000002434Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process0.000000011420.000000001548Highly InformativeDirect
Biological Process (BP)response to toxic substance0.0000013660.00001597Highly InformativeDirect
Biological Process (BP)glycosaminoglycan metabolic process0.000000870.000000809Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process00.00000000000004773Highly InformativeDirect
Biological Process (BP)post-translational protein modification0.00000000017850Highly InformativeDirect
Biological Process (BP)sulfur compound catabolic process0.000013520.000001687Highly InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.17691Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding0.0068650.00002562Moderately InformativeInherited
Molecular Function (MF)zinc ion binding0.000096740.00005647InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.29131InformativeInherited
Molecular Function (MF)phosphoric diester hydrolase activity0.000034840.00009626Highly InformativeDirect
Molecular Function (MF)lipase activity11Highly InformativeInherited
Cellular Component (CC)intracellular organelle part0.89781Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.012420.001317Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00024730Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.000000056260Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.0092850.9696Moderately InformativeInherited
Cellular Component (CC)vacuolar part0.00033950.00004199InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.000000045910.0000000197InformativeDirect
Cellular Component (CC)lytic vacuole0.0043910.00004402InformativeInherited
Cellular Component (CC)lysosome00.4205Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000000004613 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.8516 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2616 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.0165 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.00000000000004773 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.02188 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.00705 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.05426 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9017 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2149 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8664 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.02644 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.004819 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.0418 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.003651 Moderately Informative Inherited
Biological Process (BP) system process 0.004051 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3881 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.07919 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6532 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3561 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.002347 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.4199 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5658 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02488 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01938 Moderately Informative Inherited
Biological Process (BP) organ development 0.06209 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7236 Moderately Informative Inherited
Biological Process (BP) muscle system process 0 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.0000000001935 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.0000000000008566 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000008465 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000000301 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.00000001973 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000009375 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00003212 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000005621 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0003562 Informative Direct
Biological Process (BP) dephosphorylation 0.000000004451 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00004774 Informative Direct
Biological Process (BP) biological adhesion 0.000002739 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000000495 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000009279 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000386 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000002352 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0000003771 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000000001676 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.00001411 Informative Direct
Biological Process (BP) alcohol metabolic process 0.09244 Informative Inherited
Biological Process (BP) lipid catabolic process 0.07564 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.05873 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.006837 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.8845 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.02215 Informative Inherited
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) ossification 0.000002434 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.000000001548 Highly Informative Direct
Biological Process (BP) cell adhesion 0.00000165 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000001982 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000000004253 Highly Informative Direct
Biological Process (BP) glycolipid biosynthetic process 0.000002764 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.0007056 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.00001597 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.000000809 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.00000000000001086 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.00000008048 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.00000000000004773 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 0.000001687 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) renal system development 0.0000000000006585 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.000000000000007347 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.0000000000069 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.1071 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 0.1152 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00002562 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.04541 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.2253 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0.00005647 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.00009626 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0.0000003264 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 1 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.0007211 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.001317 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.9696 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1083 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00004402 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000003769 Informative Direct
Cellular Component (CC) cell surface 0.000000000000003095 Informative Direct
Cellular Component (CC) vacuolar part 0.00004199 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000000197 Informative Direct
Cellular Component (CC) lysosome 0.4205 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.000000006922Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000001316Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.3205Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.1016Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Nucleotide diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0Highly InformativeDirect
Enzyme Commission (EC)Phosphodiesterase I4.713e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.003054Moderately InformativeInherited
Disease Ontology (DO)lysosomal storage disease0.0000009571InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.02227Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06422Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.06448Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3951Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01133Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.02845Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.1038Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ribs0.0004046InformativeDirect
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.004139InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.09176InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.09309InformativeInherited
Phenotypic Abnormality (PA)Dysostosis multiplex0.000002271Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion0.000002795Highly InformativeDirect
Phenotypic Abnormality (PA)Coarse facial features0.000003302Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.000298Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.01826Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.1131Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1248Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.005188Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.0005501InformativeDirect
Mammalian Phenotype (MP)abnormal fertility/fecundity0.09101InformativeInherited
Mammalian Phenotype (MP)abnormal glycosaminoglycan level0.000001035Highly InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.0004216Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.5413Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.834Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2075Moderately InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.0003629InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0005159InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0007273InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0007348InformativeDirect
Xenopus ANatomical entity (XAN)kidney0.5304InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.0001135Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.2403Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000000000002156InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001123InformativeInherited
Enzyme Commission (EC)Transferases for other substituted phosphate groups0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.2994Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processHemostasis0.0000001232InformativeDirect
Biological processCell wall biogenesis/degradation0.0003165InformativeDirect
Biological processBlood coagulation0.0000001159Highly InformativeDirect
Biological processLipid degradation0.0000544Highly InformativeDirect
Cellular componentMembrane0.0003091Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell membrane0.000219Moderately InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseObesity0.000001836InformativeDirect
DiseaseMucopolysaccharidosis0Highly InformativeDirect
DomainSignal0.00000000000003508Least InformativeDirect
DomainTransmembrane0.000000000002869Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0.01209Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)glycolysis0InformativeDirect
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)5-phospho-alpha-D-ribose 1-diphosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect
UniPathway (UP)lipoteichoic acid biosynthesis0.00000003382Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Alkaline phosphatase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Alkaline phosphatase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]