SUPERFAMILY 1.75 HMM library and genome assignments server

Purine and uridine phosphorylases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphorylase/hydrolase-like [ 53162] (8)
Superfamily:   Purine and uridine phosphorylases [ 53167]
Families:   Purine and uridine phosphorylases [ 53168] (6)


Superfamily statistics
Genomes (3,102) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,917 56,964 35
Proteins 10,877 56,918 35


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.036530.3761Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.00020050.05813Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0000000092390.02345Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00000029340.05106Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.000000043750.02216Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.000000038030.01798Least InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0000000092940.000000004501Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0000000017430.000006316Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.039860.008012Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0073010.0002668Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.20310.09983Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00031950.3911Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00028260.00881Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.017740.004724Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.080910.3107Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.028730.1752Moderately InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.0000063940.000008511InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process0.0000048580.000005071InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.0000000000087190InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.00002040.0000001743InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000046620.0002042InformativeDirect
Biological Process (BP)alpha-amino acid biosynthetic process0.00011560.0003888InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.0050840.0002285InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process11InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.024980.006931InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.0039210.008474InformativeInherited
Biological Process (BP)amino acid salvage0.00076220.000001785Highly InformativeDirect
Biological Process (BP)pyrimidine ribonucleoside metabolic process0.000034450.0000003575Highly InformativeDirect
Biological Process (BP)L-methionine biosynthetic process0.0000000029460.000000000009253Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process0.56710.9478Highly InformativeInherited
Molecular Function (MF)transferase activity0.0000000001060.000003172Least InformativeDirect
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.00000016960.000007058InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups00Highly InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing N-glycosyl compounds0.0000000000011610.0000000000007825Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.3761 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.05813 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.02345 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.05106 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.02216 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01798 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000000004501 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000006316 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0002668 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.008012 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.09983 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.004724 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3911 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.00881 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3107 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1752 Moderately Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.000008511 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.000005071 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0002285 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0.0000001743 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002042 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0003888 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.006931 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.008474 Informative Inherited
Biological Process (BP) pyrimidine nucleotide metabolic process 0.0003175 Highly Informative Direct
Biological Process (BP) amino acid salvage 0.000001785 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 0.0000003575 Highly Informative Direct
Biological Process (BP) L-methionine biosynthetic process 0.000000000009253 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.9478 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.000003172 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.000007058 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.0000000000007825 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000000000634Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0.00001145Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.000000000000002202Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.8614Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)purine metabolism0.0000008564Moderately InformativeDirect
UniPathway (UP)purine biosynthesis via salvage pathway0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)nucleoside biosynthesis0Highly InformativeDirect
UniPathway (UP)purine nucleoside metabolism0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)pyrimidine salvage0.0000005368Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Purine and uridine phosphorylases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Purine and uridine phosphorylases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]