SUPERFAMILY 1.75 HMM library and genome assignments server

Macro domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Macro domain-like [ 52948]
Superfamily:   Macro domain-like [ 52949] (2)
Families:   Leucine aminopeptidase (Aminopeptidase A), N-terminal domain [ 52950]
  Macro domain [ 89724] (6)


Superfamily statistics
Genomes (2,801) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,564 30,903 15
Proteins 7,016 30,407 15


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)hydrolase activity0.012350.00000006384Least InformativeInherited
Molecular Function (MF)deacetylase activity0.00000000021880.000001012Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.00712 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7761 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.008601 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04854 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01868 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.7308 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2568 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8766 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.00007434 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0004221 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.2083 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.00199 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.000000004849 Informative Direct
Molecular Function (MF) hydrolase activity 0.00000006384 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.0004929 Informative Direct
Molecular Function (MF) deacetylase activity 0.000001012 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.000000000000002098Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.000001337Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0.06619Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0.138Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.00000003657InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.3571Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.000000000000001203Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.000002345InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0.03604InformativeInherited
Enzyme Commission (EC)Omega peptidases0.2241InformativeInherited
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.00000002529Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0InformativeDirect
Biological processViral immunoevasion0.00000000003243InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processInhibition of host IRF3 by virus0Highly InformativeDirect
Biological processInhibition of host ISG15 by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processDecay of host mRNAs by virus0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0.00000000000001625InformativeDirect
Cellular componentHost endosome0Highly InformativeDirect
Cellular componentHost cytoplasmic vesicle0.00000000000004074Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityRNA suppression of termination0InformativeDirect
DomainRepeat0.0005466Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionDNA-binding1Least InformativeInherited
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationEndonuclease0.000000000001481InformativeDirect
Post-translational modificationHelicase0.00000009187InformativeDirect
Post-translational modificationMethyltransferase0.00003397InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationUbl conjugation0.000000000001303Moderately InformativeDirect
Post-translational modificationPalmitate0.000000000001893Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Macro domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Macro domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]