Macro domain-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	Macro domain-like [ 52948]
Superfamily:	Macro domain-like [ 52949] (2)
Families:	Leucine aminopeptidase (Aminopeptidase A), N-terminal domain [ 52950]
	Macro domain [ 89724] (6)

Superfamily statistics

	Genomes (2,166)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	6,149	13,966	15
Proteins	5,696	13,581	15

Functional annotation

General category	Processes_IC
Detailed category	Proteases

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	heterocycle metabolic process	0.01749	0.01311	Least Informative	Inherited
Biological Process (BP)	single-organism metabolic process	0.2394	0.7044	Least Informative	Inherited
Biological Process (BP)	cellular aromatic compound metabolic process	0.0185	0.01662	Least Informative	Inherited
Biological Process (BP)	nitrogen compound metabolic process	0.05045	0.07249	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	0.02733	0.03128	Least Informative	Inherited
Biological Process (BP)	nucleobase-containing small molecule metabolic process	0.003893	7.949e-05	Moderately Informative	Inherited
Biological Process (BP)	carbohydrate derivative metabolic process	0.005169	0.001074	Moderately Informative	Inherited
Molecular Function (MF)	binding	0.1372	1	Least Informative	Inherited
Molecular Function (MF)	hydrolase activity	0.003933	6.688e-09	Least Informative	Inherited
Molecular Function (MF)	deacetylase activity	1.901e-10	6.092e-07	Highly Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	heterocycle metabolic process	0.01311	Least Informative	Inherited
Biological Process (BP)	single-organism metabolic process	0.7044	Least Informative	Inherited
Biological Process (BP)	cellular aromatic compound metabolic process	0.01662	Least Informative	Inherited
Biological Process (BP)	nitrogen compound metabolic process	0.07249	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	0.03128	Least Informative	Inherited
Biological Process (BP)	protein metabolic process	0.6531	Least Informative	Inherited
Biological Process (BP)	cellular macromolecule metabolic process	0.3878	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	response to stimulus	0.7372	Least Informative	Inherited
Biological Process (BP)	cellular response to stress	1.211e-05	Moderately Informative	Direct
Biological Process (BP)	nucleobase-containing small molecule metabolic process	7.949e-05	Moderately Informative	Direct
Biological Process (BP)	cellular protein modification process	0.2759	Moderately Informative	Inherited
Biological Process (BP)	carbohydrate derivative metabolic process	0.001074	Moderately Informative	Inherited
Biological Process (BP)	response to DNA damage stimulus	1.061e-09	Informative	Direct
Molecular Function (MF)	hydrolase activity	6.688e-09	Least Informative	Direct
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	peptidase activity	0.2794	Informative	Inherited
Molecular Function (MF)	exopeptidase activity	5.871e-07	Highly Informative	Direct
Molecular Function (MF)	deacetylase activity	6.092e-07	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	Least Informative	Direct
Enzyme Commission (EC)	Nucleotidyltransferases	2.098e-15	Least Informative	Direct
Enzyme Commission (EC)	Acting on acid anhydrides	1	Least Informative	Inherited
Enzyme Commission (EC)	Acting on ester bonds	1	Least Informative	Inherited
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	0	Moderately Informative	Direct
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	Moderately Informative	Direct
Enzyme Commission (EC)	In phosphorous-containing anhydrides	1.337e-06	Moderately Informative	Direct
Enzyme Commission (EC)	Cysteine endopeptidases	0.06619	Moderately Informative	Inherited
Enzyme Commission (EC)	Omega peptidases	0.138	Moderately Informative	Inherited
Enzyme Commission (EC)	Glycosyltransferases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Aminopeptidases	0	Informative	Direct
Enzyme Commission (EC)	Nucleoside-triphosphatase	0	Informative	Direct
Enzyme Commission (EC)	SARS coronavirus main proteinase	0	Informative	Direct
Enzyme Commission (EC)	RNA-directed RNA polymerase	0	Informative	Direct
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	3.657e-08	Informative	Direct
Enzyme Commission (EC)	Polynucleotide 5'-phosphatase	0	Highly Informative	Direct

Document: EC annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	central nervous system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	gonad	0	Least Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	C globular stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	Least Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	Least Informative	Direct
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.4366	Least Informative	Inherited
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	Moderately Informative	Direct
Enzyme Commission (EC)	Nucleotidyltransferases	1.892e-15	Moderately Informative	Direct
Enzyme Commission (EC)	Glycosyltransferases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on acid anhydrides	1	Moderately Informative	Inherited
Enzyme Commission (EC)	RNA-directed RNA polymerase	0	Informative	Direct
Enzyme Commission (EC)	RNA helicase	0	Informative	Direct
Enzyme Commission (EC)	In phosphorous-containing anhydrides	1.533e-06	Informative	Direct
Enzyme Commission (EC)	Cysteine endopeptidases	0.06442	Informative	Inherited
Enzyme Commission (EC)	Omega peptidases	0.232	Informative	Inherited
Enzyme Commission (EC)	Pentosyltransferases	1	Informative	Inherited
Enzyme Commission (EC)	Polynucleotide 5'-phosphatase	0	Highly Informative	Direct
Enzyme Commission (EC)	Aminopeptidases	0	Highly Informative	Direct
Enzyme Commission (EC)	SARS coronavirus main proteinase	0	Highly Informative	Direct
Enzyme Commission (EC)	Nucleoside-triphosphate phosphatase	0	Highly Informative	Direct
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	2.622e-08	Highly Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Host-virus interaction	0	Moderately Informative	Direct
Biological process	Viral RNA replication	0	Informative	Direct
Biological process	Ubl conjugation pathway	0	Informative	Direct
Biological process	Viral immunoevasion	0	Informative	Direct
Biological process	mRNA capping	0	Highly Informative	Direct
Biological process	Activation of host autophagy by virus	0	Highly Informative	Direct
Biological process	Inhibition of host IRF3 by virus	0	Highly Informative	Direct
Biological process	Inhibition of host ISG15 by virus	0	Highly Informative	Direct
Biological process	Modulation of host ubiquitin pathway by viral deubiquitinase	0	Highly Informative	Direct
Cellular component	Cytoplasm	0	Least Informative	Direct
Cellular component	Membrane	1	Least Informative	Inherited
Cellular component	Host cytoplasm	0	Informative	Direct
Cellular component	Host membrane	0	Informative	Direct
Cellular component	Host nucleus	1.237e-14	Informative	Direct
Cellular component	Host endosome	0	Highly Informative	Direct
Cellular component	Host cytoplasmic vesicle	2.333e-14	Highly Informative	Direct
Coding sequence diversity	Ribosomal frameshifting	0	Moderately Informative	Direct
Coding sequence diversity	RNA suppression of termination	0	Informative	Direct
Domain	Repeat	0.0009429	Least Informative	Direct
Molecular function	Metal-binding	0	Least Informative	Direct
Molecular function	Nucleotide-binding	1	Least Informative	Inherited
Molecular function	Manganese	0	Moderately Informative	Direct
Molecular function	DNA-binding	1	Moderately Informative	Inherited
Molecular function	Helicase	0	Informative	Direct
Post-translational modification	Hydrolase	0	Least Informative	Direct
Post-translational modification	Transferase	1	Least Informative	Inherited
Post-translational modification	Nucleotidyltransferase	0	Moderately Informative	Direct
Post-translational modification	Protease	0	Moderately Informative	Direct
Post-translational modification	Nuclease	1	Moderately Informative	Inherited
Post-translational modification	Exonuclease	0	Informative	Direct
Post-translational modification	Endonuclease	9.014e-12	Informative	Direct
Post-translational modification	Methyltransferase	0.000147	Informative	Direct
Post-translational modification	Aminopeptidase	0	Highly Informative	Direct
Post-translational modification	RNA-directed RNA polymerase	0	Highly Informative	Direct
Post-translational modification	Ubl conjugation	2.004e-13	Moderately Informative	Direct
Post-translational modification	Palmitate	8.022e-13	Moderately Informative	Direct

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Macro domain-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Macro domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Macro domain-like superfamily