SUPERFAMILY 1.75 HMM library and genome assignments server


Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]


Superfamily statistics
Genomes (3,246) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 134,046 496,606 301
Proteins 121,851 472,930 292


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process0.8371Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.52041Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.052520Least InformativeInherited
Biological Process (BP)response to stimulus0.00091620.1063Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.99830.9523Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular response to stress5.826e-135.63e-11Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus1.311e-096.961e-11Moderately InformativeDirect
Biological Process (BP)regulation of localization0.044941Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function7.202e-051Moderately InformativeInherited
Biological Process (BP)organ development0.79811Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.8261Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.77941Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.066391Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.10871Moderately InformativeInherited
Biological Process (BP)reproduction0.18811Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.11068.351e-09Moderately InformativeInherited
Biological Process (BP)organelle organization0.73661Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process10Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.031810Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0010210.008242Moderately InformativeInherited
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)response to inorganic substance6.093e-100InformativeDirect
Biological Process (BP)regulation of intracellular transport3.914e-071.522e-10InformativeDirect
Biological Process (BP)developmental process involved in reproduction0.009411InformativeInherited
Biological Process (BP)reproductive system development0.00035120.5829InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0075250.01316InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0030770.01276InformativeInherited
Biological Process (BP)regulation of protein localization0.000320.1216InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0068670.01161InformativeInherited
Biological Process (BP)secondary metabolic process0.27457.205e-14InformativeInherited
Biological Process (BP)peptide metabolic process0.0011650InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.24530InformativeInherited
Biological Process (BP)protein folding1.241e-120Highly InformativeDirect
Biological Process (BP)glutathione metabolic process1.81e-050Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process8.271e-091.326e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species1.576e-060Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide1.847e-066.22e-11Highly InformativeDirect
Biological Process (BP)cell redox homeostasis00Highly InformativeDirect
Biological Process (BP)regulation of binding8.225e-110.0002397Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus1.734e-125.665e-10Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process5.242e-101.509e-09Highly InformativeDirect
Biological Process (BP)post-embryonic development0.0021741Highly InformativeInherited
Biological Process (BP)post-embryonic organ development1.184e-060.09522Highly InformativeInherited
Biological Process (BP)icosanoid metabolic process1.609e-090.005532Highly InformativeInherited
Biological Process (BP)hydrogen peroxide metabolic process0.0030528.087e-06Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport1.354e-060.006927Highly InformativeInherited
Biological Process (BP)regulation of nucleocytoplasmic transport2.45e-060.06903Highly InformativeInherited
Biological Process (BP)response to superoxide0.25530.02175Highly InformativeInherited
Biological Process (BP)superoxide metabolic process11Highly InformativeInherited
Biological Process (BP)toxin metabolic process0.001710Highly InformativeInherited
Biological Process (BP)nucleus organization0.006870.02686Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity10.5827Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity6.644e-070Moderately InformativeDirect
Molecular Function (MF)anion binding10.9907Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.00013413.846e-05InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity3.899e-150InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors11InformativeInherited
Molecular Function (MF)carboxylic acid binding0.2692.332e-15InformativeInherited
Molecular Function (MF)amide binding0.0066271.961e-13InformativeInherited
Molecular Function (MF)sulfur compound binding0.043690InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.0059080InformativeInherited
Molecular Function (MF)glutathione transferase activity3.234e-100Highly InformativeDirect
Molecular Function (MF)antioxidant activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on peroxide as acceptor00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.00019120.001502Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.022540.4794Highly InformativeInherited
Molecular Function (MF)amino acid binding0.029840Highly InformativeInherited
Molecular Function (MF)peptide binding0.0048843.027e-14Highly InformativeInherited
Cellular Component (CC)cytoplasmic part1.26e-050Least InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0002560.05945Least InformativeInherited
Cellular Component (CC)respiratory chain0.26780.5887InformativeInherited
Cellular Component (CC)plastid0.088691.279e-13InformativeInherited
Cellular Component (CC)chloroplast stroma7.693e-061.742e-07Highly InformativeDirect
Cellular Component (CC)respiratory chain complex I1.515e-052.353e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1063 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9523 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 5.63e-11 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 8.351e-09 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 6.961e-11 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.8779 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.008242 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) secondary metabolic process 7.205e-14 Informative Direct
Biological Process (BP) regulation of intracellular transport 1.522e-10 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.0891 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 0.5829 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01316 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.01276 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9941 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01572 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1216 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.07581 Informative Inherited
Biological Process (BP) regulation of defense response 0.7687 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.5151 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.8402 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.01161 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.5943 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.2593 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.0948 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.003012 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.7097 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.2952 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0002052 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 1.326e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 6.22e-11 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 8.087e-06 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0002397 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 5.665e-10 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 1.509e-09 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0003249 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.006521 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1775 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.0274 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.09522 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.005532 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.4038 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.00128 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.006927 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.06903 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.834 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4604 Highly Informative Inherited
Biological Process (BP) cell projection assembly 1 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.9947 Highly Informative Inherited
Biological Process (BP) peptidyl-proline modification 0.009732 Highly Informative Inherited
Biological Process (BP) response to superoxide 0.02175 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.01304 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7698 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.2599 Highly Informative Inherited
Biological Process (BP) innate immune response 0.09296 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.03448 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.02686 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.01925 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.2139 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.5827 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.9907 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 3.846e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 2.332e-15 Informative Direct
Molecular Function (MF) amide binding 1.961e-13 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.6384 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) glutathione transferase activity 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0 Highly Informative Direct
Molecular Function (MF) peptide binding 3.027e-14 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.4794 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.001502 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0.00609 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.05945 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.352e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 0.4162 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.04428 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.4978 Moderately Informative Inherited
Cellular Component (CC) plastid 1.279e-13 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0005099 Informative Direct
Cellular Component (CC) respiratory chain 0.5887 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.01399 Informative Inherited
Cellular Component (CC) microbody 0.04746 Informative Inherited
Cellular Component (CC) chloroplast stroma 1.742e-07 Highly Informative Direct
Cellular Component (CC) respiratory chain complex I 2.353e-05 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.01126 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases4.463e-09Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)9.784e-11InformativeDirect
Enzyme Commission (EC)With other acceptors1.562e-10InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.31e-06InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases1.046e-09Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases4.643e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.02177Least InformativeInherited
Disease Ontology (DO)immune system disease1Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.0402Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.5889Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.7462Moderately InformativeInherited
Disease Ontology (DO)esophageal disease0.0008798InformativeDirect
Disease Ontology (DO)malignant glioma0.7512InformativeInherited
Disease Ontology (DO)normocytic anemia0.01132Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3348Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.002759Moderately InformativeInherited
Mammalian Phenotype (MP)oxidative stress3.067e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002023Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02693Least InformativeInherited
Worm Phenotype (WP)organism stress response variant1.958e-10InformativeDirect
Worm Phenotype (WP)metal response variant0.0002078InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.002744Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.02836Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0001307Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.07829Moderately InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.07956InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.1289InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.0004808Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell6.211e-06Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.000211Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0008895Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.001641Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006633Least InformativeInherited
Plant ANatomical entity (PAN)flower0.02078Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.05778Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.09687Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1687Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6222Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.389InformativeInherited
Plant ANatomical entity (PAN)phloem0.0003851Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1.921e-10Moderately InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.9248InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)5.038e-11Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase4.798e-07Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases3.691e-06Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1.198e-05Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002243Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0003756Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor0.1281Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation0.001994Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processStress response1.224e-08InformativeDirect
Biological processSensory transduction0.03137InformativeInherited
Biological processFatty acid metabolism0.4629InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSpermatogenesis6.625e-12Highly InformativeDirect
Biological processPhenylalanine catabolism5.076e-11Highly InformativeDirect
Biological processTwo-component regulatory system1.12e-10Highly InformativeDirect
Biological processUnfolded protein response6.726e-09Highly InformativeDirect
Biological processSodium transport4.315e-08Highly InformativeDirect
Biological processNitrate assimilation8.787e-08Highly InformativeDirect
Biological processAuxin signaling pathway1.577e-07Highly InformativeDirect
Biological processVision5.351e-05Highly InformativeDirect
Biological processAntiport7.688e-05Highly InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion6.331e-15Moderately InformativeDirect
Cellular componentPlastid5.897e-05Moderately InformativeDirect
Cellular componentCell projection0.4222Moderately InformativeInherited
Cellular componentPeriplasm1.253e-14InformativeDirect
Cellular componentChloroplast1.37e-07InformativeDirect
Cellular componentPeroxisome7.526e-07InformativeDirect
Cellular componentSarcoplasmic reticulum1.754e-13Highly InformativeDirect
Cellular componentLipid droplet1.133e-06Highly InformativeDirect
Cellular componentCilium6.394e-05Highly InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DiseaseAllergen0.0001122Moderately InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainTransit peptide1.826e-15Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainSH3-binding1.919e-06InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular function2Fe-2S0InformativeDirect
Molecular functionIron-sulfur1.406e-13InformativeDirect
Molecular functionSodium0.0001661InformativeDirect
Molecular functionCopper0.0008483InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Molecular functionUbiquinone5.809e-05Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase2.153e-10Moderately InformativeDirect
Post-translational modificationIon channel1.185e-05InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel1.413e-14Highly InformativeDirect
Post-translational modificationEye lens protein4.582e-08Highly InformativeDirect
Post-translational modificationMuscle protein6.351e-06Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationS-nitrosylation0.0007246InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0001081Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.1658Least InformativeInherited
UniPathway (UP)lipid metabolism0.7648Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.9597Least InformativeInherited
UniPathway (UP)amino-acid degradation2.6e-09Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation8.167e-07Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.0001Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.0187Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.46Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0.004054InformativeInherited
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)methylamine degradation1.926e-14Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis9.832e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches
Abstract

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]