SUPERFAMILY 1.75 HMM library and genome assignments server


Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]


Superfamily statistics
Genomes (2,482) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 109,213 236,061 301
Proteins 98,817 223,695 292


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process0.85491Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.97651Least InformativeInherited
Biological Process (BP)response to stimulus0.019870.1893Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.10840Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular response to stress5.515e-113.982e-08Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process04.833e-12Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus2.04e-074.593e-09Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.00029160.0001837Moderately InformativeDirect
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.043190.8718Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.8341Moderately InformativeInherited
Biological Process (BP)organ development0.86741Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.76371Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.7071Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.26290.5283Moderately InformativeInherited
Biological Process (BP)homeostatic process0.00030070.03958Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.013641Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.046011Moderately InformativeInherited
Biological Process (BP)reproduction0.26681Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.51235.43e-08Moderately InformativeInherited
Biological Process (BP)organelle organization0.76631Moderately InformativeInherited
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)response to inorganic substance9.348e-080InformativeDirect
Biological Process (BP)regulation of intracellular transport2.616e-081.563e-12InformativeDirect
Biological Process (BP)regulation of protein localization2.697e-050.0132InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0068831InformativeInherited
Biological Process (BP)reproductive system development0.00028970.6259InformativeInherited
Biological Process (BP)fatty acid metabolic process0.057850.02033InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.021340.06077InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds0.24310.8534InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0093410.0009685InformativeInherited
Biological Process (BP)oxidative phosphorylation2.052e-140Highly InformativeDirect
Biological Process (BP)protein folding8.379e-100Highly InformativeDirect
Biological Process (BP)toxin metabolic process0.00077090Highly InformativeDirect
Biological Process (BP)respiratory electron transport chain0.00021950.0001636Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process9.181e-077.747e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species8.739e-060Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide1.386e-053.262e-11Highly InformativeDirect
Biological Process (BP)icosanoid biosynthetic process1.064e-072.608e-08Highly InformativeDirect
Biological Process (BP)regulation of binding5.237e-100.0004539Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus3.332e-124.06e-11Highly InformativeDirect
Biological Process (BP)post-embryonic development0.0029980.892Highly InformativeInherited
Biological Process (BP)post-embryonic organ development1.207e-060.03682Highly InformativeInherited
Biological Process (BP)hydrogen peroxide metabolic process0.048330.002519Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport7.249e-070.00443Highly InformativeInherited
Biological Process (BP)regulation of nucleocytoplasmic transport9.302e-050.1888Highly InformativeInherited
Biological Process (BP)response to superoxide0.012971.297e-05Highly InformativeInherited
Biological Process (BP)superoxide metabolic process0.9060.9155Highly InformativeInherited
Biological Process (BP)nucleus organization0.011450.01351Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity10.3117Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.00060050Moderately InformativeDirect
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.00029954.92e-05InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity1.23e-100InformativeDirect
Molecular Function (MF)carboxylic acid binding0.30271.308e-10InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.0020720InformativeInherited
Molecular Function (MF)NADH dehydrogenase activity0.00012610.0001632Highly InformativeDirect
Molecular Function (MF)glutathione transferase activity6.765e-100Highly InformativeDirect
Molecular Function (MF)peroxidase activity0.00042129.552e-05Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.00035840.1048Highly InformativeInherited
Molecular Function (MF)peptide binding0.0043171.816e-11Highly InformativeInherited
Molecular Function (MF)modified amino acid binding0.0065340Highly InformativeInherited
Molecular Function (MF)sulfur compound binding0.03593.543e-12Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors11Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.00058730Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.7861Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0003610.008593Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)mitochondrial part1.114e-062.419e-07Moderately InformativeDirect
Cellular Component (CC)organelle envelope0.0035919.31e-09Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.053184.264e-06Moderately InformativeInherited
Cellular Component (CC)mitochondrial membrane part9.016e-120InformativeDirect
Cellular Component (CC)respiratory chain00InformativeDirect
Cellular Component (CC)plastid0.10354.38e-13InformativeInherited
Cellular Component (CC)mitochondrial respiratory chain complex I4.059e-120Highly InformativeDirect
Cellular Component (CC)ferredoxin hydrogenase complex4.121e-051.504e-07Highly InformativeDirect
Cellular Component (CC)chloroplast stroma1.535e-052.741e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1893 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 3.982e-08 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 5.43e-08 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 4.833e-12 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.593e-09 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0001837 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8718 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.5283 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.03958 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3346 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000136 Informative Direct
Biological Process (BP) regulation of intracellular transport 1.563e-12 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0009685 Informative Direct
Biological Process (BP) regulation of system process 0.8979 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1202 Informative Inherited
Biological Process (BP) regulation of protein localization 0.0132 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 0.6259 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.02033 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.06077 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8044 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.8534 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01837 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.209 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.784 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.7836 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.132 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.2286 Informative Inherited
Biological Process (BP) response to other organism 0.2653 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.4822 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.1848 Informative Inherited
Biological Process (BP) anion transport 0.92 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.95 Informative Inherited
Biological Process (BP) response to superoxide 1.297e-05 Highly Informative Direct
Biological Process (BP) oxidative phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0001969 Highly Informative Direct
Biological Process (BP) respiratory electron transport chain 0.0001636 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 7.747e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 3.262e-11 Highly Informative Direct
Biological Process (BP) icosanoid biosynthetic process 2.608e-08 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0004539 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 4.06e-11 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0001512 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00287 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.06868 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.9188 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.892 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.03682 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 1 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 0.002519 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.00443 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1888 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.7932 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.9962 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.8535 Highly Informative Inherited
Biological Process (BP) peptidyl-proline modification 0.1681 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 0.9155 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.1433 Highly Informative Inherited
Biological Process (BP) innate immune response 0.573 Highly Informative Inherited
Biological Process (BP) cellular glucan metabolic process 0.003869 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.01351 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.00887 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.1623 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.3117 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 4.92e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.308e-10 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.482 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) NADH dehydrogenase activity 0.0001632 Highly Informative Direct
Molecular Function (MF) glutathione transferase activity 0 Highly Informative Direct
Molecular Function (MF) peroxidase activity 9.552e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) peptide binding 1.816e-11 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) sulfur compound binding 3.543e-12 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.1048 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0.005968 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.008593 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 4.264e-06 Moderately Informative Direct
Cellular Component (CC) organelle envelope 9.31e-09 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 2.419e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region 0.9688 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02389 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plastid 4.38e-13 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0 Informative Direct
Cellular Component (CC) respiratory chain 0 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.001278 Informative Inherited
Cellular Component (CC) microbody 0.08027 Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain complex I 0 Highly Informative Direct
Cellular Component (CC) ferredoxin hydrogenase complex 1.504e-07 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 2.741e-07 Highly Informative Direct
Cellular Component (CC) organelle subcompartment 2.218e-07 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.00274 Highly Informative Inherited
Cellular Component (CC) microbody part 0.05515 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases4.463e-09Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)9.784e-11InformativeDirect
Enzyme Commission (EC)With other acceptors1.562e-10InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.31e-06InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases1.046e-09Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases4.643e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06349Least InformativeInherited
Disease Ontology (DO)immune system disease1Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.003899Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.07067Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.3768Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4406Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5323Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.8726Moderately InformativeInherited
Disease Ontology (DO)esophageal disease0.000106InformativeDirect
Disease Ontology (DO)adenoma0.0002053InformativeDirect
Disease Ontology (DO)anemia0.1218InformativeInherited
Disease Ontology (DO)malignant glioma0.6063InformativeInherited
Disease Ontology (DO)peptic esophagitis0.0001089Highly InformativeDirect
Disease Ontology (DO)vitiligo0.0003173Highly InformativeDirect
Disease Ontology (DO)normocytic anemia0.02404Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.5143Least InformativeInherited
Phenotypic Abnormality (PA)Increased CSF lactate0.0001956Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4391Least InformativeInherited
Mammalian Phenotype (MP)oxidative stress3.726e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002023Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02693Least InformativeInherited
Worm Phenotype (WP)organism stress response variant1.958e-10InformativeDirect
Worm Phenotype (WP)metal response variant0.0002078InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.006457Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure8.581e-05Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.04571Moderately InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.06989InformativeInherited
Xenopus ANatomical entity (XAN)pronephric nephron0.0001444Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)androecium8.518e-07Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0001992Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0.0002405Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0.0003553Least InformativeDirect
Plant ANatomical entity (PAN)stem0.0004276Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0.0007575Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0.0117Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1598Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6157Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.1482InformativeInherited
Plant ANatomical entity (PAN)phloem0.0003608Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases3.409e-09Moderately InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.7723InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)8.669e-11Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase4.766e-07Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases3.772e-06Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor8.264e-06Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002136Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.00108Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donor0.1174Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antidotes0Moderately InformativeDirect
Drugbank ATC_code (DB)glutathione0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation0.001019Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processStress response6.887e-09InformativeDirect
Biological processSensory transduction0.02802InformativeInherited
Biological processFatty acid metabolism0.4616InformativeInherited
Biological processBiological rhythms0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processThyroid hormones biosynthesis0Highly InformativeDirect
Biological processVoltage-gated channel1.47e-14Highly InformativeDirect
Biological processSpermatogenesis4.176e-12Highly InformativeDirect
Biological processTyrosine catabolism1.266e-11Highly InformativeDirect
Biological processPhenylalanine catabolism4.92e-11Highly InformativeDirect
Biological processTwo-component regulatory system8.664e-11Highly InformativeDirect
Biological processUnfolded protein response1.811e-09Highly InformativeDirect
Biological processSodium transport4.223e-08Highly InformativeDirect
Biological processNitrate assimilation6.523e-08Highly InformativeDirect
Biological processAuxin signaling pathway1.223e-07Highly InformativeDirect
Biological processAntiport9.128e-06Highly InformativeDirect
Biological processVision5.21e-05Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion3.144e-15Moderately InformativeDirect
Cellular componentPlastid4.357e-05Moderately InformativeDirect
Cellular componentCell projection0.2051Moderately InformativeInherited
Cellular componentPeriplasm5.32e-15InformativeDirect
Cellular componentPeroxisome2.401e-06InformativeDirect
Cellular componentSarcoplasmic reticulum5.485e-14Highly InformativeDirect
Cellular componentChloroplast1.473e-07Highly InformativeDirect
Cellular componentLipid droplet2.119e-07Highly InformativeDirect
Cellular componentCilium2.256e-05Highly InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DiseaseAllergen2.044e-05Moderately InformativeDirect
DomainTransit peptide3.922e-14Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainSH3-binding3.687e-06InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionIron0.4022Moderately InformativeInherited
Molecular function2Fe-2S0InformativeDirect
Molecular functionIron-sulfur3.256e-13InformativeDirect
Molecular functionSodium0.000173InformativeDirect
Molecular functionCopper0.0007884InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Molecular functionUbiquinone6.054e-05Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase3.658e-10Moderately InformativeDirect
Post-translational modificationIon channel7.812e-06InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationEye lens protein4.833e-08Highly InformativeDirect
Post-translational modificationMuscle protein6.637e-06Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationS-nitrosylation8.617e-07InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0001017Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.1703Least InformativeInherited
UniPathway (UP)lipid metabolism0.7653Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.9583Least InformativeInherited
UniPathway (UP)amino-acid degradation2.591e-09Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation6.943e-07Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism9.748e-05Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.01917Moderately InformativeInherited
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)methylamine degradation2.008e-14Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis8.577e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches
Abstract

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]