SUPERFAMILY 1.75 HMM library and genome assignments server

(Phosphotyrosine protein) phosphatases II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   (Phosphotyrosine protein) phosphatases II [ 52798]
Superfamily:   (Phosphotyrosine protein) phosphatases II [ 52799] (5)
Families:   Dual specificity phosphatase-like [ 52800] (8)
  Higher-molecular-weight phosphotyrosine protein phosphatases [ 52805] (6)
  Myotubularin-like phosphatases [ 102422]
  Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA [ 117583]
  Mycobacterial PtpB-like [ 142348]


Superfamily statistics
Genomes (1,847) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,173 41,029 63
Proteins 24,936 37,693 60


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.49450.8726Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0069010.008077Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.072191Least InformativeInherited
Biological Process (BP)response to stimulus0.12630.0000001041Least InformativeInherited
Biological Process (BP)multicellular organismal process0.18180.00000000001565Least InformativeInherited
Biological Process (BP)developmental process0.3560Least InformativeInherited
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)signal transduction0.0000048530.000000002304Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.000000028540.0000000001504Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.000066410Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000021880Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.0000000011310Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000000020850Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.027450.127Moderately InformativeInherited
Biological Process (BP)response to organic substance0.070511Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.23230.1535Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.23081Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.3680.9851Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.70880.02658Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.047711Moderately InformativeInherited
Biological Process (BP)regulation of localization0.64570.00003548Moderately InformativeInherited
Biological Process (BP)immune system process0.20650.000000006909Moderately InformativeInherited
Biological Process (BP)organ development0.091950.1489Moderately InformativeInherited
Biological Process (BP)cell differentiation0.31451Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation00.0000000003998InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00020220.0000000001577InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade00.00000000000003459InformativeDirect
Biological Process (BP)negative regulation of cell communication0.0000000000060710InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)negative regulation of signaling0.00000000000042630InformativeDirect
Biological Process (BP)negative regulation of catalytic activity0.0000052790InformativeDirect
Biological Process (BP)regulation of kinase activity00.000000001491InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.00022280InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.00000000021140InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process0.00000000074810InformativeDirect
Biological Process (BP)response to organonitrogen compound0.083320.00004145InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0098870.002231InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.034890.001482InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.36080.1423InformativeInherited
Biological Process (BP)regulation of cell activation0.0033650.0000002169InformativeInherited
Biological Process (BP)negative regulation of immune system process0.0014560.000003277InformativeInherited
Biological Process (BP)regulation of immune response0.46710.4216InformativeInherited
Biological Process (BP)positive regulation of immune system process0.17070.0000002298InformativeInherited
Biological Process (BP)regulation of secretion0.23991InformativeInherited
Biological Process (BP)negative regulation of transport0.24450.4194InformativeInherited
Biological Process (BP)intracellular signal transduction0.0070160.1094InformativeInherited
Biological Process (BP)regulation of immune effector process0.0050690.007589InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00060640.001611InformativeInherited
Biological Process (BP)protein dephosphorylation00Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade0.000012590.0000001116Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00000000054140Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.00000000020190Highly InformativeDirect
Biological Process (BP)regulation of MAP kinase activity0.000015420Highly InformativeDirect
Biological Process (BP)regulation of T cell activation0.000034020.000000000000001938Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.00043920.00000000005186Highly InformativeDirect
Biological Process (BP)immune response-activating signal transduction0.0094910.0004368Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway0.21580.000007488Highly InformativeInherited
Biological Process (BP)regulation of hormone secretion0.093651Highly InformativeInherited
Biological Process (BP)negative regulation of secretion0.0014120.02721Highly InformativeInherited
Biological Process (BP)regulation of peptide transport0.0041040.08906Highly InformativeInherited
Biological Process (BP)regulation of adaptive immune response based on somatic recombination of immune receptors built from10.9001Highly InformativeInherited
Biological Process (BP)negative regulation of immune response0.0052040.0123Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)phosphoprotein phosphatase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000001565 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000001041 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000002529 Least Informative Direct
Biological Process (BP) localization 0.007589 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8726 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.008077 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.000000006909 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000000002304 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000000009216 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0000000001504 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00003548 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.1833 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1535 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7801 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4521 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4686 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6962 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9851 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002386 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.02658 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.1489 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.0113 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.127 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.624 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02809 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9169 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8084 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.0000000003998 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000003277 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000002298 Informative Direct
Biological Process (BP) cellular component movement 0.0000000007135 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0006324 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000000001577 Informative Direct
Biological Process (BP) blood circulation 0.0000001508 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001566 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00004145 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.00000000000003459 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) biological adhesion 0.0000000000004423 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000000002963 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.00001677 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000000004158 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0 Informative Direct
Biological Process (BP) regulation of kinase activity 0.000000001491 Informative Direct
Biological Process (BP) regulation of system process 0.0008256 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) regulation of cell activation 0.0000002169 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0000000002918 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00002229 Informative Direct
Biological Process (BP) localization of cell 0.00001993 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.2974 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1423 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2636 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.05081 Informative Inherited
Biological Process (BP) cell cycle process 0.7342 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.06008 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001482 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.4304 Informative Inherited
Biological Process (BP) metal ion transport 0.8068 Informative Inherited
Biological Process (BP) cation homeostasis 0.8951 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.09988 Informative Inherited
Biological Process (BP) epithelium development 0.5131 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) organelle localization 0.2089 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1094 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.002511 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.526 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.02321 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.004076 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.007122 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.4194 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.01661 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4416 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) defense response 0.02657 Informative Inherited
Biological Process (BP) immune response 0.2969 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9566 Informative Inherited
Biological Process (BP) single-organism behavior 0.1849 Informative Inherited
Biological Process (BP) regulation of growth 0.5144 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) gland development 0.2966 Informative Inherited
Biological Process (BP) immune effector process 0.03632 Informative Inherited
Biological Process (BP) secondary metabolic process 0.5593 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.09535 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.002231 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.6286 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.2429 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.5826 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2468 Informative Inherited
Biological Process (BP) generation of neurons 0.7173 Informative Inherited
Biological Process (BP) leukocyte activation 0.1462 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.001611 Informative Inherited
Biological Process (BP) central nervous system development 0.0265 Informative Inherited
Biological Process (BP) lipid localization 0.1178 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6212 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.576 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.0579 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1395 Informative Inherited
Biological Process (BP) regulation of immune response 0.4216 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.007589 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000000008765 Highly Informative Direct
Biological Process (BP) negative regulation of immune effector process 0.0002687 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0004368 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.000007488 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.00002928 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000000002793 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0000000005581 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.000000004283 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0007185 Highly Informative Direct
Biological Process (BP) response to virus 0.0002123 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.000003514 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0000142 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.0000000001363 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0000001116 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00006074 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.00000000003126 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00002935 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000002169 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000002094 Highly Informative Direct
Biological Process (BP) B cell activation 0.00003661 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0000006641 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0000000000003569 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0000000001246 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000000001607 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000000000000001938 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000008499 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0000003107 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000006706 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0000001407 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0000001469 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.00009636 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0003165 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.00000000001177 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00000000005186 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000000001243 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.00003993 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.5787 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.02689 Highly Informative Inherited
Biological Process (BP) renal system development 0.01803 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.003714 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.0299 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.09487 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.08106 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.406 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.001787 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2244 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.5194 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.1263 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.001385 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7287 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.138 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.003162 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.02007 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.4526 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5006 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.5351 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.02721 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.08906 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.02557 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.001274 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.3519 Highly Informative Inherited
Biological Process (BP) innate immune response 0.01866 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1234 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.00163 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.4864 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.4773 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.1853 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.006195 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.5337 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.1251 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.0146 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.8064 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.002561 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.1518 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.0123 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.9001 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.3549 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.001345 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.03179 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3655 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0.0000004196 Informative Direct
Molecular Function (MF) enzyme binding 0.00000148 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000007082 Informative Direct
Molecular Function (MF) sulfur compound binding 0.03504 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.07212 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.4676 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.08678 Informative Inherited
Molecular Function (MF) lipid binding 0.06038 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0007087 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.000000008232 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0001354 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0002185 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.00000001009 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.01842 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.13 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.04585 Highly Informative Inherited
Cellular Component (CC) membrane 0.000000000002502 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.00000000003644 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000007581 Moderately Informative Direct
Cellular Component (CC) cell junction 0.000000001337 Informative Direct
Cellular Component (CC) cell leading edge 0.00000001582 Informative Direct
Cellular Component (CC) extracellular matrix 0.7507 Informative Inherited
Cellular Component (CC) neuron projection 0.03741 Informative Inherited
Cellular Component (CC) adherens junction 0.00000000000001332 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00000003212 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000001031 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.1124 Highly Informative Inherited
Cellular Component (CC) dendrite 0.001002 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.02851 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000002129InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.09781Least InformativeInherited
Fly Anatomy (FA)organ system0.1431Least InformativeInherited
Fly Anatomy (FA)larva0.1751Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01271Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.01284Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2002Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.01518InformativeInherited
Fly Anatomy (FA)nerve0.09819InformativeInherited
Fly Anatomy (FA)intersegmental nerve0.0005618Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0005842Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.03226Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.1187Least InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.001645Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0001029InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.0008178InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000001488Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase0.0000000183Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)musculo-skeletal system0Moderately InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.00005073Moderately InformativeDirect
Biological processHost-virus interaction0.01402Moderately InformativeInherited
Biological processCell adhesion0.0000000003016InformativeDirect
Biological processViral immunoevasion0.0000168InformativeDirect
Biological processMeiosis0.00003252InformativeDirect
Biological processStress response0.0003442InformativeDirect
Biological processMitosis0.000527InformativeDirect
Biological processVirulence0.00099InformativeDirect
Biological processCilium biogenesis/degradation0.000000006554Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.000001048Least InformativeDirect
Cellular componentCytoplasm0.001324Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndosome0.0000000000001323Moderately InformativeDirect
Cellular componentCell junction0.000000000001478Moderately InformativeDirect
Cellular componentCell projection0.000000000227Moderately InformativeDirect
Cellular componentHost cytoplasm0.000006181InformativeDirect
Coding sequence diversityAlternative splicing0.0003726Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.0004167Moderately InformativeDirect
Developmental stageLate protein0.00000006196Least InformativeDirect
DomainRepeat0.00000009384Least InformativeDirect
DomainSignal0.0000001027Least InformativeDirect
DomainTransmembrane0.00001861Least InformativeDirect
DomainCoiled coil0.00002725Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainImmunoglobulin domain0.000000000000003925InformativeDirect
Molecular functionHeparin-binding0.000001365InformativeDirect
Molecular functionActin-binding0.00006239InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationReceptor0.000000000000514Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)phospholipid metabolism0InformativeDirect
UniPathway (UP)phosphatidylglycerol biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Phosphotyrosine protein) phosphatases II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the (Phosphotyrosine protein) phosphatases II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]