SUPERFAMILY 1.75 HMM library and genome assignments server

Arginase/deacetylase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Arginase/deacetylase [ 52767]
Superfamily:   Arginase/deacetylase [ 52768] (2)
Families:   Arginase-like amidino hydrolases [ 52769] (4)
  Histone deacetylase, HDAC [ 52773] (3)


Superfamily statistics
Genomes (2,295) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,835 38,581 30
Proteins 10,512 38,239 30


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.54990Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.0000001268Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00039581Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.27681Least InformativeInherited
Biological Process (BP)single-organism cellular process0.97720.00002046Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.032210Least InformativeInherited
Biological Process (BP)biosynthetic process0.62711Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.26770.00000000002156Least InformativeInherited
Biological Process (BP)regulation of cellular process0.32780.000344Least InformativeInherited
Biological Process (BP)organelle organization0.000068240Moderately InformativeDirect
Biological Process (BP)cellular protein modification process0.0072730Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00045440.2496Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.057020.0699Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.040691Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.10411Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.0000047720.04679Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.082080.00000000000004613Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.11110Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.32330.0000001419Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.40030.000000001959Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.09620.0000000000002433Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.61770.000000002908Moderately InformativeInherited
Biological Process (BP)chromosome organization0.0000000000017680InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.000062260.004922InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.0054190.3261InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.00000040441InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.012730.08788InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.0096810.00000000000003459InformativeInherited
Biological Process (BP)negative regulation of gene expression0.0059290.0000000000002418InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.015980InformativeInherited
Biological Process (BP)polyamine metabolic process0.0000000000064060.0000000008151Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process0.0000010910.000002625Highly InformativeDirect
Biological Process (BP)histone modification0.00000019480Highly InformativeDirect
Biological Process (BP)protein deacylation0.00000000000011670Highly InformativeDirect
Biological Process (BP)negative regulation of transcription, DNA-dependent0.0026930.0000000000001457Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00000000000017160Least InformativeDirect
Molecular Function (MF)binding0.17240.0001379Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.042350.0007797Moderately InformativeInherited
Molecular Function (MF)cation binding0.0050140.04531Moderately InformativeInherited
Molecular Function (MF)chromatin binding0.000061860InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds00InformativeDirect
Molecular Function (MF)DNA binding0.0041710.000001779InformativeInherited
Molecular Function (MF)transcription factor binding0.000000089630Highly InformativeDirect
Molecular Function (MF)deacetylase activity0.00000000039620Highly InformativeDirect
Molecular Function (MF)manganese ion binding0.00028020.0002433Highly InformativeDirect
Molecular Function (MF)structure-specific DNA binding0.00002710.00003022Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.21110.00001212Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.027510.000008527Least InformativeInherited
Cellular Component (CC)protein complex0.12190.00000000001352Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.00081880.00000000001582Moderately InformativeDirect
Cellular Component (CC)nuclear part0.017350.000000294Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00000018190InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.00000000002156 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000001268 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00002046 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000344 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.3026 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.07745 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.002619 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000000000004613 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000001419 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000000001959 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00002069 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0000000000002433 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000000002908 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00003084 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002649 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.8381 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.006246 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2993 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01171 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.5462 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0502 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1184 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6838 Moderately Informative Inherited
Biological Process (BP) organ development 0.6528 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.04679 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.006355 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2496 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.0699 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8843 Moderately Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.00000000000003459 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0001818 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0000000000002418 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0001513 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000000445 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.002908 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.5343 Informative Inherited
Biological Process (BP) regulation of cell development 0.006534 Informative Inherited
Biological Process (BP) generation of neurons 0.5979 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.9932 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.002477 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01018 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.004724 Informative Inherited
Biological Process (BP) leukocyte activation 0.008422 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1478 Informative Inherited
Biological Process (BP) central nervous system development 0.5851 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.004922 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.3261 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.01009 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.03422 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.08788 Informative Inherited
Biological Process (BP) ossification 0.000001366 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.0000000008151 Highly Informative Direct
Biological Process (BP) learning or memory 0.00001573 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.000000004994 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.00000001328 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000002625 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) gene silencing 0.0000008797 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.00000001125 Highly Informative Direct
Biological Process (BP) electron transport chain 0.0000000231 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.0000002942 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0001011 Highly Informative Direct
Biological Process (BP) protein deacylation 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0001575 Highly Informative Direct
Biological Process (BP) B cell activation 0.000007248 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.00004268 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.00000005966 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.0000000000001457 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00006372 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.00004697 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.000008933 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.02882 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.06405 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.003629 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.009226 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.005021 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.04248 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.006111 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.01215 Highly Informative Inherited
Molecular Function (MF) binding 0.0001379 Least Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.0007797 Moderately Informative Direct
Molecular Function (MF) cation binding 0.04531 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.000001779 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) enzyme binding 0.005541 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.1727 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00000399 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0.0002433 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.00003022 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00003661 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000008527 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000001352 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00001212 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.6792 Least Informative Inherited
Cellular Component (CC) nuclear part 0.000000294 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.00000000001582 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000003892 Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.04418 Informative Inherited
Cellular Component (CC) chromatin 0.00000000000006153 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In linear amides0.8808Moderately InformativeInherited
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Behavioral abnormality0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Growth delay0InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0379Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.006432Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01235Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.0007281InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.0008559InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.07034Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1108Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.000004679InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0002554InformativeDirect
Worm Phenotype (WP)organism stress response variant0.0006462InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.000000005449Highly InformativeDirect
Worm Phenotype (WP)organism UV hypersensitive0.0000004442Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic agents0.00005638Moderately InformativeDirect
Drugbank ATC_code (DB)other antineoplastic agents0.00000004713InformativeDirect
Drugbank ATC_code (DB)vorinostat0.00000000000003458Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processBiological rhythms0.0000008807InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processHistidine metabolism0Highly InformativeDirect
Biological processPolyamine biosynthesis0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainTransit peptide0.0005031Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationPhosphoprotein0.00001743Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000001741Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000001327Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.00000000002621Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0InformativeDirect
UniPathway (UP)putrescine metabolism0InformativeDirect
UniPathway (UP)urea cycle0Highly InformativeDirect
UniPathway (UP)L-histidine degradation0Highly InformativeDirect
UniPathway (UP)putrescine biosynthesis via agmatine pathway0Highly InformativeDirect
UniPathway (UP)ketone degradation1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Arginase/deacetylase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Arginase/deacetylase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]