SUPERFAMILY 1.75 HMM library and genome assignments server

SGNH hydrolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   SGNH hydrolase [ 52266] (9)
Families:   Esterase [ 52267]
  Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1 [ 52270]
  Acetylhydrolase [ 52273] (2)
  Rhamnogalacturonan acetylesterase [ 52276]
  TAP-like [ 89594] (2)
  Hypothetical protein alr1529 [ 102240]
  Putative acetylxylan esterase-like [ 142058] (2)
  YxiM C-terminal domain-like [ 159482]
  BT2961-like [ 159485] (2)


Superfamily statistics
Genomes (2,587) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 19,931 75,294 19
Proteins 19,586 74,211 19


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.039181Least InformativeInherited
Biological Process (BP)reproduction0.00018820.09111Moderately InformativeInherited
Biological Process (BP)sexual reproduction0.00000036250.00118InformativeInherited
Biological Process (BP)single organism reproductive process0.00000082640.04888InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.00000048460.03292InformativeInherited
Biological Process (BP)spermatogenesis0.00000000094220.0004673Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.013390.0000000006729Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.00021550Moderately InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.0000061050.00000000000009884Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.3647 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.000006322 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.002388 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1149 Moderately Informative Inherited
Biological Process (BP) reproduction 0.09111 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.0000001006 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.001271 Informative Inherited
Biological Process (BP) regulation of defense response 0.01214 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0821 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.003451 Informative Inherited
Biological Process (BP) sexual reproduction 0.00118 Informative Inherited
Biological Process (BP) single organism reproductive process 0.04888 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.03292 Informative Inherited
Biological Process (BP) spermatogenesis 0.0004673 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.000000004357 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.000002929 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000000006729 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) lipase activity 0.000003001 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.00000000000009884 Highly Informative Direct
Cellular Component (CC) external encapsulating structure 0.00002956 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Sialate O-acetylesterase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.8483Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0.00000000002081Moderately InformativeDirect
Biological processVirus entry into host cell4.711e-16InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Cellular componentMembrane0.002164Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0.0000000495Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR013830 SSF52266 Protein matches
Abstract

This entry represents the SGNH hydrolase-type esterase domain, which has a similar fold to flavoproteins, namely a three-layer alpha/beta/alpha structure, where the beta-sheets are composed of five parallel strands. Enzymes containing this domain act as esterases and lipases, but have little sequence homology to true lipases [PubMed10801485, PubMed15522763]. Proteins containing this type of esterase domain have been found in a variety of hydrolases; those with structural information include an esterase from Streptomyces scabies [PubMed7773790]; the esterase domain of viral haemagglutinin-esterase surface glycoproteins (influenza C virus, coronaviruses and toroviruses) [PubMed9817207]; mammalian acetylhydrolases [PubMed11522926]; fungal rhamnogalacturonan acetylesterase [PubMed11752785]; and the multifunctional enzyme thioesterase I (TAP) from Escherichia coli [PubMed12842470]. SGNH hydrolase-type esterase domains contain unique hydrogen bond network that stabilizes their catalytic centres; they usually contain the catalytic triad Ser/Acid/His.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SGNH hydrolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 14 hidden Markov models representing the SGNH hydrolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]