SUPERFAMILY 1.75 HMM library and genome assignments server

Uracil-DNA glycosylase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Uracil-DNA glycosylase-like [ 52140]
Superfamily:   Uracil-DNA glycosylase-like [ 52141] (4)
Families:   Uracil-DNA glycosylase [ 52142]
  Mug-like [ 52147] (3)
  Single-strand selective monofunctional uracil-DNA glycosylase SMUG1 [ 89579]
  AF0587 domain-like [ 159464]


Superfamily statistics
Genomes (3,191) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,942 33,140 20
Proteins 6,931 33,120 20


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.000000012730Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.00000035130Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.000000075360Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.000000011830Least InformativeDirect
Biological Process (BP)response to stimulus0.0008430.0000008612Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000000049210Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0031840.01212Least InformativeInherited
Biological Process (BP)cellular response to stress0.000000000037620Moderately InformativeDirect
Biological Process (BP)DNA metabolic process0.0000000047090InformativeDirect
Biological Process (BP)response to DNA damage stimulus0.0000000000000016880InformativeDirect
Molecular Function (MF)hydrolase activity0.000000093650Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing N-glycosyl compounds00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000008612 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.4422 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01212 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.134 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.08055 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.9931 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.9815 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02585 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1044 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.003273 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06937 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8107 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.8306 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9485 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0.0004826 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0002685 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0002226 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0001768 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.9117 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.1495 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.001106 Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.000005462 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00006723 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00000002118 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0.001204 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.9995 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0001901 Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.000002581 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0000002506 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000174 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.09498 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000002678 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.003014 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.258 Informative Inherited
Cellular Component (CC) nuclear body 0.00000002668 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)oviduct0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA excision0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005122 SSF52141 Protein matches
Abstract

Uracil-DNA glycosylase (UNG) is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of misincorportation of dUMP residues by DNA polymerase or deamination of cytosine. The sequence of uracil-DNA glycosylase is extremely well conserved [PubMed2555154].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Uracil-DNA glycosylase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Uracil-DNA glycosylase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]