SUPERFAMILY 1.75 HMM library and genome assignments server

PLC-like phosphodiesterases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   PLC-like phosphodiesterases [ 51695] (3)
Families:   Mammalian PLC [ 51696] (2)
  Bacterial PLC [ 51699]
  Glycerophosphoryl diester phosphodiesterase [ 89508] (4)


Superfamily statistics
Genomes (2,514) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,201 55,278 17
Proteins 12,727 54,939 17


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.30740.00000002287Least InformativeInherited
Biological Process (BP)lipid metabolic process0.00044340Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.027730.000000000000003755Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0020070Moderately InformativeInherited
Biological Process (BP)phospholipid metabolic process0.00000019350InformativeDirect
Molecular Function (MF)hydrolase activity0.0000011340Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0000000000007870Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.0010460InformativeInherited
Molecular Function (MF)phosphoric diester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)lipase activity0.00035420Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000002287 Least Informative Direct
Biological Process (BP) localization 0.1038 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2705 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2334 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8279 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2649 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1524 Least Informative Inherited
Biological Process (BP) developmental process 0.8452 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) ion transport 0.0002483 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0004851 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00001162 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0008948 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00000004184 Moderately Informative Direct
Biological Process (BP) organ development 0.3289 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6929 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5583 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.07761 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4365 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2889 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04025 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8912 Moderately Informative Inherited
Biological Process (BP) system process 0.2692 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1681 Moderately Informative Inherited
Biological Process (BP) immune system process 0.193 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.06588 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0000000000771 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 0.0001483 Informative Direct
Biological Process (BP) metal ion transport 0.00000009082 Informative Direct
Biological Process (BP) regulation of locomotion 0.0006024 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000002899 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0001528 Informative Direct
Biological Process (BP) cation homeostasis 0.4553 Informative Inherited
Biological Process (BP) embryonic organ development 0.0262 Informative Inherited
Biological Process (BP) cardiovascular system development 0.09621 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001832 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.00573 Informative Inherited
Biological Process (BP) organelle localization 0.2204 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.12 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.01573 Informative Inherited
Biological Process (BP) cellular component movement 0.1207 Informative Inherited
Biological Process (BP) actin filament-based process 0.01619 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.5626 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.003927 Informative Inherited
Biological Process (BP) sexual reproduction 0.07631 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03541 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.01484 Informative Inherited
Biological Process (BP) regulation of immune response 0.08836 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5684 Informative Inherited
Biological Process (BP) angiogenesis 0.0004146 Highly Informative Direct
Biological Process (BP) placenta development 0.0002272 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.00005573 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.0009187 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0000000000007507 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0009411 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.0000001651 Highly Informative Direct
Biological Process (BP) fertilization 0.0000003401 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.00005397 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.00000007241 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0009839 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000000000009724 Highly Informative Direct
Biological Process (BP) sensory perception 0.07463 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5423 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.002742 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.1505 Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.05995 Highly Informative Inherited
Cellular Component (CC) membrane 0.0009067 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.944 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.00002948 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00001617 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.3033 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.9924 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.1953 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.5348 Moderately Informative Inherited
Cellular Component (CC) synapse part 0.03777 Informative Inherited
Cellular Component (CC) anchored to membrane 0.000001959 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000001001InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.327Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7636Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.003753InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.01054InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.00002396Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.00007818Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.007523Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.02032Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1195Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.00003637Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.00004553Moderately InformativeDirect
Worm Phenotype (WP)cell stress response variant0.00000001767InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0000000222InformativeDirect
Worm Phenotype (WP)copulation variant0.001263InformativeInherited
Worm Phenotype (WP)protein expression variant0.01288InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)osmotic stress response variant0Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant7.484e-16Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.00000000000001045Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00000000000006858Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00000000007006Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.000009643Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.00001068Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0002097Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.0009183Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0.00000003506Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processVirulence0.0009619InformativeDirect
Biological processHemolysis0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processFertilization0.000000000002791Highly InformativeDirect
Biological processGlycerol metabolism0.000000000008958Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0.0009237Moderately InformativeDirect
DomainSignal0.00002498Least InformativeDirect
DomainSH2 domain0.00000007132InformativeDirect
DomainSH3 domain0.00002175InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationZymogen0.0002856InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PLC-like phosphodiesterases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PLC-like phosphodiesterases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]