SUPERFAMILY 1.75 HMM library and genome assignments server

Metallo-dependent hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Metallo-dependent hydrolases [ 51556] (18)
Families:   Adenosine/AMP deaminase [ 51557] (2)
  Dihydroorotase [ 63917]
  Cytosine deaminase catalytic domain [ 69390]
  alpha-subunit of urease, catalytic domain [ 51560]
  Hydantoinase (dihydropyrimidinase), catalytic domain [ 75073] (5)
  SAH/MTA deaminase-like [ 82258] (3)
  Isoaspartyl dipeptidase, catalytic domain [ 89489]
  N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain [ 82261]
  D-aminoacylase, catalytic domain [ 82264]
  TatD Mg-dependent DNase-like [ 82267] (4)
  Phosphotriesterase-like [ 51564] (2)
  Renal dipeptidase [ 75079]
  Uronate isomerase-like [ 75082] (2)
  Adenine deaminase-like [ 141816]
  PP1699/LP2961-like [ 141819] (5)
  DR0824-like [ 159397]
  Imidazolonepropionase-like [ 159400] (3)
  Zn-dependent arginine carboxypeptidase-like [ 159408] (3)


Superfamily statistics
Genomes (3,231) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 42,238 204,219 96
Proteins 41,952 203,900 96


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.000000000003520Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000000003890Least InformativeDirect
Biological Process (BP)response to stimulus0.15061Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0020631Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.012990.00000000000004447Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.037580.000000000003547Least InformativeInherited
Biological Process (BP)regulation of cellular process0.15981Least InformativeInherited
Biological Process (BP)single-organism cellular process0.531Least InformativeInherited
Biological Process (BP)biosynthetic process0.65480.3144Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.018530Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.0000000011350.0000000004485Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.0000000000055290.000005379Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00005280.00000001157Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00000000003450.00007776Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00023060.00000005997Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000057980.0000001604Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00000000057660.1033Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00000019340.8352Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.000000069830.001287Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.77980.9924Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.19370.9994Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.13960.00001349Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.091860Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.000014280.002792Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.075360.00000009401Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.14550.00000000002961Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.041550.00000000001654Moderately InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.000000000000024560.000000002489InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.000000098160.000459InformativeDirect
Biological Process (BP)apoptotic process00.00000008257InformativeDirect
Biological Process (BP)regulation of locomotion00.000000000000001938InformativeDirect
Biological Process (BP)negative regulation of catalytic activity00.00000001374InformativeDirect
Biological Process (BP)regulation of cellular component movement00InformativeDirect
Biological Process (BP)regulation of peptidase activity00.00000000002182InformativeDirect
Biological Process (BP)negative regulation of cell death0.0000000000000016880.0000005706InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.0000000028280.000000002073InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.00085360.0000005645InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process0.00000011860.0001496InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.021090.6282InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.078940InformativeInherited
Biological Process (BP)response to inorganic substance0.083610.6278InformativeInherited
Biological Process (BP)response to oxidative stress0.00012040.1075InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.5760.7962InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.0041240.05979InformativeInherited
Biological Process (BP)pigment metabolic process0.20690.2071InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.000045320.2103InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.0090370.01798InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.41330.000002631InformativeInherited
Biological Process (BP)nucleobase metabolic process0.0000330Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity00Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.00006710.0003517Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion00Highly InformativeDirect
Biological Process (BP)response to drug00.00000000008037Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process00.00000003776Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process00Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement00Highly InformativeDirect
Biological Process (BP)response to calcium ion0.000000000076440.000005279Highly InformativeDirect
Biological Process (BP)cellular response to metal ion0.00000020380.0002044Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.0008610Highly InformativeDirect
Biological Process (BP)pigment biosynthetic process0.016150.001001Highly InformativeInherited
Biological Process (BP)purine ribonucleoside catabolic process0.0000028410.0164Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0000000000000076450Least InformativeDirect
Molecular Function (MF)binding0.32361Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.000000000000053290.00004391Moderately InformativeDirect
Molecular Function (MF)cation binding00.0000001165Moderately InformativeDirect
Molecular Function (MF)anion binding0.025930.7939Moderately InformativeInherited
Molecular Function (MF)lyase activity0.027480.5553Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity00.000000000000001562InformativeDirect
Molecular Function (MF)zinc ion binding00.000000000008085InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.00000000066880InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.000001060.00001303InformativeDirect
Molecular Function (MF)carboxylic acid binding00.00000000000002331InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)lipid binding0.00015430.112InformativeInherited
Molecular Function (MF)peptidase activity0.000020791InformativeInherited
Molecular Function (MF)cysteine-type endopeptidase inhibitor activity00Highly InformativeDirect
Molecular Function (MF)metallopeptidase activity00.0000000000001326Highly InformativeDirect
Molecular Function (MF)exopeptidase activity00Highly InformativeDirect
Molecular Function (MF)amino acid binding00Highly InformativeDirect
Molecular Function (MF)deaminase activity00Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding0.00000000032120.0005168Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process00Highly InformativeDirect
Molecular Function (MF)glycolipid binding0.0000000000024680.0000000006804Highly InformativeDirect
Molecular Function (MF)carboxy-lyase activity0.00014830.007843Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000003547 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000000004447 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3144 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000000004485 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000005379 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000001157 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00007776 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000001654 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000005997 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000009401 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000001604 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00001349 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000000002961 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1033 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5242 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.05444 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6098 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.8352 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001287 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9924 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9994 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4534 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.002792 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.000000002489 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000459 Informative Direct
Biological Process (BP) apoptotic process 0.00000008257 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00002039 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000000001938 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.00000001374 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.00000000003426 Informative Direct
Biological Process (BP) protein oligomerization 0.0000005184 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.00000000002182 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000005706 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000000002073 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000005645 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000002631 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.0001496 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.6282 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6278 Informative Inherited
Biological Process (BP) response to oxidative stress 0.1075 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.7962 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.02187 Informative Inherited
Biological Process (BP) actin filament-based process 0.06102 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1685 Informative Inherited
Biological Process (BP) organelle localization 0.1195 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.08546 Informative Inherited
Biological Process (BP) response to wounding 0.05599 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.05979 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2071 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.2103 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8868 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.007811 Informative Inherited
Biological Process (BP) generation of neurons 0.189 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.05543 Informative Inherited
Biological Process (BP) regulation of cell development 0.1325 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.7504 Informative Inherited
Biological Process (BP) single-organism behavior 0.4826 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.03081 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.01798 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.0001818 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0001225 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00008113 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0003517 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) response to drug 0.00000000008037 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.00000003776 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0.0000000000002403 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.000000002645 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.000005279 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.0002044 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.001001 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.006604 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.01337 Highly Informative Inherited
Biological Process (BP) learning or memory 0.0282 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.0164 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.00004391 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0000001165 Moderately Informative Direct
Molecular Function (MF) anion binding 0.7939 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.5553 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.000000000000001562 Informative Direct
Molecular Function (MF) zinc ion binding 0.000000000008085 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.00001303 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000000000002331 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000001455 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000199 Informative Direct
Molecular Function (MF) lipid binding 0.112 Informative Inherited
Molecular Function (MF) receptor binding 0.004364 Informative Inherited
Molecular Function (MF) ligase activity 0.8456 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.008948 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.0000000000001326 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.0001072 Highly Informative Direct
Molecular Function (MF) deaminase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0001894 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.0005168 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.0000000006804 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.007843 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.00004107 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0005144 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.8016 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.09374 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.377 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.00004155 Informative Direct
Cellular Component (CC) cell leading edge 0.00008464 Informative Direct
Cellular Component (CC) neuron projection 0.0001052 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.008813 Informative Inherited
Cellular Component (CC) transport vesicle 0.000000007032 Highly Informative Direct
Cellular Component (CC) growth cone 0.000000001825 Highly Informative Direct
Cellular Component (CC) cell body 0.000000003622 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.6788Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)In cyclic amides0InformativeDirect
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Urease0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dihydroorotase0.0000002676Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.03753Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.01936Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3933Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neurite morphology0.02622Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.6755Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect
Enzyme Commission (EC)In cyclic amides0Highly InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHistidine metabolism0Highly InformativeDirect
Biological processNucleotide metabolism0Highly InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentGPI-anchor0.000001213InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0.0009132Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationMetalloprotease0.0000004803InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.1749Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.8977Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)purine degradation0.00000001516InformativeDirect
UniPathway (UP)purine biosynthesis via salvage pathway0.01605InformativeInherited
UniPathway (UP)purine base metabolism0.9574InformativeInherited
UniPathway (UP)ureide metabolism0.9597InformativeInherited
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)pentose and glucuronate interconversion0Highly InformativeDirect
UniPathway (UP)urea degradation0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0Highly InformativeDirect
UniPathway (UP)L-histidine degradation0Highly InformativeDirect
UniPathway (UP)cell surface structure biogenesis0.003558Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 52 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallo-dependent hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 52 hidden Markov models representing the Metallo-dependent hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]