SUPERFAMILY 1.75 HMM library and genome assignments server

NAD(P)-linked oxidoreductase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   NAD(P)-linked oxidoreductase [ 51430]
Families:   Aldo-keto reductases (NADP) [ 51431] (15)


Superfamily statistics
Genomes (2,701) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,367 106,644 47
Proteins 25,168 106,509 47


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000000022950.000000000002104Least InformativeDirect
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.96131Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.77520.5798Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.34131Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.68531Least InformativeInherited
Biological Process (BP)multicellular organismal process0.73181Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000028840.0000151Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.00069670.0001786Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.00078370.000004866Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00000041650.00002454Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.81461Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0020160.2641Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.056310.593Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.81880.8146Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.078380.194Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.59181Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.22861Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.062310.07733Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.52170.6209Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.4231Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.8361Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.48710.4702Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.15460.08796Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.15850.9068Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.5441Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.076260.5807Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.045070.2418Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.12120.05696Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.017670.9089Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.0010890.000257Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.17330.2086Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.83911Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)organic substance transport0.97291Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process00InformativeDirect
Biological Process (BP)peptide metabolic process0.000000091260.000001421InformativeDirect
Biological Process (BP)isoprenoid metabolic process0.0000025030.0000006932InformativeDirect
Biological Process (BP)response to oxidative stress0.000000014690.0000001055InformativeDirect
Biological Process (BP)regulation of hormone levels0.000000064560.00000005538InformativeDirect
Biological Process (BP)secondary metabolic process0.000053350.00008663InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.0000000026590.00000000000146InformativeDirect
Biological Process (BP)amide biosynthetic process0.0000062230.00000005854InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.000013960.000002452InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.39260.2904InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.016830.1859InformativeInherited
Biological Process (BP)response to organic cyclic compound0.056510.4655InformativeInherited
Biological Process (BP)response to hormone stimulus0.0030320.06558InformativeInherited
Biological Process (BP)response to lipid0.033780.1863InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.001050.003579InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.11480.7946InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.027280.5011InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.14631InformativeInherited
Biological Process (BP)response to inorganic substance0.092630.04797InformativeInherited
Biological Process (BP)regulation of ion transport0.23220.1302InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.0027230.0001877InformativeInherited
Biological Process (BP)vitamin metabolic process0.0019650.00005947InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.04030.04743InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.00065640.01247InformativeInherited
Biological Process (BP)lipid catabolic process0.0017650.001437InformativeInherited
Biological Process (BP)alcohol metabolic process0.000005350.001041InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.0013040.00009309InformativeInherited
Biological Process (BP)hexose metabolic process11InformativeInherited
Biological Process (BP)protein transport0.38920.7816InformativeInherited
Biological Process (BP)cytoplasmic transport0.24860.5888InformativeInherited
Biological Process (BP)protein localization to organelle0.078170.3015InformativeInherited
Biological Process (BP)retinoid metabolic process0.00000000049730.000000000004268Highly InformativeDirect
Biological Process (BP)galactose metabolic process0.0000021390.00001138Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process0.00000040910.00001122Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00000000029210.00000001919Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process0.00000067110.0000006138Highly InformativeDirect
Biological Process (BP)digestion0.0000000013530.00000001497Highly InformativeDirect
Biological Process (BP)glycoside metabolic process0.000000000007420Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process0.000000086540.00000004926Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.00045350.00005059Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.000000000015110.000000000001017Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.000000017830.000000007118Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.0003170.0002917Highly InformativeDirect
Biological Process (BP)peptide biosynthetic process0.000000000034830.00000000001138Highly InformativeDirect
Biological Process (BP)alcohol catabolic process0.00049010.0001735Highly InformativeDirect
Biological Process (BP)aldehyde catabolic process0.000016940.000002731Highly InformativeDirect
Biological Process (BP)response to cadmium ion0.0000018390.000007766Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00000035120.000001375Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process0.0000023820.00000675Highly InformativeDirect
Biological Process (BP)regulation of ligase activity0.000000044740.00000007424Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade0.0000060.0001772Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.0006930.000489Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species metabolic process0.000082790.0008052Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death0.021410.08979Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.00025130.006829Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.020510.002864Highly InformativeInherited
Biological Process (BP)regulation of transporter activity0.0033450.0004171Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.093560.04642Highly InformativeInherited
Biological Process (BP)response to calcium ion0.00053170.00393Highly InformativeInherited
Biological Process (BP)monosaccharide biosynthetic process0.15730.1772Highly InformativeInherited
Biological Process (BP)pentose metabolic process0.0013640.0001934Highly InformativeInherited
Biological Process (BP)protein import0.00093080.01068Highly InformativeInherited
Biological Process (BP)protein localization to nucleus0.00058330.007045Highly InformativeInherited
Biological Process (BP)protein targeting to nucleus0.00013180.002364Highly InformativeInherited
Biological Process (BP)nuclear import0.00015860.00267Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.21090.5217Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)nucleotide binding0.45950.7055InformativeInherited
Molecular Function (MF)cofactor binding0.039240.0327InformativeInherited
Molecular Function (MF)enzyme binding0.00015630.09734InformativeInherited
Molecular Function (MF)carboxylic acid binding0.0067140.005528InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H0.13430.3665InformativeInherited
Molecular Function (MF)lipid binding0.0037580.01903InformativeInherited
Molecular Function (MF)receptor activity0.23761InformativeInherited
Molecular Function (MF)molecular transducer activity0.31431InformativeInherited
Molecular Function (MF)steroid binding0.0000072910.000002081Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor0.00086580.00005768Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding0.0002170.00003291Highly InformativeDirect
Molecular Function (MF)NADP binding0.000014840.00001208Highly InformativeDirect
Molecular Function (MF)monooxygenase activity0.30881Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.97531Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors0.082540.1304Highly InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity0.031520.1024Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors0.63380.5961Highly InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.18440.5601Least InformativeInherited
Cellular Component (CC)cytosol0.000000066960.0000008566Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.97350.5899Moderately InformativeInherited
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)integral to membrane0.90840.4548InformativeInherited
Cellular Component (CC)intrinsic to plasma membrane0.34370.02894InformativeInherited
Cellular Component (CC)ion channel complex0.000021430.000000001182Highly InformativeDirect
Cellular Component (CC)integral to plasma membrane0.2890.01539Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000002104 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5798 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000151 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000257 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0001786 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.000004866 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00002454 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2641 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.593 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8146 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.194 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3252 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9564 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.07733 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6209 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4702 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.9068 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.5807 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2418 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.05696 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9089 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2086 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1918 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.08796 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) peptide metabolic process 0.000001421 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.00009309 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.0000006932 Informative Direct
Biological Process (BP) vitamin metabolic process 0.00005947 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000001055 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000005538 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0001877 Informative Direct
Biological Process (BP) secondary metabolic process 0.00008663 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00000000000146 Informative Direct
Biological Process (BP) amide biosynthetic process 0.00000005854 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000002452 Informative Direct
Biological Process (BP) single-organism behavior 0.0004286 Informative Direct
Biological Process (BP) protein oligomerization 0.0000002629 Informative Direct
Biological Process (BP) metal ion transport 0.005503 Informative Inherited
Biological Process (BP) transmembrane transport 0.1295 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2904 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1859 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4655 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.06558 Informative Inherited
Biological Process (BP) response to lipid 0.1863 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.003579 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7946 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.5011 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.04797 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1302 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.04743 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.01247 Informative Inherited
Biological Process (BP) lipid catabolic process 0.001437 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.001041 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.5651 Informative Inherited
Biological Process (BP) protein transport 0.7816 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.5888 Informative Inherited
Biological Process (BP) protein localization to organelle 0.3015 Informative Inherited
Biological Process (BP) retinoid metabolic process 0.000000000004268 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0.00001138 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.00001122 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00000001919 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0000006138 Highly Informative Direct
Biological Process (BP) digestion 0.00000001497 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000522 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.000008337 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.0001934 Highly Informative Direct
Biological Process (BP) adult behavior 0.000008222 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0.00000004926 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.0004171 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.00005059 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.000000000001017 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000000007118 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0.0002917 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.00000000001138 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0001735 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.000002731 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000007766 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.000001375 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.00000675 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.00000007424 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.0001772 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.000489 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.0008052 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.08979 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.006829 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.04642 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.00393 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.002864 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.1772 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1606 Highly Informative Inherited
Biological Process (BP) protein import 0.01068 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.007045 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.002364 Highly Informative Inherited
Biological Process (BP) nuclear import 0.00267 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5217 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.7492 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.0002117 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.7055 Informative Inherited
Molecular Function (MF) cofactor binding 0.0327 Informative Inherited
Molecular Function (MF) enzyme binding 0.09734 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.005528 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.3665 Informative Inherited
Molecular Function (MF) lipid binding 0.01903 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.02352 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.002775 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cation channel activity 0.0005575 Highly Informative Direct
Molecular Function (MF) steroid binding 0.000002081 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.00000000000519 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.00005768 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.000792 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.00003291 Highly Informative Direct
Molecular Function (MF) NADP binding 0.00001208 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.1304 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 0.1024 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.5961 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5601 Least Informative Inherited
Cellular Component (CC) cytosol 0.0000008566 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.5899 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0.4548 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.02894 Informative Inherited
Cellular Component (CC) ion channel complex 0.000000001182 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.01539 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.4925Moderately InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000067InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.007424Least InformativeInherited
Drugbank ATC_code (DB)drugs used in diabetes0.002682Moderately InformativeInherited
Drugbank ATC_code (DB)other drugs used in diabetes0.0000000182Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCarbohydrate metabolism0.00000000000118Moderately InformativeDirect
Biological processIon transport0.0000983Moderately InformativeDirect
Biological processLipid metabolism0.0001604Moderately InformativeDirect
Biological processSteroid metabolism0.0000000003171InformativeDirect
Biological processFatty acid metabolism0.5437InformativeInherited
Biological processPotassium transport0Highly InformativeDirect
Biological processProstaglandin biosynthesis0.0000000000003372Highly InformativeDirect
Molecular functionNAD0.00000000935Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0.00000000001482InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIon channel0.00000000000005256InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationAcetylation0.000000002841Least InformativeDirect
Post-translational modificationS-nitrosylation0.0000007541InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.00000001781Least InformativeDirect
UniPathway (UP)lipid metabolism0.5456Least InformativeInherited
UniPathway (UP)cofactor metabolism0.9176Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.000000000003301Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.000004272Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0.0000151Moderately InformativeDirect
UniPathway (UP)energy metabolism0.0001668Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.004078Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.261Moderately InformativeInherited
UniPathway (UP)alkaloid metabolism0.00000000000001708InformativeDirect
UniPathway (UP)toxin biosynthesis0.000000000001179InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.000607InformativeDirect
UniPathway (UP)polyketide biosynthesis0.05611InformativeInherited
UniPathway (UP)prostaglandin biosynthesis0.0000000000000236Highly InformativeDirect
UniPathway (UP)oligopeptide biosynthesis0.000000001316Highly InformativeDirect
UniPathway (UP)isoquinoline alkaloid biosynthesis0.001366Highly InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0.4219Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001395 SSF51430 Protein matches
Abstract

The aldo-keto reductase family includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase, xylose reductase, rho crystallin, and many others [PubMed2498333]. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide binding proteins [PubMed2105951]. The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. The hydrophobic nature of the pocket favours aromatic and apolar substrates over highly polar ones [PubMed1621098].

Binding of the NADPH coenzyme causes a massive conformational change, reorienting a loop, effectively locking the coenzyme in place. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases [PubMed1447221].

Some proteins of this entry contain a K+ ion channel beta chain regulatory domain; these are reported to have oxidoreductase activity [PubMed10884227].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-linked oxidoreductase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the NAD(P)-linked oxidoreductase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]