SUPERFAMILY 1.75 HMM library and genome assignments server

dUTPase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-clip [ 51268] (7)
Superfamily:   dUTPase-like [ 51283]
Families:   dUTPase-like [ 51284] (4)


Superfamily statistics
Genomes (2,937) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,650 26,799 16
Proteins 5,479 26,021 15


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00000022940.000001016Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.0000045720.00001095Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00000021430.0000007974Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000007740.00000283Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0058910.001176Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.000005230.0000662Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.0000010810.000001028Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0000029060.0000002595Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000031890.000001797Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.014160.00992Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.031560.01821Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.0000000000033240.00000000001129InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00025620.0001577InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.000000002640.00000000000005424InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.0036520.005497InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.03060.0149InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.014930.01438InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process00.000000000003351Highly InformativeDirect
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process00Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process00.000000000000001938Highly InformativeDirect
Biological Process (BP)deoxyribose phosphate metabolic process0.000000000000011040Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound catabolic process0.0000021310.00000002044Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000013730.0000000002238Least InformativeDirect
Molecular Function (MF)nucleoside-triphosphate diphosphatase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000001016 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00001095 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000007974 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000283 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.001176 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0000662 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000001028 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000002595 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000001797 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00992 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.01821 Moderately Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.00000000001129 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0001577 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0.00000000000005424 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.005497 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.0149 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01438 Informative Inherited
Biological Process (BP) pyrimidine nucleotide metabolic process 0.000000000003351 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0.000000000000001938 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound catabolic process 0.00000002044 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000000002238 Least Informative Direct
Molecular Function (MF) nucleoside-triphosphate diphosphatase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0.09958Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000001499InformativeDirect
Enzyme Commission (EC)dUTP diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.0000000009013InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0.0755InformativeInherited
Enzyme Commission (EC)Exoribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.000000000007192Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirus entry into host cell0.0005282InformativeDirect
Biological processNucleotide metabolism0Highly InformativeDirect
Biological processViral genome integration0Highly InformativeDirect
Biological processDNA integration0.000000008782Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationAspartyl protease0Highly InformativeDirect
Post-translational modificationRNA-directed DNA polymerase4.449e-16Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a dUTPase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the dUTPase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]