SUPERFAMILY 1.75 HMM library and genome assignments server

Clathrin heavy-chain terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Clathrin heavy-chain terminal domain [ 50989]
Families:   Clathrin heavy-chain terminal domain [ 50990]

Superfamily statistics
Genomes (481) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 780 817 5
Proteins 770 815 5

Functional annotation
General category Metabolism
Detailed category Energy

Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000006319 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.4099 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01488 Least Informative Inherited
Biological Process (BP) organelle organization 0.0004204 Moderately Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000000002558 Informative Direct
Cellular Component (CC) membrane 0.000000000004814 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000002827 Least Informative Direct
Cellular Component (CC) protein complex 0.0000000000001136 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00009347 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.3617 Least Informative Inherited
Cellular Component (CC) vesicle 0.0004592 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.00133 Moderately Informative Inherited
Cellular Component (CC) coated vesicle 0.0000000000008556 Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.00000000000008845 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationAcetylation0.000009714Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001473 SSF50989 Protein matches

This entry represents the N-terminal beta-propeller region of clathrin heavy chains that extends away from the hub of triskelia, and which are responsible for peptide binding [PubMed9827808].

More information about these proteins can be found at Protein of the Month: Clathrin.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Clathrin heavy-chain terminal domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Clathrin heavy-chain terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]