RCC1/BLIP-II superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (174)
Fold:	7-bladed beta-propeller [ 50964] (14)
Superfamily:	RCC1/BLIP-II [ 50985] (2)
Families:	Regulator of chromosome condensation RCC1 [ 50986]
	beta-lactamase inhibitor protein-II, BLIP-II [ 69315]

Superfamily statistics

	Genomes (680)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	9,215	8,866	3
Proteins	7,608	7,154	3

Functional annotation

General category	Processes_IC
Detailed category	Cell cycle, Apoptosis

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Molecular Function (MF)	enzyme regulator activity	0.003726	7.924e-10	Moderately Informative	Inherited
Molecular Function (MF)	GTPase regulator activity	1.087e-05	4.552e-15	Informative	Direct
Molecular Function (MF)	guanyl-nucleotide exchange factor activity	1.031e-06	0	Highly Informative	Direct
Molecular Function (MF)	small GTPase regulator activity	3.53e-07	0.006113	Highly Informative	Inherited
Cellular Component (CC)	membrane	0.1044	1	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	0.3374	0.1761	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	0.3197	0.9962	Least Informative	Inherited
Cellular Component (CC)	endomembrane system	0.0002281	0.1572	Moderately Informative	Inherited
Cellular Component (CC)	organelle membrane	0.005787	0.2558	Moderately Informative	Inherited
Cellular Component (CC)	organelle envelope	0.001543	0.05852	Moderately Informative	Inherited
Cellular Component (CC)	nuclear part	0.01805	0.4234	Moderately Informative	Inherited
Cellular Component (CC)	nuclear envelope	1.132e-06	0.001401	Informative	Inherited
Cellular Component (CC)	nuclear membrane	5.888e-09	6.895e-06	Highly Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	protein metabolic process	0.8018	Least Informative	Inherited
Biological Process (BP)	cellular macromolecule metabolic process	0.8278	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	0.4234	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	0.1852	Least Informative	Inherited
Biological Process (BP)	developmental process	0.164	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	0.009818	Least Informative	Inherited
Biological Process (BP)	anatomical structure morphogenesis	0.0001437	Moderately Informative	Direct
Biological Process (BP)	cellular protein modification process	0.3041	Moderately Informative	Inherited
Biological Process (BP)	cell differentiation	1	Moderately Informative	Inherited
Biological Process (BP)	nervous system development	0.001819	Moderately Informative	Inherited
Biological Process (BP)	system process	0.001172	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	0.1086	Moderately Informative	Inherited
Biological Process (BP)	organ development	0.6677	Moderately Informative	Inherited
Biological Process (BP)	cell projection organization	1.706e-05	Informative	Direct
Biological Process (BP)	generation of neurons	8.03e-06	Informative	Direct
Biological Process (BP)	protein modification by small protein conjugation or removal	0.0004471	Informative	Direct
Biological Process (BP)	sensory organ development	0.004493	Informative	Inherited
Biological Process (BP)	organ morphogenesis	0.00824	Informative	Inherited
Biological Process (BP)	cellular component morphogenesis	0.007618	Informative	Inherited
Biological Process (BP)	protein ubiquitination	2.43e-05	Highly Informative	Direct
Biological Process (BP)	eye morphogenesis	0.0001479	Highly Informative	Direct
Biological Process (BP)	photoreceptor cell differentiation	0.001358	Highly Informative	Inherited
Biological Process (BP)	sensory perception	0.02232	Highly Informative	Inherited
Molecular Function (MF)	binding	0.9559	Least Informative	Inherited
Molecular Function (MF)	enzyme regulator activity	7.924e-10	Moderately Informative	Direct
Molecular Function (MF)	protein binding	0.3266	Moderately Informative	Inherited
Molecular Function (MF)	ligase activity, forming carbon-nitrogen bonds	8.166e-07	Informative	Direct
Molecular Function (MF)	enzyme binding	7.361e-06	Informative	Direct
Molecular Function (MF)	GTPase regulator activity	4.552e-15	Informative	Direct
Molecular Function (MF)	protein dimerization activity	3.56e-06	Informative	Direct
Molecular Function (MF)	guanyl-nucleotide exchange factor activity	0	Highly Informative	Direct
Molecular Function (MF)	small conjugating protein ligase activity	5.651e-08	Highly Informative	Direct
Molecular Function (MF)	protein kinase regulator activity	1.135e-05	Highly Informative	Direct
Molecular Function (MF)	protein homodimerization activity	4.03e-08	Highly Informative	Direct
Molecular Function (MF)	small GTPase regulator activity	0.006113	Highly Informative	Inherited
Cellular Component (CC)	membrane	1	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	0.9962	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	0.1761	Least Informative	Inherited
Cellular Component (CC)	cell projection	6.907e-08	Moderately Informative	Direct
Cellular Component (CC)	endomembrane system	0.1572	Moderately Informative	Inherited
Cellular Component (CC)	organelle membrane	0.2558	Moderately Informative	Inherited
Cellular Component (CC)	organelle envelope	0.05852	Moderately Informative	Inherited
Cellular Component (CC)	nuclear part	0.4234	Moderately Informative	Inherited
Cellular Component (CC)	nuclear envelope	0.001401	Informative	Inherited
Cellular Component (CC)	nuclear membrane	6.895e-06	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	Moderately Informative	Direct

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head and neck	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the integument	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Cognitive impairment	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of pyramidal motor function	0	Informative	Direct

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organ system	0	Least Informative	Direct
Fly Anatomy (FA)	cell	0	Least Informative	Direct
Fly Anatomy (FA)	organ system subdivision	0	Least Informative	Direct

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	male genitalia	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	gonad	0	Least Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	Least Informative	Direct
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Cell cycle	3.699e-14	Moderately Informative	Direct
Biological process	Mitosis	0	Informative	Direct
Biological process	Ubl conjugation pathway	0	Informative	Direct
Cellular component	Nucleus	0	Least Informative	Direct
Cellular component	Cytoplasm	0.1898	Least Informative	Inherited
Cellular component	Cytoskeleton	1.008e-07	Moderately Informative	Direct
Cellular component	Cell projection	6.807e-06	Moderately Informative	Direct
Cellular component	Cilium	5.824e-09	Highly Informative	Direct
Domain	Repeat	0	Least Informative	Direct
Molecular function	Metal-binding	1	Least Informative	Inherited
Molecular function	Zinc-finger	8.3e-05	Moderately Informative	Direct
Post-translational modification	Transferase	1	Least Informative	Inherited
Post-translational modification	Ligase	1.475e-06	Moderately Informative	Direct
Post-translational modification	Kinase	6.956e-05	Moderately Informative	Direct
Post-translational modification	Receptor	0.0002115	Moderately Informative	Direct
Post-translational modification	Guanine-nucleotide releasing factor	0	Informative	Direct
Post-translational modification	Serine/threonine-protein kinase	5.81e-13	Informative	Direct
Post-translational modification	Phosphoprotein	6.047e-07	Least Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	biopolymer metabolism	0	Least Informative	Direct
UniPathway (UP)	protein ubiquitination	0	Moderately Informative	Direct

Document: UP annotation of SCOP domains

InterPro annotation

Cross references IPR009091 SSF50985 Protein matches

Abstract
The beta-lactamase-inhibitor protein II (BLIP-II) is a secreted protein produced by the soil bacteria Streptomyces exfoliates SMF19. BLIP-II acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP-II binds competitively to TEM-1, but no direct contacts are made with TEM-1 active site residues. BLIP-II shows no sequence similarity with BLIP, even though both bind to and inhibit TEM-1. However, BLIP-II does share significant sequence identity with the regulator of chromosome condensation (RCC1) family of proteins. These two families are clearly related, both having a seven-bladed beta-propeller structure, although they differ in the number of strands per blade, BLIP-II having three antiparallel beta-strands per blade, while RCC1 has four-stranded blades [ PubMed 11573088]. RCC1 is a eukaryotic nuclear protein that acts as a guanine nucleotide exchange factor for Ran, a member of the Ras GTPase family. RCC1 mediates a Ran-GTP gradient necessary for the regulation of spindle formation and nuclear assembly during mitosis, as well as for the transport of macromolecules across the nuclear membrane during interphase.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a RCC1/BLIP-II domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the RCC1/BLIP-II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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RCC1/BLIP-II superfamily