SUPERFAMILY 1.75 HMM library and genome assignments server

Sialidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Sialidases [ 50939] (2)
Families:   Sialidases (neuraminidases) [ 50940] (9)
  Endo-alpha-sialidase [ 117276]


Superfamily statistics
Genomes (1,242) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,720 66,574 43
Proteins 3,302 65,974 43


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.0033220.1242Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.017460.1626Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000068950.0000244Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.0000000081470.0000001305Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000000019890.000000764Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0000056880.0001719Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.0038730.01257Moderately InformativeInherited
Biological Process (BP)membrane lipid metabolic process00InformativeDirect
Biological Process (BP)lipid catabolic process0.00000092970.000000006981InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.0000011070.000000005954InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.00080460.0002963InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process0.0060840.001357InformativeInherited
Biological Process (BP)ceramide metabolic process0.000028620.00000469Highly InformativeDirect
Biological Process (BP)glycosphingolipid metabolic process00Highly InformativeDirect
Biological Process (BP)oligosaccharide metabolic process00Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.00000000000068810.000001923Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.32590.5881Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.041040.05821Least InformativeInherited
Cellular Component (CC)lytic vacuole0.0000013420.0000001656InformativeDirect
Cellular Component (CC)lysosome0.00000072220.00000004671Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.1242 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3497 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.7136 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7382 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9837 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8933 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1626 Least Informative Inherited
Biological Process (BP) localization 0.03721 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.8336 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9829 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000244 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0000001305 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0002468 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0005936 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0004289 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000764 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0001719 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0471 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.009257 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.08135 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.001399 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.002303 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0369 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.002739 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.009936 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01257 Moderately Informative Inherited
Biological Process (BP) organ development 0.3957 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.03827 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.06098 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00003183 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) central nervous system development 0.000217 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0009812 Informative Direct
Biological Process (BP) lipid catabolic process 0.000000006981 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000000005954 Informative Direct
Biological Process (BP) phosphorylation 0.0004095 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000006584 Informative Direct
Biological Process (BP) cell projection organization 0.000001299 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00001055 Informative Direct
Biological Process (BP) locomotion 0.0009846 Informative Direct
Biological Process (BP) regulation of kinase activity 0.000003849 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000007194 Informative Direct
Biological Process (BP) generation of neurons 0.000005364 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.00004178 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002963 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.001357 Informative Inherited
Biological Process (BP) cellular component movement 0.001258 Informative Inherited
Biological Process (BP) localization of cell 0.001224 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000001626 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000806 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00000469 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00001054 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00002692 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.000000004842 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000000000868 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00000006841 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.0000001085 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0000001134 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000001923 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.5881 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.05821 Least Informative Inherited
Cellular Component (CC) cell projection 0.000464 Moderately Informative Direct
Cellular Component (CC) lytic vacuole 0.0000001656 Informative Direct
Cellular Component (CC) neuron projection 0.0000004226 Informative Direct
Cellular Component (CC) lysosome 0.00000004671 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.00002366Least InformativeDirect
Drugbank ATC_code (DB)antivirals for systemic use0.0000000006587InformativeDirect
Drugbank ATC_code (DB)neuraminidase inhibitors0.00000000000006556Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8131Least InformativeInherited
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processProtein transport0.0000000004865Moderately InformativeDirect
Biological processCarbohydrate metabolism0.0000013Moderately InformativeDirect
Biological processLipid metabolism0.001342Moderately InformativeInherited
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid degradation0.00000000000008378Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0.00000000008889Moderately InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentLysosome0.0000596InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationReceptor0.0000003436Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011040 SSF50939 Protein matches
Abstract

Neuraminidases (sialidases) hydrolyse the non-reducing, terminal sialic acid linkage in various natural substrates, such as glycoproteins, glycolipids, gangliosides, and polysaccharides [PubMed12374200]. In mammals, neuraminidases occur in the lysosome, the cytosol, and associated with the plasma membrane. Neuraminidases have also been implicated in the pathogenesis of many diseases. For example, in viruses neuraminidases enable the transport of the virus through mucin, the eruption of the virus from the infected host cell, and the prevention of self-aggregation of virus particles through the destruction of the host cell receptor recognised by the virus [PubMed14561719]. Eukaryotic, bacterial and viral neuraminidases share highly conserved regions of beta-sheet motifs. Bacterial neuraminidases often possess domains in addition to the catalytic neuraminidase domain, for instance the neuraminidase from Micromonospora viridifaciens contains three domains, of which the catalytic domain described here is the N-terminal domain [PubMed8591030]. Similarly, leech neuraminidase is a multidomain protein, where the catalytic domain is the C-terminal domain [PubMed9878409]. In several paramyxoviruses, neuraminidase forms part of the multi-functional haemagglutinin-neuraminidase glycoprotein found on the viral envelope [PubMed14729348].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Yeast Phenotype (YP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sialidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Sialidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Yeast Phenotype (YP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]