This entry represents an actin-crosslinking domain with a beta-trefoil structure, consisting of a triplet of beta-hairpins packed against a six-stranded antiparallel beta-barrel. Proteins containing this domain include fascin, which carries a tandem repeat of four copies of this domain, and the histidine-rich actin-binding protein hisactophilin. Actin-crosslinking proteins organise actin filaments into dynamic and complex subcellular scaffolds that orchestrate important mechanical functions, including cell motility and adhesion .
The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles .
A related protein, hisactophilin, is an essential protein for the osmoprotection of dictyostelium cells [11847289, 11996675].