SUPERFAMILY 1.75 HMM library and genome assignments server


SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (623) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 35,789 33,378 127
Proteins 27,872 25,865 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.51831Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0017221.093e-07Least InformativeInherited
Biological Process (BP)response to stimulus0.0076470Least InformativeInherited
Biological Process (BP)single-organism cellular process0.024820Least InformativeInherited
Biological Process (BP)developmental process0.0037280Least InformativeInherited
Biological Process (BP)signal transduction0.00077260Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process0.3431Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.033320Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.021610.004696Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.032370.583Moderately InformativeInherited
Biological Process (BP)tissue development0.013630.01986Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.064641.263e-09Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.10785.506e-09Moderately InformativeInherited
Biological Process (BP)biological adhesion4.433e-073.638e-06InformativeDirect
Biological Process (BP)positive regulation of phosphorus metabolic process2.624e-052.555e-05InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00075530InformativeDirect
Biological Process (BP)regulation of organelle organization5.215e-050.2152InformativeInherited
Biological Process (BP)tissue morphogenesis0.0022825.277e-06InformativeInherited
Biological Process (BP)epithelium development0.13740.04671InformativeInherited
Biological Process (BP)regulation of actin cytoskeleton organization1.007e-060Highly InformativeDirect
Cellular Component (CC)vesicle0.00062190Moderately InformativeDirect
Cellular Component (CC)cell projection0.00091670Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.093e-07 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 8.088e-12 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 2.012e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.263e-09 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 5.506e-09 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.369e-09 Moderately Informative Direct
Biological Process (BP) system process 1.771e-06 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.00148 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3716 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6631 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.00104 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1047 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5708 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.005647 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03119 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.7469 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.002069 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1938 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.004696 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.0768 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.9043 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.583 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01986 Moderately Informative Inherited
Biological Process (BP) reproduction 0.818 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.0142 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.7661 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.04097 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3307 Moderately Informative Inherited
Biological Process (BP) biological adhesion 3.638e-06 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 2.555e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 6.127e-06 Informative Direct
Biological Process (BP) tissue morphogenesis 5.277e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0002736 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) protein phosphorylation 1.119e-13 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.132e-12 Informative Direct
Biological Process (BP) cell activation 6.265e-12 Informative Direct
Biological Process (BP) cellular component movement 3.517e-10 Informative Direct
Biological Process (BP) localization of cell 6.062e-10 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.286e-09 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.123e-08 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 2.854e-08 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 4.282e-08 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 7.223e-08 Informative Direct
Biological Process (BP) positive regulation of immune system process 1.059e-06 Informative Direct
Biological Process (BP) cellular membrane organization 1.092e-06 Informative Direct
Biological Process (BP) generation of neurons 6.131e-06 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 6.439e-06 Informative Direct
Biological Process (BP) regulation of locomotion 7.24e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.963e-05 Informative Direct
Biological Process (BP) immune response 2.238e-05 Informative Direct
Biological Process (BP) regulation of nervous system development 4.458e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 9.13e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001748 Informative Direct
Biological Process (BP) response to organic nitrogen 0.0003535 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0003754 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0004813 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0008633 Informative Direct
Biological Process (BP) regulation of organelle organization 0.2152 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001883 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6936 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.791 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001593 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 1 Informative Inherited
Biological Process (BP) epithelium development 0.04671 Informative Inherited
Biological Process (BP) defense response 0.002802 Informative Inherited
Biological Process (BP) response to other organism 0.9563 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) metal ion transport 0.003581 Informative Inherited
Biological Process (BP) regulation of cell development 0.01582 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.4262 Informative Inherited
Biological Process (BP) sensory organ development 0.1777 Informative Inherited
Biological Process (BP) cell proliferation 0.3324 Informative Inherited
Biological Process (BP) muscle structure development 0.0113 Informative Inherited
Biological Process (BP) cardiovascular system development 0.6065 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.01099 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of system process 0.9898 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.3602 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.6396 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1923 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.2421 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) response to wounding 0.002005 Informative Inherited
Biological Process (BP) tube development 0.2873 Informative Inherited
Biological Process (BP) regulation of immune response 0.1444 Informative Inherited
Biological Process (BP) single-organism behavior 0.2159 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) immune effector process 0.001351 Informative Inherited
Biological Process (BP) growth 0.1715 Informative Inherited
Biological Process (BP) regulation of ion transport 0.8492 Informative Inherited
Biological Process (BP) positive regulation of transport 0.03066 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6426 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.001524 Informative Inherited
Biological Process (BP) muscle system process 0.9333 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of growth 0.2787 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.5411 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.2006 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2424 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1765 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.001382 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1398 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.006226 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.8954 Informative Inherited
Biological Process (BP) protein transport 0.05474 Informative Inherited
Biological Process (BP) pigment metabolic process 0.03795 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 0 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) phagocytosis 2.076e-15 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 4.008e-15 Highly Informative Direct
Biological Process (BP) calcium ion transport 8.846e-14 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 7.199e-13 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 2.861e-11 Highly Informative Direct
Biological Process (BP) activation of immune response 2.304e-10 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 8.762e-10 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 2.995e-09 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 3.574e-09 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 4.283e-09 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 7.435e-09 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 9.536e-09 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.934e-08 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 1.077e-07 Highly Informative Direct
Biological Process (BP) synaptic vesicle transport 2.032e-07 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 3.222e-07 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 1.033e-06 Highly Informative Direct
Biological Process (BP) response to ethanol 1.059e-06 Highly Informative Direct
Biological Process (BP) cell projection assembly 6.33e-06 Highly Informative Direct
Biological Process (BP) chemotaxis 8.575e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 4.238e-05 Highly Informative Direct
Biological Process (BP) T cell activation 6.555e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 8.415e-05 Highly Informative Direct
Biological Process (BP) hemostasis 8.845e-05 Highly Informative Direct
Biological Process (BP) wound healing 0.0003838 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.000391 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000463 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0005896 Highly Informative Direct
Biological Process (BP) response to acid 0.0006865 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0006943 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0009168 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.007771 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.4993 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 1 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.007224 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.6898 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.02235 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.1278 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.09351 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.6282 Highly Informative Inherited
Biological Process (BP) inner ear development 0.1532 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.3356 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.8783 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 1 Highly Informative Inherited
Biological Process (BP) kidney development 0.1306 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.09238 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.07384 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.0563 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.856 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.6571 Highly Informative Inherited
Biological Process (BP) muscle fiber development 1 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2045 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.01309 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.876 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.1443 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 1 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.5734 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.4906 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.2564 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.2743 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.9865 Highly Informative Inherited
Biological Process (BP) epidermis development 1 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.9298 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.6514 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.23 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7595 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.001829 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.1578 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.6624 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.2132 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.001662 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.5426 Highly Informative Inherited
Biological Process (BP) protein import 0.4561 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3803 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02585 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.08537 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.004392 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.02961 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.007792 Highly Informative Inherited
Biological Process (BP) cell division 0.002993 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.1033 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.0177 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.7965 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.4883 Highly Informative Inherited
Biological Process (BP) response to fungus 0.2328 Highly Informative Inherited
Biological Process (BP) lymphocyte differentiation 0.04504 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 4.183e-07 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 2.333e-15 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 7.312e-08 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001963 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 2.51e-09 Informative Direct
Molecular Function (MF) lipid binding 1.771e-07 Informative Direct
Molecular Function (MF) enzyme binding 4.756e-07 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 4.324e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.001129 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.2681 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.08789 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8546 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4816 Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 3.265e-06 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 3.607e-05 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.0001215 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.0001922 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002667 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0006044 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0006316 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.004225 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.3508 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.03233 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.626e-06 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1382 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.001148 Moderately Informative Inherited
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 2.904e-13 Informative Direct
Cellular Component (CC) contractile fiber part 3.57e-09 Informative Direct
Cellular Component (CC) microbody 0.3781 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.1697 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nonmotile primary cilium 1.881e-13 Highly Informative Direct
Cellular Component (CC) synaptic membrane 5.05e-10 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 6.204e-10 Highly Informative Direct
Cellular Component (CC) ruffle 4.924e-07 Highly Informative Direct
Cellular Component (CC) membrane raft 2.089e-05 Highly Informative Direct
Cellular Component (CC) microbody membrane 3.655e-05 Highly Informative Direct
Cellular Component (CC) cell division site part 3.891e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 4.791e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 8.067e-05 Highly Informative Direct
Cellular Component (CC) cilium part 0.0001222 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.000185 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.0007599 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000822 Highly Informative Direct
Cellular Component (CC) microbody part 0.00321 Highly Informative Inherited
Cellular Component (CC) axon part 0.8141 Highly Informative Inherited
Cellular Component (CC) dendrite 0.04582 Highly Informative Inherited
Cellular Component (CC) internal side of plasma membrane 0.1572 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.2023 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.005325 Highly Informative Inherited
Cellular Component (CC) myosin complex 0.0753 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases6.272e-08Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C3.251e-15InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase2.472e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.6294Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.7892Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.841Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.3692Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5466Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.5622Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.8466Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.9699Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent bacterial infections0.0996InformativeInherited
Phenotypic Abnormality (PA)Cellulitis1.576e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Liver abscess3.53e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Obstructive lung disease0.0001821Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0005461Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.09282Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.006381Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02607Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1047Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0002534Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.000284Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.001601Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.001917Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.002183Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.002769Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.08266Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.113Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.1596InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.169InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.2101InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.2573InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4647InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.8017InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling7.81e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.004727Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus layer morphology0.02262Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.1331Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0252Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001466Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.5969Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000381InformativeDirect
Worm Phenotype (WP)protein expression variant0.0009601InformativeDirect
Worm Phenotype (WP)endomitotic oocytes9.373e-06Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001518Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.06832Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport1.992e-05InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.206InformativeInherited
Yeast Phenotype (YP)endocytosis3.713e-07Highly InformativeDirect
Yeast Phenotype (YP)chitin deposition0.0002023Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)animal pole0.0009124Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0003326Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases7.608e-08InformativeDirect
Enzyme Commission (EC)Hexosyltransferases7.963e-05InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C3.524e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8753Least InformativeInherited
Biological processProtein transport7.571e-13Moderately InformativeDirect
Biological processApoptosis2.774e-10Moderately InformativeDirect
Biological processDifferentiation1.05e-06Moderately InformativeDirect
Biological processCell cycle0.04548Moderately InformativeInherited
Biological processIon transport0.5186Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processNeurogenesis1.801e-11InformativeDirect
Biological processCell adhesion3.019e-11InformativeDirect
Biological processInflammatory response0.0002386InformativeDirect
Biological processMitosis0.0007503InformativeDirect
Biological processPhagocytosis1.148e-15Highly InformativeDirect
Biological processAdaptive immunity1.096e-14Highly InformativeDirect
Biological processVoltage-gated channel1.383e-13Highly InformativeDirect
Biological processCilium biogenesis/degradation3.513e-12Highly InformativeDirect
Biological processExocytosis3.168e-07Highly InformativeDirect
Biological processAutophagy0.0001398Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell membrane5.252e-07Moderately InformativeDirect
Cellular componentPostsynaptic cell membrane2.758e-14InformativeDirect
Cellular componentLysosome1.058e-06InformativeDirect
Cellular componentCoated pit6.395e-16Highly InformativeDirect
Cellular componentTight junction0.0008201Highly InformativeDirect
Coding sequence diversityAlternative splicing1.976e-10Least InformativeDirect
Coding sequence diversityChromosomal rearrangement7.221e-05InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainANK repeat6.766e-08InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionZinc1Least InformativeInherited
Molecular functionCalcium3.056e-07Moderately InformativeDirect
Molecular functionZinc-finger0.0006532Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Molecular functionCalcium channel0Highly InformativeDirect
Molecular functionCalcium transport2.52e-13Highly InformativeDirect
Molecular functionLIM domain8.84e-08Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.731e-07Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel9.296e-07InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping8.681e-09Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation4.47e-06Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation2.418e-05InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001452 SSF50044 Protein matches
Abstract SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [PubMed15335710, PubMed11256992]. They are found in a great variety of intracellular or membrane-associated proteins [PubMed1639195, PubMed14731533, PubMed7531822] for example, in a variety of proteins with enzymatic activity, in adaptor proteins that lack catalytic sequences and in cytoskeletal proteins, such as fodrin and yeast actin binding protein ABP-1.

The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH2-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [PubMed7953536].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH3-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the SH3-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]