SUPERFAMILY 1.75 HMM library and genome assignments server

Osmotin, thaumatin-like protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Osmotin, thaumatin-like protein [ 49869]
Superfamily:   Osmotin, thaumatin-like protein [ 49870]
Families:   Osmotin, thaumatin-like protein [ 49871] (4)

Superfamily statistics
Genomes (247) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,979 2,709 7
Proteins 2,925 2,684 7

Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.031570.1944Least InformativeInherited
Biological Process (BP)multi-organism process0.001140.0005071Moderately InformativeInherited
Biological Process (BP)defense response0.00000053580.000004043InformativeDirect
Cellular Component (CC)external encapsulating structure0.0000039260.000001255InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.1944 Least Informative Inherited
Biological Process (BP) multi-organism process 0.0005071 Moderately Informative Direct
Biological Process (BP) defense response 0.000004043 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000001255 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01393Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.08557Least InformativeInherited
Worm Phenotype (WP)metal response variant0.0000006754InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.00004447InformativeDirect

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPlant defense0InformativeDirect
Biological processStress response0.00005086InformativeDirect
Cellular componentSecreted0.00000000002112Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationDisulfide bond0.000000000000004868Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001938 SSF49870 Protein matches

Pathogenesis related (PR) proteins, which are induced by various agents ranging from ethylene to pathogens, are structurally diverse and apparently ubiquitous in plants [PubMed1463856]: they include thaumatin, osmotin, tobacco major and minor PR proteins, alpha-amylase/trypsin inhibitor, and P21 and PWIR2 soybean and wheat leaf proteins. The proteins are involved in systematically acquired resistance and stress response in plants, although their precise role is unknown [PubMed1463856]. Thaumatin is an intensely sweet tasting protein (about 100,000 times sweeter than sucrose [PubMed7049841]) found in the West African shrub Thaumatococcus daniellii: it is induced by attack by viroids, which are single-stranded unencapsulated RNA molecules that do not code for protein.

Like other PR proteins, thaumatin is predicted to have a mainly beta structure, with a high content of beta-turns and little helix [PubMed1463856]. Tobacco cells exposed to gradually increased salt concentrations develop a greatly increased tolerance to salt, due to the expression of osmotin, a member of the PR protein family. Wheat plants attacked by barley powdery mildew express a PR protein (PWIR2), which results in resistance against that infection [PubMed1650615]. The similarity between this and other PR proteins to the maize alpha-amylase/trypsin inhibitor has suggested that PR proteins may act as some form of inhibitor [PubMed1650615].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Osmotin, thaumatin-like protein domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Osmotin, thaumatin-like protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]