gamma-Crystallin-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (174)
Fold:	gamma-Crystallin-like [ 49694]
Superfamily:	gamma-Crystallin-like [ 49695] (6)
Families:	Crystallins/Ca-binding development proteins [ 49696] (4)
	Yeast killer toxin [ 49710]
	Streptomyces metalloproteinase inhibitor, SMPI [ 49713]
	Killer toxin-like protein SKLP [ 49716]
	Antifungal protein AFP1 [ 63693]
	Plant antimicrobial protein MIAMP1 [ 49719]

Superfamily statistics

	Genomes (216)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	2,284	2,943	29
Proteins	1,801	2,342	28

Functional annotation

General category	General
Detailed category	Structural protein

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	0.04331	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	0.002521	Least Informative	Inherited
Biological Process (BP)	single-organism developmental process	0.000756	Moderately Informative	Direct
Biological Process (BP)	organ development	4.712e-07	Moderately Informative	Direct
Biological Process (BP)	tissue development	0.9274	Moderately Informative	Inherited
Biological Process (BP)	cell differentiation	1	Moderately Informative	Inherited
Biological Process (BP)	system process	0.2168	Moderately Informative	Inherited
Biological Process (BP)	sensory organ development	0	Informative	Direct
Biological Process (BP)	epithelium development	0.0251	Informative	Inherited
Biological Process (BP)	sensory perception	2.209e-07	Highly Informative	Direct
Molecular Function (MF)	structural molecule activity	0	Moderately Informative	Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	nervous system disease	0.0001556	Least Informative	Direct
Disease Ontology (DO)	sensory system disease	3.004e-08	Moderately Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the anterior segment of the eye	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the lens	0	Informative	Direct
Phenotypic Abnormality (PA)	Zonular cataract	0	Highly Informative	Direct

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal eye morphology	0	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal anterior eye segment morphology	0	Informative	Direct
Mammalian Phenotype (MP)	abnormal lens morphology	0	Highly Informative	Direct
Mammalian Phenotype (MP)	microphthalmia	9.114e-07	Highly Informative	Direct

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	central nervous system	0.8157	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.1397	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	sensory system	0.4218	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	lens	3.701e-08	Highly Informative	Direct
Xenopus DEvelopment stage (XDE)	embryonic stage	0	Least Informative	Direct
Xenopus DEvelopment stage (XDE)	tailbud stage	0.0004074	Moderately Informative	Direct

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Disease	Cataract	0	Highly Informative	Direct
Domain	Repeat	0	Least Informative	Direct
Post-translational modification	Eye lens protein	0	Highly Informative	Direct
Post-translational modification	Acetylation	4.945e-14	Moderately Informative	Direct
Post-translational modification	Methylation	5.703e-07	Moderately Informative	Direct
Post-translational modification	Oxidation	0	Highly Informative	Direct

Document: KW annotation of SCOP domains

InterPro annotation

Cross references IPR011024 SSF49695 Protein matches

Abstract
This family contains proteins which have a Greek key motif [ PubMed 8506258]. They are all structurally related to the beta/gamma crystallin superfamily. This family of proteins includes:

Beta and gamma crystallins

Yeast killer toxin

Killer toxin-like protein SKLP

Antifungal protein, AFP1

Plant antimicrobial protein, MIAMP1

Streptomyces metalloproteinase inhibitor, SMPI [ PubMed 9735297].

Note: SMPI belongs to MEROPS inhibitor I36, clan IU. It inhibits members of the thermolysin family, MEROPS peptidase family M4, [ PubMed 14705960].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a gamma-Crystallin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the gamma-Crystallin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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gamma-Crystallin-like superfamily